DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14630 and CG5321

DIOPT Version :9

Sequence 1:	NP_651985.1	Gene:	CG14630 / 44620	FlyBaseID:	FBgn0014903	Length:	406	Species:	Drosophila melanogaster
Sequence 2:	NP_001285244.1	Gene:	CG5321 / 32399	FlyBaseID:	FBgn0030575	Length:	413	Species:	Drosophila melanogaster

Alignment Length:	373	Identity:	184/373 - (49%)
Similarity:	267/373 - (71%)	Gaps:	5/373 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 VEVQEEQGNL-LKYPQVWLRDNCQCAECFHAATRARKSHWDRGPLNI-PVSQVAYNKERKQLEII 92
            :|||.|..:. |.:|.:||||||.|.:|||.::::||..||.....| ||| :..:::.|::.:.
  Fly    36 IEVQPEANSKPLTFPGIWLRDNCMCEDCFHGSSKSRKLDWDNFDTRIRPVS-LQTDEQSKEVLVK 99

  Fly    93 WQDKHRSTFDLGWLRERDFGETGRKHYLEEVYKPPAQLWGKTEFEDVKREFQYEDVLEQDAALRV 157
            |.|.|.|.|.|.||:||.|....::.||.:.|:|..:.|...||:|:.:.|.|::|:.||:.|..
  Fly   100 WSDAHESRFSLKWLKERCFEPDKQQEYLRDFYRPTTRHWSGAEFQDIAQHFSYDEVMSQDSVLMQ 164

  Fly   158 WLEALAVQGFAILKGAPNDINVAKKLAERIGYIKRTTYGDVFEVKSKPNARNYAYLMTPLPLHTD 222
            ||:|||:.|.|:|:|||.|..|.::||:|:|:|:|||||:.|.|::||.|:|:|||...||||||
  Fly   165 WLQALAIYGVALLRGAPLDEGVVRRLADRVGFIRRTTYGEEFVVQAKPGAQNFAYLSLTLPLHTD 229

  Fly   223 MPYYEYKAGINILHTLVQSESKGGANTLTDGFNVASQLQKLHPEDFEVLKSVPVNWFDIGHDGDD 287
            :||||||..:||||.:||::|.||:|.|.|||:||..|::.||||||.|..:.|:|.|||  .:|
  Fly   230 LPYYEYKPSVNILHCVVQTDSPGGSNMLVDGFHVADLLRRDHPEDFERLSRIVVDWNDIG--SED 292

  Fly   288 SKPFHSLWRAPVICLDVDGRFARINQNTTKRDSRFSVSLAQAVSWYKAYDKFLEIAQSEAVEFKT 352
            .:.||::|||||||||.:||:.|||.:..:|||.|:|.|.:.:.||::|..|:.:|.:::..|||
  Fly   293 GREFHNIWRAPVICLDEEGRYTRINHSVPQRDSHFNVPLEEVLPWYESYALFVRLAIADSHAFKT 357

  Fly   353 QAGDVFVFNNLRMLHGRTAYEDAPGNKRHLVGAYVDWDIIYSKLRTLK 400
            :.|||..|||:|:|||||.|:|:..:.|::||||:|||||||:||.||
  Fly   358 RPGDVLTFNNIRLLHGRTGYDDSEESPRYIVGAYLDWDIIYSRLRVLK 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14630	NP_651985.1	carnitine_bodg	30..400	CDD:274118	182/371 (49%)
		DUF971	<41..107	CDD:294847	27/66 (41%)
		CAS_like	120..390	CDD:238154	137/269 (51%)
CG5321	NP_001285244.1	DUF971	<48..113	CDD:294847	26/65 (40%)
		carnitine_bodg	49..405	CDD:274118	177/358 (49%)
		CAS_like	127..395	CDD:238154	137/269 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457819
Domainoid	1	1.000	195	1.000	Domainoid score	I3098
eggNOG	1	0.900	-	-		E1_COG2175
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	265	1.000	Inparanoid score	I3037
Isobase	1	0.950	-	0.909372	Normalized mean entropy	S3503
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D49489at7147
OrthoFinder	1	1.000	-	-		FOG0003526
OrthoInspector	1	1.000	-	-		otm26624
orthoMCL	1	0.900	-	-		OOG6_102379
Panther	1	1.100	-	-	P	PTHR10696
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2023
SonicParanoid	1	1.000	-	-		X2892
	13	12.780