DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14630 and gbh-1

DIOPT Version :9

Sequence 1:	NP_651985.1	Gene:	CG14630 / 44620	FlyBaseID:	FBgn0014903	Length:	406	Species:	Drosophila melanogaster
Sequence 2:	NP_496305.1	Gene:	gbh-1 / 174648	WormBaseID:	WBGene00001522	Length:	421	Species:	Caenorhabditis elegans

Alignment Length:	418	Identity:	128/418 - (30%)
Similarity:	204/418 - (48%)	Gaps:	33/418 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LISRLSL--LRQASTFACV------RLCPDYVEVQEEQGNLLKYPQVWLRDNCQCAECF--HAAT 61
            ::|.|.:  :|.||..|.|      |:    |.|:...|....:|.:||||.......:  ..|.
Worm     1 MLSALLIRNIRNASKLASVAGPNSDRI----VNVKWSDGKTGVFPLIWLRDTSPDPSTYTISPAM 61

  Fly    62 RARKSHWDRGPLNIPVSQVA----YNKERKQLEIIWQDKHRSTFDLGWLRERDFGETGRKHYLEE 122
            .|||...    |...|.|.|    .:::...|:|.|:....|.|...||:.|:..:...:....:
Worm    62 TARKLTM----LEFDVEQNARKLWIDEDANCLKIEWESGVLSEFPSEWLKIRNPSDQEARRRRRK 122

  Fly   123 VYKPPAQLWGKTEFEDVKREFQYEDVLEQDAALRVWLEALAVQGFAILKGAPNDINVA-KKLAER 186
            ||..|.|.|||.|.|...::|.:|:.::.:..:..:|:|:.:.|.|:|||||..:..| :.:.:|
Worm   123 VYLFPEQTWGKAEIEGKLKKFSHEEFMKNEQVVHDFLQAVCIDGIAVLKGAPQGVRGAVEAIGDR 187

  Fly   187 IGYIKRTTYGDVFEVKSKPNARNYAYLMT-PLPLHTDMPYYEYKAGINILHTLVQSESKGGANTL 250
            ||.||||.:|.||||..|.:|.|.||... .||.|||.|...:...:.:|| ::||..:||.:..
Worm   188 IGMIKRTHFGLVFEVSLKADASNMAYASNGGLPFHTDFPSLSHPPQLQMLH-MLQSAEEGGHSLF 251

  Fly   251 TDGFNVASQLQKLHPEDFEVLKSVPVNWFDIGHDGDDSK------PFHSLWRAPVICLDVDGRFA 309
            .|||:||.||:...||.|::|.:..:.:.:.|:|..:..      .:....|..||.|:.||:..
Worm   252 VDGFHVAEQLRVEKPEIFKILTTQSMEYIEEGYDVHEINGKTIRFDYDMCARHKVIRLNDDGKVN 316

  Fly   310 RINQNTTKRDSRFSVSLAQAVSWYKAYDKFLEIAQS--EAVEFKTQAGDVFVFNNLRMLHGRTAY 372
            :|......|...:....::....|:|...|.|....  ..::|:.:.||..::.|.|:||.|..:
Worm   317 KIQFGNAMRSWFYDCEPSKVQDVYRAMKTFTEYCYQPRNMLKFRLEDGDTVLWANQRLLHTRDGF 381

  Fly   373 EDAPGNKRHLVGAYVDWDIIYSKLRTLK 400
            .:||...|.|.|.|.||||:.|::|.|:
Worm   382 RNAPEKARTLTGCYFDWDIVKSRVRFLR 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14630	NP_651985.1	carnitine_bodg	30..400	CDD:274118	119/385 (31%)
		DUF971	<41..107	CDD:294847	19/71 (27%)
		CAS_like	120..390	CDD:238154	90/279 (32%)
gbh-1	NP_496305.1	DUF971	25..>50	CDD:294847	9/28 (32%)
		carnitine_bodg	27..410	CDD:274118	120/392 (31%)
		CAS_like	125..399	CDD:238154	88/274 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162647
Domainoid	1	1.000	124	1.000	Domainoid score	I3408
eggNOG	1	0.900	-	-		E1_COG2175
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	186	1.000	Inparanoid score	I2601
Isobase	1	0.950	-	0.909372	Normalized mean entropy	S3503
OMA	1	1.010	-	-		QHG52475
OrthoDB	1	1.010	-	-		D534559at33208
OrthoFinder	1	1.000	-	-		FOG0003526
OrthoInspector	1	1.000	-	-		otm14604
orthoMCL	1	0.900	-	-		OOG6_102379
Panther	1	1.100	-	-	O	PTHR10696
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2023
SonicParanoid	1	1.000	-	-		X2892
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.750