Protein Alignment MAPk-Ak2 and MAPKAPK5

DIOPT Version :9

• Sequence 1: NP_001188547.1
• Gene: MAPk-Ak2 / 44573
• FlyBaseID: FBgn0013987
• Length: 359
• Species: Drosophila melanogaster
• Sequence 2: NP_001358408.1
• Gene: MAPKAPK5 / 8550
• HGNCID: 6889
• Length: 479
• Species: Homo sapiens
• Alignment Length: 363
• Identity: 144/363 - (39%)
• Similarity: 210/363 - (57%)
• Gaps: 40/363 - (11%)

  Fly    11 KTTPLTDDY-VTSNTVLGYGINGKVVQCTHRRTQQNYALKVLLDSERARREVDLHWRVSGCRYIV 74
            |.|.:.::| :.....||.||:|.|..|..:.||:.:|||:|||..:||.||.||...:....||
Human    12 KETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKARNEVRLHMMCATHPNIV 76

  Fly    75 NIIDVYENTFK------DRKCLLVVMECMEGGELFQRIQDKADGAFTEREAAQIMHEICAAVDYL 133
            .||:|:.|:.:      .|..||:|||.|||||||.||.....  |||::|:|:..:|..|:.:.
Human    77 QIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRH--FTEKQASQVTKQIALALRHC 139

  Fly   134 HSRDIAHRDLKPENLLYTTTQPNATLKLTDFGFAKETFTSYTLQTPCYTPYYVAPEVL------- 191
            |..:||||||||||||:.....:|.:||.||||||  .....|.||.:|||||||:||
Human   140 HLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAK--IDQGDLMTPQFTPYYVAPQVLEAQRRHQ 202

  Fly   192 -----------GPEKYDKSCDIWSLGVVMYIIMCGFPPFYS-NHGLAISPGMKNRIRTGQYDFPD 244
                       .|..|:||||:|||||::|:::||:||||| :|...|...|:.:|.||.::||:
Human   203 KEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRRKIMTGSFEFPE 267

  Fly   245 PEWTNVSQAAKDLIKGMLNVDPSKRLRIQDVISNKWI----AQYNAVPQTPLCTGRMLKEAEETW 305
            .||:.:|:.|||:::.:|.|.|.:||.|:.|:.:.|:    |..|.:|...|...:.:...
Human   268 EEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEALDNVLPSAQLMMDKAVVAG---- 328

  Fly   306 PEVQEEMTRSLATMRVDYDQMQIKALDKSNNPLLTKRR 343
              :|:.....||.||:...::.:|.|...|||:|.||:
Human   329 --IQQAHAEQLANMRIQDLKVSLKPLHSVNNPILRKRK 364

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAPk-Ak2	NP_001188547.1	STKc_MAPKAPK	18..280	CDD:270991	124/287 (43%)
		S_TKc	25..281	CDD:214567	123/280 (44%)
MAPKAPK5	NP_001358408.1	STKc_MAPKAPK5	15..304	CDD:271073	124/292 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144791
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0604
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D363028at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24349
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850