Protein Alignment MAPk-Ak2 and PSKH2

DIOPT Version :10

• Sequence 1: NP_524769.1
• Gene: MAPk-Ak2 / 44573
• FlyBaseID: FBgn0013987
• Length: 359
• Species: Drosophila melanogaster
• Sequence 2: XP_016869418.1
• Gene: PSKH2 / 85481
• HGNCID: 18997
• Length: 504
• Species: Homo sapiens
• Alignment Length: 340
• Identity: 104/340 - (30%)
• Similarity: 174/340 - (51%)
• Gaps: 39/340 - (11%)

  Fly    25 VLGYGINGKVVQCTHRRTQQNYALKVLLDSERARR-----EVDLHWRVSGCRYIVNIIDVYENTF 84
            ::|.|...:||:...:.|::.:|:||:...||..|     |:.:..|||. ||||.:::::|.
Human   187 LIGTGSFSRVVRVEQKTTKKPFAIKVMETREREGREACVSELSVLRRVSH-RYIVQLMEIFET-- 248

  Fly    85 KDRKCLLVVMECMEGGELFQRIQDKADGAFTEREAAQIMHEICAAVDYLHSRDIAHRDLKPENLL 149
            :|:  :.:|||...|||||.|:  .|.|:||||:|.:|:..:...:.|||:..|.||:|||||||
Human   249 EDQ--VYMVMELATGGELFDRL--IAQGSFTERDAVRILQMVADGIRYLHALQITHRNLKPENLL 309

  Fly   150 YTTTQPNATLKLTDFGFAKETFTS--YTLQTPCYTPYYVAPEVLGPEKYDKSCDIWSLGVVMYII 212
            |......:.:.:||||.|.....|  :|::|.|.||.|:|||||..:.|..:.|:|:|||:.|.:
Human   310 YYHPGEESKILITDFGLAYSGKKSGDWTMKTLCGTPEYIAPEVLLRKPYTSAVDMWALGVITYAL 374

  Fly   213 MCGFPPFYSNHGLAISPGMKNRIRTGQYDFPDPEWTNVSQAAKDLIKGMLNVDPSKRLRIQDVIS 277
            :.||.||....    ...:..:|..|:|::....|.::|..|||.|..:|.::...|:.....:.
Human   375 LSGFLPFDDES----QTRLYRKILKGKYNYTGEPWPSISHLAKDFIDKLLILEAGHRMSAGQALD 435

  Fly   278 NKWIAQYNAVPQTPLCTGRMLKEAEETWPEVQEEMTRSLATMRVDYDQMQIKALDKSNN------ 336
            :.|:        ..:..|..:|       .:|..::|:|......:.|....|....::
Human   436 HPWV--------ITMAAGSSMK-------NLQRAISRNLMQRASPHSQSPGSAQSSKSHYSHKSR 485

  Fly   337 PLLTKRRKKIEEMEL 351
            .:.:||..:|.|..|
Human   486 HMWSKRNLRIVESPL 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAPk-Ak2	NP_524769.1	STKc_MAPKAPK	18..280	CDD:270991	91/261 (35%)
PSKH2	XP_016869418.1	Protein Kinases, catalytic domain	181..439	CDD:473864	91/262 (35%)