Protein Alignment MAPk-Ak2 and CAMK2D

DIOPT Version :10

• Sequence 1: NP_524769.1
• Gene: MAPk-Ak2 / 44573
• FlyBaseID: FBgn0013987
• Length: 359
• Species: Drosophila melanogaster
• Sequence 2: NP_001308498.1
• Gene: CAMK2D / 817
• HGNCID: 1462
• Length: 533
• Species: Homo sapiens
• Alignment Length: 369
• Identity: 116/369 - (31%)
• Similarity: 175/369 - (47%)
• Gaps: 68/369 - (18%)

  Fly    13 TPLTDDYVTSNTVLGYGINGKVVQCTHRRTQQNYALKVL-------LDSERARREVDLHWRVSGC 70
            |..||:|..... ||.|....|.:|....|.|.||.|::       .|.::..||..:      |
Human     8 TRFTDEYQLFEE-LGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARI------C 65

  Fly    71 RYI--VNIIDVYENTFKDRKCLLVVMECMEGGELFQRIQDKADGAFTEREAAQIMHEICAAVDYL 133
            |.:  .||:.::: :..:.....:|.:.:.|||||:.|  .|...::|.:|:..:.:|..:|::.
Human    66 RLLKHPNIVRLHD-SISEEGFHYLVFDLVTGGELFEDI--VAREYYSEADASHCIQQILESVNHC 127

  Fly   134 HSRDIAHRDLKPENLLYTTTQPNATLKLTDFGFAKET---------FTSYTLQTPCYTPYYVAPE 189
            |...|.||||||||||..:....|.:||.|||.|.|.         |..        ||.|::||
Human   128 HLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAG--------TPGYLSPE 184

  Fly   190 VLGPEKYDKSCDIWSLGVVMYIIMCGFPPFY--SNHGLAISPGMKNRIRTGQYDFPDPEWTNVSQ 252
            ||..:.|.|..|:|:.||::||::.|:|||:  ..|.|      ..:|:.|.||||.|||..|:.
Human   185 VLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRL------YQQIKAGAYDFPSPEWDTVTP 243

  Fly   253 AAKDLIKGMLNVDPSKRLRIQDVISNKWIAQYNAV------PQTPLC-----TGRMLKEAEETWP 306
            .|||||..||.::|:||:...:.:.:.||.|.:.|      .:|..|     ..|.||.|
Human   244 EAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGA----- 303

  Fly   307 EVQEEMTRSLATMRVDYDQMQIKALD--KSNNP--LLTKRRKKI 346
                .:|..|||......:..:|..|  |.||.  ::|..::.|
Human   304 ----ILTTMLATRNFSAAKSLLKKPDGVKINNKANVVTSPKENI 343

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAPk-Ak2	NP_524769.1	STKc_MAPKAPK	18..280	CDD:270991	92/281 (33%)
CAMK2D	NP_001308498.1	STKc_CaMKII	12..303	CDD:270988	102/314 (32%)
		CaMKII_AD	380..507	CDD:285524