Protein Alignment MAPk-Ak2 and CAMK4

DIOPT Version :10

• Sequence 1: NP_524769.1
• Gene: MAPk-Ak2 / 44573
• FlyBaseID: FBgn0013987
• Length: 359
• Species: Drosophila melanogaster
• Sequence 2: NP_001735.1
• Gene: CAMK4 / 814
• HGNCID: 1464
• Length: 473
• Species: Homo sapiens
• Alignment Length: 288
• Identity: 111/288 - (38%)
• Similarity: 157/288 - (54%)
• Gaps: 26/288 - (9%)

  Fly    10 PKTTPLTDDYVT--SN-----------TVLGYGINGKVVQCTHRRTQQNYALKVL---LDSERAR 58
            |.|..|..||..  ||           :.||.|....|.:|..:.||:.||||||   :|.:..|
Human    23 PGTASLVPDYWIDGSNRDALSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVR 87

  Fly    59 REVDLHWRVSGCRYIVNIIDVYENTFKDRKCLLVVMECMEGGELFQRIQDKADGAFTEREAAQIM 123
            .|:.:..|:|... |:.:.:::|...:    :.:|:|.:.|||||.||.:|  |.::||:||..:
Human    88 TEIGVLLRLSHPN-IIKLKEIFETPTE----ISLVLELVTGGELFDRIVEK--GYYSERDAADAV 145

  Fly   124 HEICAAVDYLHSRDIAHRDLKPENLLYTTTQPNATLKLTDFGFAKETFTSYTLQTPCYTPYYVAP 188
            .:|..||.|||...|.|||||||||||.|..|:|.||:.|||.:|.......::|.|.||.|.||
Human   146 KQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAP 210

  Fly   189 EVLGPEKYDKSCDIWSLGVVMYIIMCGFPPFYSNHGLAISPGMKNRIRTGQYDFPDPEWTNVSQA 253
            |:|....|....|:||:|::.||::|||.|||...|   ...|..||...:|.|..|.|..||..
Human   211 EILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERG---DQFMFRRILNCEYYFISPWWDEVSLN 272

  Fly   254 AKDLIKGMLNVDPSKRLRIQDVISNKWI 281
            ||||::.::.:||.|||.....:.:.|:
Human   273 AKDLVRKLIVLDPKKRLTTFQALQHPWV 300

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAPk-Ak2	NP_524769.1	STKc_MAPKAPK	18..280	CDD:270991	107/277 (39%)
CAMK4	NP_001735.1	STKc_CaMKIV	42..335	CDD:270987	104/269 (39%)
		Autoinhibitory domain	305..321
		PP2A-binding	306..323
		Calmodulin-binding. /evidence=ECO:0000255	322..341
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	341..368
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	445..473