DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MAPk-Ak2 and MAPKAPK3

DIOPT Version :9

Sequence 1:NP_001188547.1 Gene:MAPk-Ak2 / 44573 FlyBaseID:FBgn0013987 Length:359 Species:Drosophila melanogaster
Sequence 2:NP_001230854.1 Gene:MAPKAPK3 / 7867 HGNCID:6888 Length:382 Species:Homo sapiens


Alignment Length:339 Identity:221/339 - (65%)
Similarity:270/339 - (79%) Gaps:1/339 - (0%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 QRQPKTTPLTDDYVTSNTVLGYGINGKVVQCTHRRTQQNYALKVLLDSERARREVDLHWRVSGCR 71
            :|:||...:||||..|..|||.|:||||::|.||||.|..|||:|.||.:||:|||.||:.||..
Human    31 RREPKKYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGP 95

  Fly    72 YIVNIIDVYENTFKDRKCLLVVMECMEGGELFQRIQDKADGAFTEREAAQIMHEICAAVDYLHSR 136
            :||.|:|||||....::|||::||||||||||.|||::.|.||||||||:||.:|..|:.:|||.
Human    96 HIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSH 160

  Fly   137 DIAHRDLKPENLLYTTTQPNATLKLTDFGFAKETFTSYTLQTPCYTPYYVAPEVLGPEKYDKSCD 201
            :|||||:||||||||:.:.:|.|||||||||||| |...||||||||||||||||||||||||||
Human   161 NIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKET-TQNALQTPCYTPYYVAPEVLGPEKYDKSCD 224

  Fly   202 IWSLGVVMYIIMCGFPPFYSNHGLAISPGMKNRIRTGQYDFPDPEWTNVSQAAKDLIKGMLNVDP 266
            :|||||:|||::|||||||||.|.|||||||.|||.|||.||:|||:.||:.||.||:.:|..||
Human   225 MWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDP 289

  Fly   267 SKRLRIQDVISNKWIAQYNAVPQTPLCTGRMLKEAEETWPEVQEEMTRSLATMRVDYDQMQIKAL 331
            ::||.|...:::.||.|...||||||.|.|:|:|.::.|.||:||||.:||||||||||::||.|
Human   290 TERLTITQFMNHPWINQSMVVPQTPLHTARVLQEDKDHWDEVKEEMTSALATMRVDYDQVKIKDL 354

  Fly   332 DKSNNPLLTKRRKK 345
            ..|||.||.|||||
Human   355 KTSNNRLLNKRRKK 368

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MAPk-Ak2NP_001188547.1 STKc_MAPKAPK 18..280 CDD:270991 173/261 (66%)
S_TKc 25..281 CDD:214567 170/255 (67%)
MAPKAPK3NP_001230854.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..34 1/2 (50%)
STKc_MAPKAPK3 39..304 CDD:271074 175/265 (66%)
Autoinhibitory helix. /evidence=ECO:0000250 307..343 20/35 (57%)
Nuclear export signal (NES). /evidence=ECO:0000250 335..344 6/8 (75%)
p38 MAPK-binding site. /evidence=ECO:0000250 345..369 17/24 (71%)
Bipartite nuclear localization signal 1. /evidence=ECO:0000250 350..353 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 357..382 10/12 (83%)
Bipartite nuclear localization signal 2. /evidence=ECO:0000250 364..368 3/3 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165144790
Domainoid 1 1.000 377 1.000 Domainoid score I863
eggNOG 1 0.900 - - E1_KOG0604
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H55836
Inparanoid 1 1.050 467 1.000 Inparanoid score I1545
Isobase 1 0.950 - 0 Normalized mean entropy S1138
OMA 1 1.010 - - QHG52456
OrthoDB 1 1.010 - - D363028at33208
OrthoFinder 1 1.000 - - FOG0002999
OrthoInspector 1 1.000 - - otm42269
orthoMCL 1 0.900 - - OOG6_105148
Panther 1 1.100 - - LDO PTHR24349
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4637
SonicParanoid 1 1.000 - - X1992
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1817.750

Return to query results.
Submit another query.