Protein Alignment MAPk-Ak2 and CAMK1G

DIOPT Version :10

• Sequence 1: NP_524769.1
• Gene: MAPk-Ak2 / 44573
• FlyBaseID: FBgn0013987
• Length: 359
• Species: Drosophila melanogaster
• Sequence 2: NP_065172.1
• Gene: CAMK1G / 57172
• HGNCID: 14585
• Length: 476
• Species: Homo sapiens
• Alignment Length: 312
• Identity: 107/312 - (34%)
• Similarity: 172/312 - (55%)
• Gaps: 31/312 - (9%)

  Fly    11 KTTPLTDDYVTSNTVLGYGINGKVVQCTHRRTQQNYALKVLLDSERARREVDLHWRVSGCR---- 71
            :||.:...::... |||.|...:|.....|.|.:.:|||.:..|. |.|:..|...::..:
Human    15 QTTNIRKTFIFME-VLGSGAFSEVFLVKQRLTGKLFALKCIKKSP-AFRDSSLENEIAVLKKIKH 77

  Fly    72 -YIVNIIDVYENTFKDRKCLLVVMECMEGGELFQRIQDKADGAFTEREAAQIMHEICAAVDYLHS 135
             .||.:.|:||:|..    ..:||:.:.|||||.||.::  |.:||::|:.::.::.:||.|||.
Human    78 ENIVTLEDIYESTTH----YYLVMQLVSGGELFDRILER--GVYTEKDASLVIQQVLSAVKYLHE 136

  Fly   136 RDIAHRDLKPENLLYTTTQPNATLKLTDFGFAKETFTSYTLQTPCYTPYYVAPEVLGPEKYDKSC 200
            ..|.|||||||||||.|.:.|:.:.:||||.:|.. .:..:.|.|.||.|||||||..:.|.|:.
Human   137 NGIVHRDLKPENLLYLTPEENSKIMITDFGLSKME-QNGIMSTACGTPGYVAPEVLAQKPYSKAV 200

  Fly   201 DIWSLGVVMYIIMCGFPPFYSNHGLAISPGMKNRIRTGQYDFPDPEWTNVSQAAKDLIKGMLNVD 265
            |.||:||:.||::||:||||..    ....:..:|:.|.|:|..|.|.::|::|||.|..:|..|
Human   201 DCWSIGVITYILLCGYPPFYEE----TESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKD 261

  Fly   266 PSKRLRIQDVISNKWIAQYNAVPQTPLCTGRMLKEAEETWPEVQEEMTRSLA 317
            |::|...:..:|:.||....|:.:             :.:|.|..::.::.|
Human   262 PNERYTCEKALSHPWIDGNTALHR-------------DIYPSVSLQIQKNFA 300

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAPk-Ak2	NP_524769.1	STKc_MAPKAPK	18..280	CDD:270991	99/266 (37%)
CAMK1G	NP_065172.1	STKc_CaMKI_gamma	19..303	CDD:271068	105/308 (34%)
		Autoinhibitory domain. /evidence=ECO:0000250	277..317		5/37 (14%)
		Calmodulin-binding. /evidence=ECO:0000250	297..318		1/4 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	325..352