Protein Alignment MAPk-Ak2 and CAMK1D

DIOPT Version :10

• Sequence 1: NP_524769.1
• Gene: MAPk-Ak2 / 44573
• FlyBaseID: FBgn0013987
• Length: 359
• Species: Drosophila melanogaster
• Sequence 2: NP_705718.1
• Gene: CAMK1D / 57118
• HGNCID: 19341
• Length: 385
• Species: Homo sapiens
• Alignment Length: 262
• Identity: 95/262 - (36%)
• Similarity: 148/262 - (56%)
• Gaps: 15/262 - (5%)

  Fly    26 LGYGINGKVVQCTHRRTQQNYALKVLLDSERARREVDLHWRVSGCRYI--VNII---DVYENTFK 85
            ||.|...:||....:.|.:.:|:|.:.......:|..:...::..|.|  .||:   |:||:.
Human    29 LGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESP-- 91

  Fly    86 DRKCLLVVMECMEGGELFQRIQDKADGAFTEREAAQIMHEICAAVDYLHSRDIAHRDLKPENLLY 150
              ..|.:||:.:.|||||.||.:|  |.:||::|:.::.::..||.|||...|.|||||||||||
Human    92 --NHLYLVMQLVSGGELFDRIVEK--GFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLY 152

  Fly   151 TTTQPNATLKLTDFGFAKETFTSYTLQTPCYTPYYVAPEVLGPEKYDKSCDIWSLGVVMYIIMCG 215
            .:....:.:.::|||.:|.......:.|.|.||.|||||||..:.|.|:.|.||:||:.||::||
Human   153 YSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCG 217

  Fly   216 FPPFYSNHGLAISPGMKNRIRTGQYDFPDPEWTNVSQAAKDLIKGMLNVDPSKRLRIQDVISNKW 280
            :||||..:    ...:..:|...:|:|..|.|.::|.:|||.|:.::..||:||...:....:.|
Human   218 YPPFYDEN----DSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPW 278

  Fly   281 IA 282
            ||
Human   279 IA 280

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAPk-Ak2	NP_524769.1	STKc_MAPKAPK	18..280	CDD:270991	92/258 (36%)
CAMK1D	NP_705718.1	STKc_CaMKI_delta	12..312	CDD:271070	95/262 (36%)
		Autoinhibitory domain. /evidence=ECO:0000250	279..319		2/2 (100%)
		Calmodulin-binding. /evidence=ECO:0000250	299..320
		Nuclear export signal. /evidence=ECO:0000250	318..324
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	360..385