Protein Alignment MAPk-Ak2 and Camk1

DIOPT Version :10

• Sequence 1: NP_524769.1
• Gene: MAPk-Ak2 / 44573
• FlyBaseID: FBgn0013987
• Length: 359
• Species: Drosophila melanogaster
• Sequence 2: NP_598687.1
• Gene: Camk1 / 52163
• MGIID: 1098535
• Length: 374
• Species: Mus musculus
• Alignment Length: 285
• Identity: 100/285 - (35%)
• Similarity: 159/285 - (55%)
• Gaps: 16/285 - (5%)

  Fly     3 SLQNQRQPKTTPLTDDYVTSNTVLGYGINGKVVQCTHRRTQQNYALKVLLDSERARREVDLHWRV 67
            :::..|..:...:.|.| ....|||.|...:|:....:|||:..|:|.:.......:|..:...:
Mouse     4 AVEGPRWKQAEDIRDIY-DFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKKALEGKEGSMENEI 67

  Fly    68 SGCRYI--VNII---DVYENTFKDRKCLLVVMECMEGGELFQRIQDKADGAFTEREAAQIMHEIC 127
            :....|  .||:   |:||:...    |.::|:.:.|||||.||.:|  |.:|||:|::::.::.
Mouse    68 AVLHKIKHPNIVALDDIYESGGH----LYLIMQLVSGGELFDRIVEK--GFYTERDASRLIFQVL 126

  Fly   128 AAVDYLHSRDIAHRDLKPENLLYTTTQPNATLKLTDFGFAKETFTSYTLQTPCYTPYYVAPEVLG 192
            .||.|||...|.|||||||||||.:...::.:.::|||.:|.......|.|.|.||.|||||||.
Mouse   127 DAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLA 191

  Fly   193 PEKYDKSCDIWSLGVVMYIIMCGFPPFYSNHGLAISPGMKNRIRTGQYDFPDPEWTNVSQAAKDL 257
            .:.|.|:.|.||:||:.||::||:||||..:...:.    .:|...:|:|..|.|.::|.:|||.
Mouse   192 QKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLF----EQILKAEYEFDSPYWDDISDSAKDF 252

  Fly   258 IKGMLNVDPSKRLRIQDVISNKWIA 282
            |:.::..||.||...:..:.:.|||
Mouse   253 IRHLMEKDPEKRFTCEQALQHPWIA 277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAPk-Ak2	NP_524769.1	STKc_MAPKAPK	18..280	CDD:270991	95/266 (36%)
Camk1	NP_598687.1	STKc_CaMKI_alpha	16..278	CDD:271069	99/273 (36%)
		Autoinhibitory domain. /evidence=ECO:0000250	276..316		2/2 (100%)
		Calmodulin-binding. /evidence=ECO:0000250	296..317
		Nuclear export signal. /evidence=ECO:0000250	315..321