DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MAPk-Ak2 and mapkapk2a

DIOPT Version :9

Sequence 1:	NP_001188547.1	Gene:	MAPk-Ak2 / 44573	FlyBaseID:	FBgn0013987	Length:	359	Species:	Drosophila melanogaster
Sequence 2:	NP_958460.1	Gene:	mapkapk2a / 327321	ZFINID:	ZDB-GENE-030131-5532	Length:	382	Species:	Danio rerio

Alignment Length:	353	Identity:	219/353 - (62%)
Similarity:	278/353 - (78%)	Gaps:	12/353 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QNQRQP------------KTTPLTDDYVTSNTVLGYGINGKVVQCTHRRTQQNYALKVLLDSERA 57
            |.|:.|            |...:||||..:|.|||.||||:|::..::|:.:..|||:|.|..:|
Zfish    18 QQQQNPPQFMLGKGSLQIKKNAITDDYKITNQVLGLGINGRVLEIFYKRSGEKLALKMLHDCPKA 82

  Fly    58 RREVDLHWRVSGCRYIVNIIDVYENTFKDRKCLLVVMECMEGGELFQRIQDKADGAFTEREAAQI 122
            ||||:||||.|.|.:||.|:|||||.:::|||||:|||||:|||||.||||:.|.|||||||:.|
Zfish    83 RREVELHWRASSCTHIVKIVDVYENLYQNRKCLLIVMECMDGGELFSRIQDRGDQAFTEREASDI 147

  Fly   123 MHEICAAVDYLHSRDIAHRDLKPENLLYTTTQPNATLKLTDFGFAKETFTSYTLQTPCYTPYYVA 187
            |..|..|:.|||:.:|||||:||||||||:.:|||.||||||||||||.|..:|.||||||||||
Zfish   148 MKSIGEAIQYLHAINIAHRDVKPENLLYTSKRPNALLKLTDFGFAKETTTHNSLATPCYTPYYVA 212

  Fly   188 PEVLGPEKYDKSCDIWSLGVVMYIIMCGFPPFYSNHGLAISPGMKNRIRTGQYDFPDPEWTNVSQ 252
            ||||||||||||||:|||||:|||::||:||||||||||||||||.|||.|||:||:|||:.||:
Zfish   213 PEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKKRIRMGQYEFPNPEWSEVSE 277

  Fly   253 AAKDLIKGMLNVDPSKRLRIQDVISNKWIAQYNAVPQTPLCTGRMLKEAEETWPEVQEEMTRSLA 317
            .||.||:.:|..:|::|:.|.:.:::.||.|...||||||.|.|:|||.::||.:|:||||.:||
Zfish   278 EAKQLIRTLLKTEPTQRMTITEFMNHPWINQSMEVPQTPLHTSRVLKEEKDTWEDVKEEMTSALA 342

  Fly   318 TMRVDYDQMQIKALDKSNNPLLTKRRKK 345
            ||||||:|::||.::.|.||||.|||||
Zfish   343 TMRVDYEQIKIKRIEDSTNPLLIKRRKK 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAPk-Ak2	NP_001188547.1	STKc_MAPKAPK	18..280	CDD:270991	171/261 (66%)
MAPk-Ak2	NP_001188547.1	S_TKc	25..281	CDD:214567	168/255 (66%)
mapkapk2a	NP_958460.1	STKc_MAPKAPK2	42..344	CDD:271072	195/301 (65%)
mapkapk2a	NP_958460.1	S_TKc	49..306	CDD:214567	168/256 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	378	1.000	Domainoid score	I815
eggNOG	1	0.900	-	-		E1_KOG0604
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	468	1.000	Inparanoid score	I1493
OMA	1	1.010	-	-		QHG52456
OrthoDB	1	1.010	-	-		D363028at33208
OrthoFinder	1	1.000	-	-		FOG0002999
OrthoInspector	1	1.000	-	-		otm24356
orthoMCL	1	0.900	-	-		OOG6_105148
Panther	1	1.100	-	-	O	PTHR24349
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4637
SonicParanoid	1	1.000	-	-		X1992
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870