DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smyd3 and SET5

DIOPT Version :9

Sequence 1:	NP_524768.2	Gene:	Smyd3 / 44554	FlyBaseID:	FBgn0011566	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_012077.1	Gene:	SET5 / 856614	SGDID:	S000001250	Length:	526	Species:	Saccharomyces cerevisiae

Alignment Length:	414	Identity:	91/414 - (21%)
Similarity:	147/414 - (35%)	Gaps:	130/414 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 RGQRILTE-KPFA--------FVLKSQYRLERCDNCL---------------EATKVLKCS-NC- 75
            :||.||.| ||..        |::.:.....||...|               |..|.:.|| .|
Yeast   135 KGQIILKENKPIVYIPPLDKLFLISNGKACARCGKALYDLTQHKIMVHYLDCEVCKAIWCSEKCK 199

  Fly    76 ----------------------------RYVSYCHRSCQMQAW--------------GQHKHECP 98
                                        |:|:||.:.|...|:              |:.|.:..
Yeast   200 KAHASLHELLYHSWRSNRIDILHAGNWKRFVNYCEKYCFTAAFSVGLIYGSMLLDTTGEVKEQWQ 264

  Fly    99 FLKKVHPRVVPDAARMLCRLILRLEHG----GDLIRG--YYTE----HGSRKFRDLMSHYAEIKN 153
            .|..:..|.         |:.||...|    ..|:.|  .:||    :|::|..:        ||
Yeast   265 KLASISQRE---------RIKLRDASGIGSTFSLLNGTTVHTEEESDNGTKKGVE--------KN 312

  Fly   154 --DPMRLEHLDSLHAVLTDMMAESPSTVPNKTELMSIYGRLITNG-FNILDAEMNSIATAIYLGV 215
              |....|....|..          ...|..:|.:.....|...| |||     |.....:|..:
Yeast   313 IDDETVWEKCYELFC----------GAFPKASEEIDFEKFLTMIGTFNI-----NQYNGQVYHWI 362

  Fly   216 SITDHSCQPNAV--ATFEGNELHVHAIEDMECLDWSKIFISYIDLLNTPEQRRLDLKEHYYFLCV 278
            |..:|.|:|||.  ...|..||.:||.:.::  ...:|.|:|::.|:....||.:|:.::.|||.
Yeast   363 SFINHDCEPNAYIEQVEEHEELRLHARKPIK--KGEQIRITYVNPLHGVRLRRRELRVNWGFLCQ 425

  Fly   279 CSKCTDAKESKEMLAALCPN---RNCGAGISVDRNNCPRCDAGISPK----LRNAFNEAMTLTRH 336
            |.:|.:...:.|.:    ||   :|..|.:.|::.:........|.|    .:::..||....:.
Yeast   426 CDRCQNELSTFERV----PNLEKKNADANLGVEKIDSNDSSEDGSKKSTGNRKSSMREAQPDLKE 486

  Fly   337 NLENMKDVAYLDVCKVCLDKQTGV 360
            .|:|.|:.. ||:.:. :|.|..|
Yeast   487 ILKNGKEFE-LDIPET-VDTQGNV 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd3	NP_524768.2	zf-MYND	60..97	CDD:280009	15/95 (16%)
Smyd3	NP_524768.2	TPR_12	377..440	CDD:290160
SET5	NP_012077.1	SET	41..526	CDD:225491	91/414 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4564
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12197
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.860