DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smyd3 and ZMYND15

DIOPT Version :9

Sequence 1:	NP_524768.2	Gene:	Smyd3 / 44554	FlyBaseID:	FBgn0011566	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_001254751.1	Gene:	ZMYND15 / 84225	HGNCID:	20997	Length:	750	Species:	Homo sapiens

Alignment Length:	174	Identity:	36/174 - (20%)
Similarity:	52/174 - (29%)	Gaps:	78/174 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TVGSSRSATTSATASACSSKSKNLKNPAPQI-----KRGQRILTEKP-FAFVLKSQYRLERCDNC 63
            |||.:|             ..:.|::..|::     |...|....:| |.|   :..|...|..|
Human   268 TVGDAR-------------LHRELESLVPRLGVKLAKTPMRTWGPRPGFTF---ASLRARTCHVC 316

  Fly    64 ----LEATKVLKCSNCRYVSYCHRSCQMQAWGQ------HKHECPFLKKVHPRVVPDAARMLCRL 118
                .|| |:..|..|..|.||..:|....|.:      |:..||                  ||
Human   317 HRHSFEA-KLTPCPQCSAVLYCGEACLRADWQRCPDDVSHRFWCP------------------RL 362

  Fly   119 ILRLEHGGD---------------------------LIRGYYTE 135
            ...:|..|:                           |.|||:|:
Human   363 AAFMERAGELATLPFTYTAEVTSETFNKEAFLASRGLTRGYWTQ 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd3	NP_524768.2	zf-MYND	60..97	CDD:280009	13/46 (28%)
Smyd3	NP_524768.2	TPR_12	377..440	CDD:290160
ZMYND15	NP_001254751.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	109..199
		zf-MYND	313..359	CDD:280009	13/46 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	565..590
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	709..750
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148804
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.830