DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smyd3 and smyd5

DIOPT Version :9

Sequence 1:	NP_524768.2	Gene:	Smyd3 / 44554	FlyBaseID:	FBgn0011566	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_001004614.2	Gene:	smyd5 / 447875	ZFINID:	ZDB-GENE-040912-39	Length:	415	Species:	Danio rerio

Alignment Length:	393	Identity:	90/393 - (22%)
Similarity:	132/393 - (33%)	Gaps:	134/393 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SATASAC-------SSKSKNL--KNPAPQIKRGQRILTEKPFA---FVLKSQYRLERCDNCLEAT 67
            ||.||.|       :.|.|.|  |.|   .|:|..|..|:|..   |:..:.|:...|:.||.|.
Zfish    15 SAKASNCVDVRFINNVKGKGLFAKKP---FKKGDTIFIERPLVSSQFLWNALYKYRACEYCLRAL 76

  Fly    68 KVLK-----------------------------CSNCRYVSYCHRSCQMQAWGQ-HKHEC----- 97
            :..:                             |..|: |.||...|:..|..| ||..|
Zfish    77 ETAEENARRLSGLPALILPHPELCKVRPDRHQACPQCQ-VMYCSSECRQAAMDQYHKILCLGPSN 140

  Fly    98 -----PFLK------KVHPRVVPDAARMLCRLILRLEHGGDLIRGYYTEHGSRKFRDLMSHYAEI 151
                 |..|      .||......:..:|.:::..::...|      .|...|.|.:..|..|
Zfish   141 DDPDHPVNKLQDAWRSVHFPPETSSVMILAKMVATIKQTQD------KERWQRLFTNFCSRTA-- 197

  Fly   152 KNDPMRLEH----------LDSLHAVLTDMMAESP----STVPNKTELMSIYGRLITNGFNI--- 199
             |:...:.|          |..|..:.|..:.|..    .|......|.|:.|   |||..|
Zfish   198 -NEEEEIVHKLLGEKFQGQLGLLRNLFTTALYEDRLSQWFTPEGFRSLFSLVG---TNGQGIGTS 258

  Fly   200 --------------------------------LDAE----MNSIATAIYLGVSITDHSCQPNAVA 228
                                            :|.|    :|...:.::|..|..:|||.|||.|
Zfish   259 SLSQWVHACDALELPRQQREQLDAFIDQLYKDIDKETGDFLNCEGSGLFLLQSSCNHSCVPNAEA 323

  Fly   229 TFEGNE--LHVHAIEDMECLDWSKIFISYIDLL---NTPEQRRLDLKEHYYFLCVCSKCTDAKES 288
            :|..|.  ||:.|:.|:.  ...:|.|||:|..   .:...|...|:|:|.|:|.|.||....:.
Zfish   324 SFPENNFLLHLTALGDIG--PGEEICISYLDCCQRDRSRHSRHKILRENYLFICSCQKCLSQMDD 386

  Fly   289 KEM 291
            .:|
Zfish   387 ADM 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd3	NP_524768.2	zf-MYND	60..97	CDD:280009	14/66 (21%)
Smyd3	NP_524768.2	TPR_12	377..440	CDD:290160
smyd5	NP_001004614.2	zf-MYND	100..135	CDD:280009	10/35 (29%)
smyd5	NP_001004614.2	SET	<293..350	CDD:214614	19/58 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810