DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smyd3 and Smyd5

DIOPT Version :9

Sequence 1:	NP_524768.2	Gene:	Smyd3 / 44554	FlyBaseID:	FBgn0011566	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_650955.1	Gene:	Smyd5 / 42517	FlyBaseID:	FBgn0038869	Length:	393	Species:	Drosophila melanogaster

Alignment Length:	362	Identity:	76/362 - (20%)
Similarity:	126/362 - (34%)	Gaps:	126/362 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 ILTEKPFA---FVLKSQYRLERCDNCLEATKVL-------------------------------K 71
            |..|:||.   |.....|....||:|:...:.:                               :
  Fly    28 IFEEEPFVSRQFSWNVAYGYAACDHCMRPLETVLENVRRLASDPKVEVPLLQHDPTAQWVAQFTQ 92

  Fly    72 CSNCRYVSYCHRSCQMQAWGQ-HKHEC----------PF------LKKVHPRVVPDAARMLCRLI 119
            |..|: |.||...|.|:|..: |:..|          |.      .||:|  ..|:...::  ||
  Fly    93 CPRCK-VRYCSEDCLMEAQKRYHRVACMGAFHSDDTHPINVLNETWKKMH--YPPETGSIM--LI 152

  Fly   120 LRLEHGGDLIRGYYTEHGSRK--FRDLMSHYAEIKNDPMRLEH----------LDSLH------- 165
            :||       ...|.:...::  ...|.|..:.|.|...::.|          ::.|:
  Fly   153 VRL-------MALYQQSTKKEEFLEQLQSFQSLIVNREQKIYHKMLGENFEQQMEQLYLAFCNAF 210

  Fly   166 ------------------------------AVLTDMMA---ESPSTVPNKTELMSIYGRLITNGF 197
                                          :||:..:|   :.|.|...|.:|.::...|.....
  Fly   211 TGEEFSIFKTPDAFKTLMAILGTNSQGIATSVLSQWVAKVSDLPLTDSEKEQLDTVIDGLYAKVG 275

  Fly   198 NILDAEMNSIATAIYLGVSITDHSCQPNAVATFE-GNELHV-HAIEDMECLDWSKIFISYID--- 257
            ......:|:..:.:||..|..:|||.|||.:||. .|::.| .|:..::  ...:|.|||:|
  Fly   276 EFAGEFLNNEGSGLYLLQSKINHSCVPNACSTFPYSNDIVVLKALAPIQ--QGEEICISYLDECM 338

  Fly   258 LLNTPEQRRLDLKEHYYFLCVCSKC----TDAKESKE 290
            |..:...|...|:|:|.|:|.|.||    :|..|:.|
  Fly   339 LERSRHSRHKVLRENYVFICQCPKCRAQASDPDETSE 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd3	NP_524768.2	zf-MYND	60..97	CDD:280009	12/68 (18%)
Smyd3	NP_524768.2	TPR_12	377..440	CDD:290160
Smyd5	NP_650955.1	zf-MYND	87..118	CDD:280009	9/31 (29%)
Smyd5	NP_650955.1	SET	<296..333	CDD:279228	13/38 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452050
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740