DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smyd3 and Smyd5

DIOPT Version :9

Sequence 1:	NP_524768.2	Gene:	Smyd3 / 44554	FlyBaseID:	FBgn0011566	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_001101340.1	Gene:	Smyd5 / 312503	RGDID:	1309153	Length:	417	Species:	Rattus norvegicus

Alignment Length:	401	Identity:	97/401 - (24%)
Similarity:	151/401 - (37%)	Gaps:	136/401 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 GSSRSATTSATASACSSKSKNLKNPAPQ-IKRGQRILTEKPFA---FVLKSQYRLERCDNCLEAT 67
            |.:|.:......|  |:|.|.|.  |.| |::|:.|..|:|..   |:..:.||...||:||.|.
  Rat    17 GGARGSVEVRFVS--SAKGKGLF--ATQLIRKGETIFIERPLVASQFLWNALYRYRACDHCLRAL 77

  Fly    68 ---------------KVL--------------KCSNCRYVSYCHRSCQMQAWGQ-HKHECPFLKK 102
                           :||              .|..|: |:||...|::.|..| |:..||...:
  Rat    78 EKAEENAQRLTGKPGQVLPHPELCSVRKDLHQNCPRCQ-VTYCSAECRLAAAEQYHQILCPGPSQ 141

  Fly   103 VHPR--------------VVPDAA--RMLCRLILRLEHGGDLIRGYYTEHGSRKFRDLMSHY-AE 150
            ..||              ..|:.|  .::.|::..::...|      .:|..|    |.||: ::
  Rat   142 DDPRHPLNKLQEAWRSVHYPPETASIMLMARMVATVKQAKD------KDHWVR----LFSHFCSK 196

  Fly   151 IKNDPMRLEH----------LDSLHAVLTDMMAE---SPSTVPNKTELMSIYGRLITNGFNI--- 199
            ..|:...:.|          |:.|..:.|:.:.|   |....|:  ...|::..:.|||..|
  Rat   197 TANEEEEIVHKLLGDKFKGQLELLRRLFTEALYEETLSQWFTPD--GFRSLFALVGTNGQGIGTS 259

  Fly   200 ---------------------LDAEMNSI------ATAIYLGV---------SITDHSCQPNAVA 228
                                 ||..::.:      ||..:|..         |..:|||.|||..
  Rat   260 SLSQWVHACDALELKPQEREQLDTFIDQLYKDIEAATGEFLNCEGSGLFVLQSCCNHSCVPNAET 324

  Fly   229 TFEGNE--LHVHAIEDMECLDWSKIFISYIDLL---NTPEQRRLDLKEHYYFLCVCSKC------ 282
            :|..|.  |||.|:||:|  ...:|.|||:|..   .:...|...|:|:|.|:|.|.||
  Rat   325 SFPENNFLLHVTALEDIE--PGEEICISYLDCCQRERSRHSRHKILRENYLFVCSCPKCLAEADD 387

  Fly   283 ---TDAKESKE 290
               |..:|.:|
  Rat   388 PNVTSEEEEEE 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd3	NP_524768.2	zf-MYND	60..97	CDD:280009	16/66 (24%)
Smyd3	NP_524768.2	TPR_12	377..440	CDD:290160
Smyd5	NP_001101340.1	DUF4599	68..144	CDD:292015	18/76 (24%)
Smyd5	NP_001101340.1	SET	<298..351	CDD:214614	19/54 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810