DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smyd3 and Smyd1

DIOPT Version :9

Sequence 1:	NP_524768.2	Gene:	Smyd3 / 44554	FlyBaseID:	FBgn0011566	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_001100065.1	Gene:	Smyd1 / 297333	RGDID:	1305105	Length:	490	Species:	Rattus norvegicus

Alignment Length:	492	Identity:	119/492 - (24%)
Similarity:	207/492 - (42%)	Gaps:	76/492 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TVGSSRSATTSATASACSSKSKNLKNPAPQIKRGQRILTEKPFAFVLKSQYRLERCDNCLEATKV 69
            ||||..:.....:    ..|.:.|| ...:......|..|:.::.|:........|..|.:..:.
  Rat     2 TVGSMENVEVFTS----EGKGRGLK-ATKEFWAADVIFAERAYSAVVFDSLINFVCHTCFKRQER 61

  Fly    70 L-KCSNCRYVSYCHRSCQMQAWGQHKHECPFLKKVHPRVVPDAARMLCRLILRLEHGGDLIRGYY 133
            | :|..|::..||.|:||..||..||:||..:|: :.:|..:..|:..|::.|:|..|..:
  Rat    62 LHRCGQCKFAHYCDRTCQKDAWLNHKNECSAIKR-YGKVPNENIRLAARIMWRVEREGTGL---- 121

  Fly   134 TEHGSRKFRDL---MSHYAEIKNDPMRLEHLDSLHAVLTDMMAESPSTVPNKTELMS-IYGRLIT 194
            ||.......||   :.|:.|.:...:|::       |.|.:....|.:.....:.:| |:|.:..
  Rat   122 TEGCLVSVDDLQNHVEHFGEEEQKELRVD-------VDTFLQYWPPQSQQFSMQYISHIFGVINC 179

  Fly   195 NGFNILDAE-MNSIATAIYLGVSITDHSCQPNAVATF-EGNE------LHVHAIEDMECL----D 247
            |||.:.|.. :.::...|:..:.:.:|.|.||....| .||.      .|.....::..|    :
  Rat   180 NGFTLSDQRGLQAVGVGIFPNLGLVNHDCWPNCTVIFNNGNHEAVKSMFHTQMRIELRALGKISE 244

  Fly   248 WSKIFISYIDLLNTPEQRRLDLKEHYYFLCVCSKC-------------TDAKESKEMLAALCPNR 299
            ..::.:||||.|:..|:||..||:.|||.|.|..|             .|.|.|:|::..:
  Rat   245 GEELTVSYIDFLHLSEERRQQLKKQYYFDCSCEHCQKGLKDDLFLAVKEDPKPSQEVVKEM---- 305

  Fly   300 NCGAGISVDRNNCPRCDAGISPKLRNAFNEAMTLTRHNLENMKDVAYLDVCKVCLDKQTGVFHPL 364
                 ....::...:.|...|..|   ::|.:.|                |:.||:||..||...
  Rat   306 -----TQFSKDTLEKIDKARSEGL---YHEVVKL----------------CRECLEKQEPVFADT 346

  Fly   365 NVWYVKTLDAAFEAAIEVGKWSDALDYGQRLLPGFRKYHGPWNPLLGLLHMKLGKIQLYEGHSKE 429
            |::.::.|....|....:..:.:|..|.:|::.|:.|.:...|..||:..|:.|....:.||.:.
  Rat   347 NLYVLRLLSIVSEVLSYLQAFEEASHYARRMVDGYMKLYHHNNAQLGMAVMRAGLTNWHAGHIEV 411

  Fly   430 ALHHLEEAQRILTVTHGRDHRLLTEQLYMLVLQARQE 466
            ....:.:|..||.||||..|. :|:.|..:.:|...|
  Rat   412 GHGMICKAYAILLVTHGPSHP-ITKDLEAMRMQTEME 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd3	NP_524768.2	zf-MYND	60..97	CDD:280009	14/37 (38%)
Smyd3	NP_524768.2	TPR_12	377..440	CDD:290160	14/62 (23%)
Smyd1	NP_001100065.1	zf-MYND	52..90	CDD:280009	14/37 (38%)
Smyd1	NP_001100065.1	SET	<194..257	CDD:214614	14/62 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342721
Domainoid	1	1.000	73	1.000	Domainoid score	I9024
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	146	1.000	Inparanoid score	I4326
OMA	1	1.010	-	-		QHG55359
OrthoDB	1	1.010	-	-		D553549at33208
OrthoFinder	1	1.000	-	-		FOG0000637
OrthoInspector	1	1.000	-	-		otm45999
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12197
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X437
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.870