DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smyd3 and set6

DIOPT Version :9

Sequence 1:	NP_524768.2	Gene:	Smyd3 / 44554	FlyBaseID:	FBgn0011566	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_596514.1	Gene:	set6 / 2541370	PomBaseID:	SPBP8B7.07c	Length:	483	Species:	Schizosaccharomyces pombe

Alignment Length:	424	Identity:	90/424 - (21%)
Similarity:	156/424 - (36%)	Gaps:	123/424 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 GQRILTEKPFAFVLKSQYRLERCDNCL-EATKVLKCSNCRYVSYCHRSCQMQAWGQHKHECPFLK 101
            |:.|:.::.....|.|......|..|. |..|..:|:.|:.:.||.:.||...|..||.||..|:
pombe    27 GKIIIRKRVDILSLDSANLTRTCSTCTEEKVKTQRCAACKIIHYCSKGCQKADWPFHKLECKALQ 91

  Fly   102 KVHPR-VVPDAARMLCRLILRLEHGGDLI---RGYYTEHGSRKFRDLMSHYAEIKNDPMRLEHLD 162
            ..... ::|...|:|.||.|..:....:|   .|:..|     |:.:.|.:::.:.......|..
pombe    92 ASKQNGILPSVCRLLIRLYLLWQKNPAIIEPMEGHQNE-----FQAVSSSWSDAELIASAASHYT 151

  Fly   163 SLHAVLTDMMAESPSTVPNKTEL-MSIYGRLITNGFNILDAEMNSIATAIYLGVSITDHSCQPNA 226
            .::                :.|| ..::.||..|..|::.:..:|:...:...:...:|||.||.
pombe   152 QIY----------------QAELFQKLFCRLAVNAMNLVTSSFDSLGMCLDTILCRLNHSCDPNC 200

  Fly   227 VATFEGNELHVHAIEDMECLDWSKIFISYIDLLNTPEQRRLDLKEHYYFLCVCSKCTDAKESKEM 291
            ...|:|..:.:.:..|::  ...::||||||:......|:..|.:.|:|.|.|.:|.:...:||.
pombe   201 QIIFDGAIVQLVSKRDIK--KDEQLFISYIDIRLPKSIRQKQLLKKYFFSCYCPRCENDHTTKET 263

  Fly   292 LAALCPNRNCGAGISVDRNNCPRCDAGISPKLRNAFNEAMTLTRHNLENMKDVAYLDVCKVCLDK 356
            ..:....|                       |||    :.:|.: ||...:|:
pombe   264 DGSKWMGR-----------------------LRN----SKSLMK-NLAMARDL------------ 288

  Fly   357 QTGVFHPLNVWYVKTLDAAFEAAIEVGKWSDALDYGQRLLPGFRKYHGPWNPLLGLLHMKLGKIQ 421
                                        ||          .|:::...||:.||.  |:|||.:.
pombe   289 ----------------------------WS----------CGWKQTAFPWSNLLH--HIKLGMLD 313

  Fly   422 ----------LYEGHSK----EALHHLEEAQRIL 441
                      ||...|.    :|||.::|.|.:|
pombe   314 ESNFNGAFAALYLKSSADEFLDALHVVDEYQLLL 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd3	NP_524768.2	zf-MYND	60..97	CDD:280009	13/37 (35%)
Smyd3	NP_524768.2	TPR_12	377..440	CDD:290160	19/76 (25%)
set6	NP_596514.1	SET	5..483	CDD:225491	90/424 (21%)
		zf-MYND	49..87	CDD:280009	13/37 (35%)
		SET	<142..227	CDD:279228	18/102 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H41491
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000637
OrthoInspector	1	1.000	-	-		oto101775
orthoMCL	1	0.900	-	-		OOG6_101699
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2289
SonicParanoid	1	1.000	-	-		X437
TreeFam	1	0.960	-	-
	9	8.700