DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smyd3 and Smyd5

DIOPT Version :9

Sequence 1:	NP_524768.2	Gene:	Smyd3 / 44554	FlyBaseID:	FBgn0011566	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_659167.2	Gene:	Smyd5 / 232187	MGIID:	108048	Length:	416	Species:	Mus musculus

Alignment Length:	384	Identity:	89/384 - (23%)
Similarity:	140/384 - (36%)	Gaps:	131/384 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 SSKSKNLKNPAPQ-IKRGQRILTEKPFA---FVLKSQYRLERCDNCLEA---------------T 67
            |.|.|.|.  |.| |::|:.|..|:|..   |:..:.|:...||:||.|               :
Mouse    30 SIKGKGLF--ATQLIRKGETIFIERPLVAAQFLWNALYQYRACDHCLRALEKAEENAQRLTGKPS 92

  Fly    68 KVL--------------KCSNCRYVSYCHRSCQMQAWGQ-HKHECP---------------FLKK 102
            ::|              .|.:|: |.||...|::.|..| |:..||               ..:.
Mouse    93 QILPHPELCSVRKDLHQNCPHCQ-VMYCSAECRLAAAEQYHQILCPGPSHDPRHPLNKLQEAWRS 156

  Fly   103 VHPRVVPDAA--RMLCRLILRLEHGGDLIRGYYTEHGSRKFRDLMSHYAEIKNDPMRLEH----- 160
            ||  ..|:.|  .::.|::..::...|      .:|..|.|....|..|   |....:.|
Mouse   157 VH--YPPETASIMLMARMVATVKQAKD------KDHWVRLFNHFCSRTA---NQEQAIVHKLLKG 210

  Fly   161 -----LDSLHAVLTDMMAESPSTVPNKTE-LMSIYGRLITNGFNI-------------------- 199
                 |:.|..:..:.:.|...::....| ..|::..:.|||..|
Mouse   211 KFKDQLELLLGLFKEALYEEALSLWFTPEGFRSLFALVGTNGQGIGTSSLSQWVHACDALELTPQ 275

  Fly   200 ----LDAEMNSI------ATAIYLGV---------SITDHSCQPNAVATFEGNE--LHVHAIEDM 243
                ||..::.:      ||..:|..         |..:|||.|||..:|..|.  |||.|:||:
Mouse   276 DREQLDTFIDQLYKDIEAATGEFLNCEGSGLFVLQSCCNHSCVPNAETSFPENNFVLHVTALEDI 340

  Fly   244 ECLDWSKIFISYIDLL---NTPEQRRLDLKEHYYFLCVCSKC---------TDAKESKE 290
            :  ...:|.|||:|..   .:...|...|:|:|.|.|.|.||         |..:|.:|
Mouse   341 K--PGEEICISYLDCCQRERSRHSRHKILRENYLFNCSCPKCLAEADDPNVTSEEEEEE 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd3	NP_524768.2	zf-MYND	60..97	CDD:280009	15/66 (23%)
Smyd3	NP_524768.2	TPR_12	377..440	CDD:290160
Smyd5	NP_659167.2	SET	<297..350	CDD:214614	18/54 (33%)
Smyd5	NP_659167.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	383..416		3/15 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810