DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smyd3 and set-18

DIOPT Version :9

Sequence 1:	NP_524768.2	Gene:	Smyd3 / 44554	FlyBaseID:	FBgn0011566	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_871849.1	Gene:	set-18 / 172949	WormBaseID:	WBGene00044070	Length:	507	Species:	Caenorhabditis elegans

Alignment Length:	489	Identity:	128/489 - (26%)
Similarity:	194/489 - (39%)	Gaps:	110/489 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 KSKNL-KNPAPQIKRGQ------RI-LTEKPFAFVLKSQYRLERCDNCLE----ATKVLKCSNCR 76
            |:||: |...|.:::.:      || :.|.|||..:.:....|.|.|||.    ..|:|:|..|.
Worm     5 KNKNVPKQEDPLVQKDEISSIHARIKIFETPFATQVLNPKVSEFCANCLRGPAPGEKLLRCGGCN 69

  Fly    77 YVSYCHRSCQMQAWGQHKHECPFLKKVHPRVVPDAARMLCRLILR---LEHGGDLIRGYYTEHGS 138
            :..||.:.||..||..||.||..||...|.:.......|.::|.|   ||..||.: |...|
Worm    70 FSMYCSKECQATAWLVHKPECKRLKASFPNLPLTEVLFLSKVIDRIQFLEKNGDKL-GIEAE--- 130

  Fly   139 RKFRDLMSHYAEIKNDPMRLEHLDSLHAVLTDMMAESPSTVPNKTELMSIYGRLITNGFNILDAE 203
            |||..|:.|..:|::|..::.|.:.   :...|.|.....:..|.|...::.:...|..:|....
Worm   131 RKFSSLVDHKVDIRDDEEKMAHFEK---IFEKMGAFRGEEMIEKGEFFDVFCKATINSHSIHTNA 192

  Fly   204 MNSIATAIYLGVSITDHSCQPNAVATFEGNELHVH-AIEDMECLDWSKIFISYIDLLNTPEQRRL 267
            .|.:..|:.||||..:|||:|.....|:|..:.:. .:..::..:..:.||||||:..:...||.
Worm   193 GNEVGMALDLGVSKYNHSCRPTCSMVFDGYRVCLRPLVPGVDAENTEEAFISYIDVGRSKYIRRR 257

  Fly   268 DLKEHYYFLCVCSKCTDAKESKEMLAALCPNRNCGAGISVDRNNCPRCDAGISPKLRNAFNEAMT 332
            ||...:||.|.|::|.| .|...:.|..|.|              |.|||   |.|.:...|.|.
Worm   258 DLNSRWYFNCECTRCMD-PEDDALTAIRCAN--------------PACDA---PILTSETEEPMN 304

  Fly   333 LTRHNLENMKDVAYLDVCKVCLDKQTGVFHPLNVWYVKTLDAAFE----AAIEV--GKWSDALDY 391
            :.   .|..|.:...|..|...:            |:|||.|:|:    |.||.  ||..:.|..
Worm   305 IA---CEKCKTIVEEDTVKAAQE------------YMKTLPASFDPKCPAEIEALPGKLKELLAK 354

  Fly   392 GQRLLPGFRKYHGPWNPLLGLLHMKLGKI--------------QLYEGHS--------------- 427
            .:::|      | |.|..:..|...|..:              |:|..:.
Worm   355 AEQIL------H-PSNVYVARLRTALFHVTGTLTMDNLSSMHTQIYNNYKMCFPKADRHVGFQLL 412

  Fly   428 ------------KEALHHLEEAQRILTVTHGRDH 449
                        .||:.:..:|..|..|..|.||
Worm   413 HIVKALIEKDERDEAMPYAFDAMNIFEVCFGLDH 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd3	NP_524768.2	zf-MYND	60..97	CDD:280009	16/40 (40%)
Smyd3	NP_524768.2	TPR_12	377..440	CDD:290160	17/109 (16%)
set-18	NP_871849.1	zf-MYND	49..90	CDD:366792	16/40 (40%)
set-18	NP_871849.1	SET	82..274	CDD:394802	59/198 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	88	1.000	Domainoid score	I5046
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41491
Inparanoid	1	1.050	131	1.000	Inparanoid score	I3198
Isobase	1	0.950	-	0	Normalized mean entropy	S4564
OMA	1	1.010	-	-		QHG55359
OrthoDB	1	1.010	-	-		D553549at33208
OrthoFinder	1	1.000	-	-		FOG0000637
OrthoInspector	1	1.000	-	-		otm14060
orthoMCL	1	0.900	-	-		OOG6_101699
Panther	1	1.100	-	-	O	PTHR12197
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2289
SonicParanoid	1	1.000	-	-		X437
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.960