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Protein Alignment Smyd3 and SMYD1

DIOPT Version :9

Sequence 1:	NP_524768.2	Gene:	Smyd3 / 44554	FlyBaseID:	FBgn0011566	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_938015.1	Gene:	SMYD1 / 150572	HGNCID:	20986	Length:	490	Species:	Homo sapiens

Alignment Length:	456	Identity:	112/456 - (24%)
Similarity:	198/456 - (43%)	Gaps:	71/456 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 ILTEKPFAFVLKSQYRLERCDNCLE-ATKVLKCSNCRYVSYCHRSCQMQAWGQHKHECPFLKKVH 104
            |..|:.::.|:........|..|.: ..|:.:|..|::..||.|:||..||..||:||..:|: :
Human    33 IFAERAYSAVVFDSLVNFVCHTCFKRQEKLHRCGQCKFAHYCDRTCQKDAWLNHKNECSAIKR-Y 96

  Fly   105 PRVVPDAARMLCRLILRLEHGGDLIRGYYTEHGSRKFRDL---MSHYAEIKNDPMRLEHLDSLHA 166
            .:|..:..|:..|::.|:|..|..:    ||.......||   :.|:.|.:...:|::
Human    97 GKVPNENIRLAARIMWRVEREGTGL----TEGCLVSVDDLQNHVEHFGEEEQKDLRVD------- 150

  Fly   167 VLTDMMAESPSTVPNKTELMS-IYGRLITNGFNILDAE-MNSIATAIYLGVSITDHSCQPNAVAT 229
            |.|.:....|.:.....:.:| |:|.:..|||.:.|.. :.::...|:..:.:.:|.|.||....
Human   151 VDTFLQYWPPQSQQFSMQYISHIFGVINCNGFTLSDQRGLQAVGVGIFPNLGLVNHDCWPNCTVI 215

  Fly   230 F-EGNE------LHVHAIEDMECL----DWSKIFISYIDLLNTPEQRRLDLKEHYYFLCVCSKC- 282
            | .||.      .|.....::..|    :..::.:||||.||..|:|:..||:.|||.|.|..|
Human   216 FNNGNHEAVKSMFHTQMRIELRALGKISEGEELTVSYIDFLNVSEERKRQLKKQYYFDCTCEHCQ 280

  Fly   283 ------------TDAKESKEMLAALCPNRNCGAGISVDRNNCPRCDAGISPKLRNAFNEAMTLTR 335
                        .:.|.|:|::..:         |...::...:.|...|..|   ::|.:.|
Human   281 KKLKDDLFLGVKDNPKPSQEVVKEM---------IQFSKDTLEKIDKARSEGL---YHEVVKL-- 331

  Fly   336 HNLENMKDVAYLDVCKVCLDKQTGVFHPLNVWYVKTLDAAFEAAIEVGKWSDALDYGQRLLPGFR 400
                          |:.||:||..||...|::.::.|....|....:..:.:|..|.:|::.|:.
Human   332 --------------CRECLEKQEPVFADTNIYMLRMLSIVSEVLSYLQAFEEASFYARRMVDGYM 382

  Fly   401 KYHGPWNPLLGLLHMKLGKIQLYEGHSKEALHHLEEAQRILTVTHGRDHRLLTEQLYMLVLQARQ 465
            |.:.|.|..||:..|:.|....:.|:.:.....:.:|..||.||||..|. :|:.|..:.:|...
Human   383 KLYHPNNAQLGMAVMRAGLTNWHAGNIEVGHGMICKAYAILLVTHGPSHP-ITKDLEAMRVQTEM 446

  Fly   466 E 466
            |
Human   447 E 447

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.