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Protein Alignment Smyd3 and SMYD4

DIOPT Version :9

Sequence 1:	NP_524768.2	Gene:	Smyd3 / 44554	FlyBaseID:	FBgn0011566	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_443160.2	Gene:	SMYD4 / 114826	HGNCID:	21067	Length:	804	Species:	Homo sapiens

Alignment Length:	504	Identity:	108/504 - (21%)
Similarity:	177/504 - (35%)	Gaps:	140/504 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 CDNCLEAT-KVLKCSNCRYVSYCHRSCQMQAWG-QHKHECPF----------------------- 99
            |..||:.| ..:.|..|.|..||.:.|..|||. .|:.|||.
Human   296 CHRCLKHTLATVPCDGCSYAKYCSQECLQQAWELYHRTECPLGGLLLTLGVFCHIALRLTLLVGF 360

  Fly   100 --LKKVHPRV----------VPDAARMLCRLILRL---EHGGDL---------IRGYYTEHGSRK 140
              ::|:..::          :|::...:..|...|   |..|::         |.|.|..:.:..
Human   361 EDVRKIITKLCDKISNKDICLPESNNQVKTLNYGLGESEKNGNIVETPIPGCDINGKYENNYNAV 425

  Fly   141 FRDLMSHYAEIKNDPMRLEH----------------LDSLHAVLTDMMAES--------PSTVPN 181
            | :|:.|..  .:.|   ||                ..||.|:.|:.:..|        |...|:
Human   426 F-NLLPHTE--NHSP---EHKFLCALCVSALCRQLEAASLQAIPTERIVNSSQLKAAVTPELCPD 484

  Fly   182 KT-----------------ELMSIYGRLITNGFNILDAEMNSIATAIYLGVSITDHSCQPN---- 225
            .|                 :.|:........|..:.|:....:||.|:..:|:.:|||.||
Human   485 VTIWGVAMLRHMLQLQCNAQAMTTIQHTGPKGSIVTDSRQVRLATGIFPVISLLNHSCSPNTSVS 549

  Fly   226 ---AVATFEGNELHVHAIEDMECLDWSKIFISYIDLLNTPEQRRLDLKEHYYFLCVCSKCTDAKE 287
               .|||...::......|.:.|....|..:..       .:|:..|:..|:|.|.|..|  ..|
Human   550 FISTVATIRASQRIRKGQEILHCYGPHKSRMGV-------AERQQKLRSQYFFDCACPAC--QTE 605

  Fly   288 SKEMLA-----ALCPNRNCGAGISVDRNNCPRC------DAGIS--------PKLRNAFNEAMTL 333
            :..|.|     |.|.| :|||.:..|  :..||      ::.:|        ..|:.....|..|
Human   606 AHRMAAGPRWEAFCCN-SCGAPMQGD--DVLRCGSRSCAESAVSRDHLVSRLQDLQQQVRVAQKL 667

  Fly   334 TRHNLENMKDVAYLDVCKVCLDKQTGVFHPLNVWYVKTLDAAFEAAIEVGKWSDALDYGQRLLPG 398
            .|.. |..:.|..|..|:...:......|.:   ..:..|....|...:|.|..:..:.||.|..
Human   668 LRDG-ELERAVQRLSGCQRDAESFLWAEHAV---VGEIADGLARACAALGDWQKSATHLQRSLYV 728

  Fly   399 FRKYHGPWNPLLGLLHMKLGKIQLYEGHS-KEALHHLEEAQRILTVTHG 446
            ....|||.:..:|....||.:| .:.|.: .|||..:::|:.:|::..|
Human   729 VEVRHGPSSVEMGHELFKLAQI-FFNGFAVPEALSTIQKAEEVLSLHCG 776

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.