DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lola and CYK3

DIOPT Version :9

Sequence 1:	NP_788308.3	Gene:	lola / 44548	FlyBaseID:	FBgn0283521	Length:	970	Species:	Drosophila melanogaster
Sequence 2:	NP_010166.1	Gene:	CYK3 / 851440	SGDID:	S000002275	Length:	885	Species:	Saccharomyces cerevisiae

Alignment Length:	731	Identity:	132/731 - (18%)
Similarity:	237/731 - (32%)	Gaps:	276/731 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 RRRSMENDAHDN---SNSSVLQAAASN-------QSILQQTGAG------LAVSALVTTQLSSGP 231
            :|.|:|.|:..:   |||..|..:|.:       .|....|.||      .|.|...:.|.|..
Yeast   239 KRYSLEEDSISSGLFSNSQYLNDSACSSENSFALMSDFSATSAGSFARHKYAQSFSDSLQRSQN- 302

  Fly   232 AAGTSSQASSTQQ--QQPLTSTN----------VTKKTESAKLTSSTAAPAS-----------GA 273
            |.|.|::.:.:|:  ....:|.|          :..|..:...:||.::|.|           ..
Yeast   303 ANGCSTKINDSQEFGDSNASSRNGKMGDILRKIIIPKRNTNIYSSSVSSPKSPKAYPKLPDIQNL 367

  Fly   274 SASAAVQQA--------HLHQQQAQTTSD-------------------------AINTENVQAQS 305
            :.||...:|        ||::.:..|..|                         .:||..|:..:
Yeast   368 NLSATPDEARDWIAVKCHLNRARTLTKYDKHPRYMRALEENRDLILHPQDSIYNGLNTNEVKGNT 432

  Fly   306 QGGAQGVQGDDEDID------------EGSAVGGPNSATGPNPASASASAVHAGVVVK------- 351
            :.|...|:..:.:|:            :|       :.|..:.|..:.||.::.|:.|
Yeast   433 KPGLVDVELAELNIEYIDKMTWKRCIRDG-------TMTLDSWAQTTFSARYSTVLEKLRGIYIF 490

  Fly   352 --QLASVVDKSSSNHKHKIKDNSVSSVGSEMVIEPKAEYDDDAHDENVEDLTLDEEDMTMEELDQ 414
              ::.::.|           ||..|              |..|..:|:|.: |..:..|..||
Yeast   491 CTEMFALTD-----------DNGTS--------------DFSAEPQNLEKI-LYRKHCTPYEL-- 527

  Fly   415 TAGTSQGGEGSSQTYATWQHDRSQDELGLMAQ--DAQQRDPQASKQDKGEQTEGAQDEFELDDCL 477
                            ||...:..:.||:..:  ....:.|.|...           ||:.:.|.
Yeast   528 ----------------TWLFKKLANSLGITCEIVIGFLKTPSAINW-----------EFKYNHCW 565

  Fly   478 LESNDIVITQNKDGFVLHVKKLGNIT--AAKLEENQAVAQQQGQAAVTVTGPAGQPTPTITELLN 540
            |.     |..||:...:.| .|||:|  ..:...|:.:  ::.:.:..:..|        .|::
Yeast   566 LR-----ILVNKEWRFIDV-ILGNVTNPIHEFVNNRKI--KKAENSYFLMAP--------LEMI- 613

  Fly   541 AAAASHSEPK-------PTLTTLTS--TPIKLPS---SECELINIKKIIPATTTIATHHPHTSST 593
               .:|..|:       |::..|::  .|:..||   :|.:|....               |:.:
Yeast   614 ---YTHIPPREFEQHIVPSIDQLSALYLPLVFPSFFKNELKLYKFS---------------TALS 660

  Fly   594 IIHPHHIIQHVSQEPHHQEHHQQHQTIHIEEVPQTSQQHHQQQHHHQLQTVQPTHTQVQSIITAH 658
            .:....|.:...:.|:..|      ......:|..:::......:.:|...|....:.:|
Yeast   661 FLEDSEIYECSLEIPNDVE------VFASVVIPTDNEEASSAYRNMELALTQIKKQKAES----- 714

  Fly   659 PGQTINLV-----------------GLRNVQ--LADSKPIA---------SRIRYSRG-KIIGPT 694
             |:.|.|:                 |:|..|  :|:..|::         |.::|... ||...:
Yeast   715 -GRRIALIKAVLPPNVNKGSLYIHSGVRGTQTSIANIHPLSMMVPLTHKGSNMKYEFVIKIPSES 778

  Fly   695 VQNLQ--IVE------------THEPIQHQHHELSDGTKYEISEIDLNNPNASAAI------ISD 739
            :|.::  |||            :.|.||..    |||..|...|....|.....||      :.:
Yeast   779 IQKIELYIVEPQSRYLFVGNEYSFEVIQSP----SDGIVYSSDEGPNQNRKQPMAIKSPSGRVHE 839

  Fly   740 LVKYAEIDDIELPDGT 755
            |||    .|...|.||
Yeast   840 LVK----SDPHFPYGT 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lola	NP_788308.3	BTB	22..117	CDD:279045
		BTB	33..117	CDD:197585
		C2H2 Zn finger	905..925	CDD:275368
		C2H2 Zn finger	935..955	CDD:275368
CYK3	NP_010166.1	SH3	13..65	CDD:418401
CYK3	NP_010166.1	CYK3	28..882	CDD:227604	132/731 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S12536
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950