DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lola and BTBD18

DIOPT Version :9

Sequence 1:	NP_788308.3	Gene:	lola / 44548	FlyBaseID:	FBgn0283521	Length:	970	Species:	Drosophila melanogaster
Sequence 2:	NP_001138573.1	Gene:	BTBD18 / 643376	HGNCID:	37214	Length:	712	Species:	Homo sapiens

Alignment Length:	704	Identity:	135/704 - (19%)
Similarity:	241/704 - (34%)	Gaps:	168/704 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 ENETLVDCTLAAEGKFLKAHKVVLSACSPYFATLLQEQYDKHP------IFILKDVKYQELRAMM 85
            :::...|..|.|||:.:.||..:||||||:|...|:.:   .|      :..|..:|...||.::
Human    29 QSDVFCDVLLQAEGEAVPAHCCILSACSPFFTERLERE---RPAQGGKVVLELGGLKISTLRKLV 90

  Fly    86 DYMYRGEVNISQDQLAALLKAAESLQIKGLSDNRTGGG---VAP----------KPESS------ 131
            |::|..|:.:||::...:|.||..|::..|...:..||   .||          :|.|:
Human    91 DFLYTSEMEVSQEEAQDVLSAARQLRVSELESLQLEGGKLVKAPQGRRLNRECLQPTSAAPISAR 155

  Fly   132 ----GHHRGGKLS--------GAYTLEQTKRARLATGGAMDTSGDVSGS----REGSSSPSRRRR 180
                .||....|.        ||..|:...:...........:.::||:    |:..:.|:.:.:
Human   156 VVTPSHHPHTPLPTNQTPCPLGAIRLKSLGKEEGPQENNRQNADNLSGTLLLKRKARACPTPQEK 220

  Fly   181 KVRRRSMENDAHDNSNSSVLQAAASNQSIL-----------------QQTGAGLAVS--ALVTTQ 226
            .....|...:..:|.|.:.|.....:...|                 .:...|:..|  :.:.:.
Human   221 NSSPSSHSQEPRENKNDTALDPTVLSPPSLYPSVDKHLLPRKIRLSRSKPSPGICTSKPSSILSG 285

  Fly   227 LSSGPAA-------------GTSSQASSTQQQQPLTST----NVTKKTESAKLTSSTAAPASGAS 274
            .||.||.             .|........:..||.||    .:.|...|.|.:....||.|.::
Human   286 SSSVPATPGRRLWRQRSVNKETPEDKPKPGRASPLQSTPNPSGLGKTGGSRKRSPEVRAPNSDSA 350

  Fly   275 ASAAVQQAHLHQ-------QQAQTTSDAINTENVQAQSQGGAQGVQGDDEDIDEGSAVGGPNSAT 332
            ....|.:..|.:       :..|.|......::.|....||         |..|.|.. .|.|:.
Human   351 EEGQVGRVKLRKIVNGTCWEVVQETPLKNTQDSPQIPDPGG---------DFQEPSGT-QPFSSN 405

  Fly   333 GPNPASASASAVHAGVVVKQLASVVDKSSSNHKHKIKDNSVSSVGSEMVIEPKAEYDDDAHDENV 397
            ....:...........:..:|..::..:|.:..|.:..:...|  |..::|.:.....|..:...
Human   406 EQEMSPTRTELCQDSPMCTKLQDILVSASHSPDHPVVKSEFES--SPELVEKEPMLAIDCREPYA 468

  Fly   398 EDLTLDEEDMTMEE--LDQTAGTSQ------------------------GGEGS-------SQTY 429
            .|..|.|:....||  :...|.||:                        |.||.       ::|.
Human   469 FDTALLEQPCEAEEYRITSAAATSELEEILDFMLCGSDIEPPIGSLESPGAEGCRTPTYHLTETG 533

  Fly   430 ATW--QHDRSQDELGLMAQDAQQRDPQASKQDKG--EQTEGAQDEFELDDCLLESN----DIVIT 486
            ..|  ..:....::.|..::..:.:.:.:.:::|  |.........|:.:.|....    |:.||
Human   534 KNWIEGEEWCLPDMELWPRELTELEKEPAGENRGPTELLSPLVMPSEVSEVLSVGGRWTPDLEIT 598

  Fly   487 QNK--DG---FVLHVKKLGNITAAKLEENQAVAQ--QQGQAAVTVTGPAGQPTPTITELLNAAAA 544
            .::  ||   .:|||..|.....:..:.:...:.  :.|......|.....|:|.    .....:
Human   599 SSQPLDGQEDKLLHVSSLDTPQRSYGDLSPPCSNWVETGLEVSLTTDELLYPSPK----AGKEVS 659

  Fly   545 SHSEPKPTLTTLTSTPIKLPSSECELINI------KKIIPATTTIATHHPHTSS 592
            .|||      .|.|.|   .|||.|.|::      .:::|  ||:.:..|..||
Human   660 GHSE------LLGSLP---ASSEEEEIDVVDWTAEGRLVP--TTVPSVWPDPSS 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lola	NP_788308.3	BTB	22..117	CDD:279045	30/95 (32%)
		BTB	33..117	CDD:197585	30/89 (34%)
		C2H2 Zn finger	905..925	CDD:275368
		C2H2 Zn finger	935..955	CDD:275368
BTBD18	NP_001138573.1	BTB	24..120	CDD:306997	29/93 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..176		3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	212..355		23/142 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	374..410		9/45 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	653..676		9/35 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	691..712		5/12 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	63	1.000	Domainoid score	I10232
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.910