DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lola and mod(mdg4)

DIOPT Version :9

Sequence 1:	NP_788308.3	Gene:	lola / 44548	FlyBaseID:	FBgn0283521	Length:	970	Species:	Drosophila melanogaster
Sequence 2:	NP_788698.1	Gene:	mod(mdg4) / 49228	FlyBaseID:	FBgn0002781	Length:	610	Species:	Drosophila melanogaster

Alignment Length:	781	Identity:	187/781 - (23%)
Similarity:	295/781 - (37%)	Gaps:	226/781 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDDDQQFCLRWNNHQSTLISVFDTLLENETLVDCTLAAEGKFLKAHKVVLSACSPYFATLL-QEQ 64
            |.||:||.|.|||..:.|.:.|...|....|||.:|||||:.:|||::|||.|||:|..:. |..
  Fly     1 MADDEQFSLCWNNFNTNLSAGFHESLCRGDLVDVSLAAEGQIVKAHRLVLSVCSPFFRKMFTQMP 65

  Fly    65 YDKHPIFILKDVKYQELRAMMDYMYRGEVNISQDQLAALLKAAESLQIKGLSDNRTGGGVAPKP- 128
            .:.|.|..|.:|.:..|:.::.:||.||||:.||.|.|.:..|||||||||:||    ..||:|
  Fly    66 SNTHAIVFLNNVSHSALKDLIQFMYCGEVNVKQDALPAFISTAESLQIKGLTDN----DPAPQPP 126

  Fly   129 -ESS-----GHHRGGKLSGAYTLEQTKRARLATGGAMDTSGDVSGSREGSSSPSRRRRKVRRRSM 187
             |||     .|.:..::.......|..||  :....::|..|..|
  Fly   127 QESSPPPAAPHVQQQQIPAQRVQRQQPRA--SARYKIETVDDGLG-------------------- 169

  Fly   188 ENDAHDNSNSSVLQAAASNQ-SILQQTGAGLAVSALVTTQLSSGPAAGTSSQASSTQQQQPLTST 251
              |...::...|:|..|:.| :|:||.....|...:.:.||.:|...               |:|
  Fly   170 --DEKQSTTQIVIQTTAAPQATIVQQQQPQQAAQQIQSQQLQTGTTT---------------TAT 217

  Fly   252 NVTKKTESAKLTSSTAAPASGASASAAVQQAHLHQQQAQTTSDAINTENVQAQSQGGAQGVQGDD 316
            .|:....||:.:|.|.     ||:||.|:::        .||.:.|
  Fly   218 LVSTNKRSAQRSSLTP-----ASSSAGVKRS--------KTSTSAN------------------- 250

  Fly   317 EDIDEGSAVGGPNSATGPNPASASASAVHAGVVVKQLASVVDKSSSNHKHKIKDNSVSSVGSEMV 381
                    |..|..:|....|:.:|..|...:.|:  .|||..:.:    |:...|...|..|
  Fly   251 --------VMDPLDSTTETGATTTAQLVPQQITVQ--TSVVSAAEA----KLHQQSPQQVRQE-- 299

  Fly   382 IEPKAEYDDDAHDENVEDLTLDEEDMTMEELDQTAGTSQGGEGSSQTYATWQHDRSQDELGLMAQ 446
               :|||    .|..:|..|..|.|.: |:....||.::|......||...::|.|.
  Fly   300 ---EAEY----IDLPMELPTKSEPDYS-EDHGDAAGDAEGTYVEDDTYGDMRYDDSY-------- 348

  Fly   447 DAQQRDPQASKQDKGEQTEGAQDEFELDDCLLESNDIVITQNKDGFVLHVKKLGNITAAKLEENQ 511
                   ....:|.|.||                     ..|..|        |.:||.   .::
  Fly   349 -------FTENEDAGNQT---------------------AANTSG--------GGVTAT---TSK 374

  Fly   512 AVAQQQGQ-----AAVTVTGPAGQPTPTITELLNAAAAS--------HSEPKPTLTTLTSTPIKL 563
            ||.:||.|     :.|..:|..|.     ||...|.:||        ...||..:...|..|..|
  Fly   375 AVVKQQSQNYSESSFVDTSGDQGN-----TEAQAATSASATKIPPRKRGRPKTKVEDQTPKPKLL 434

  Fly   564 PSSECELINIKKIIPATTTIATHHPHTSST-----IIHPHHIIQHVSQEPH-------HQEHHQQ 616
            ...:...:|.:...||.        :.|:|     :|...|:.:...::..       ::||.::
  Fly   435 EKLQAATLNEEASEPAV--------YASTTKGGVKLIFNGHLFKFSFRKADYSVFQCCYREHGEE 491

  Fly   617 HQTIHIEEVPQTSQQHHQQQHHHQLQTVQPTHTQVQSIITAHPGQTINLVGLRNVQLADSKPIAS 681
            .:...:  ..|.....::.:|.|.:|....:....|.:    ||::    |:.: .|:.||
  Fly   492 CKVRVV--CDQKRVFPYEGEHVHFMQASDKSCLPSQFM----PGES----GVIS-SLSPSK---- 541

  Fly   682 RIRYSRGKIIGPTVQNLQIVETHEPIQHQHHELSDGTKYEISEIDLNNPNASAAIISDLVKYAEI 746
                   :::......|:..:..|....:..|:.     ||.||:|:.|..:.|      |..|:
  Fly   542 -------ELLMKNTTKLEEADDKEDEDFEEFEIQ-----EIDEIELDEPEKTPA------KEEEV 588

  Fly   747 D 747
            |
  Fly   589 D 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lola	NP_788308.3	BTB	22..117	CDD:279045	45/95 (47%)
		BTB	33..117	CDD:197585	41/84 (49%)
		C2H2 Zn finger	905..925	CDD:275368
		C2H2 Zn finger	935..955	CDD:275368
mod(mdg4)	NP_788698.1	BTB	22..118	CDD:279045	45/95 (47%)
		BTB	33..118	CDD:197585	41/84 (49%)
		FLYWCH	452..512	CDD:282369	8/61 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	63	1.000	Domainoid score	I10232
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	4.010