DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lola and ttk

DIOPT Version :9

Sequence 1:	NP_788308.3	Gene:	lola / 44548	FlyBaseID:	FBgn0283521	Length:	970	Species:	Drosophila melanogaster
Sequence 2:	NP_001189329.1	Gene:	ttk / 48317	FlyBaseID:	FBgn0003870	Length:	813	Species:	Drosophila melanogaster

Alignment Length:	939	Identity:	216/939 - (23%)
Similarity:	333/939 - (35%)	Gaps:	335/939 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QQFCLRWNNHQSTLISVFDTLLENETLVDCTLAAEGKFLKAHKVVLSACSPYFATLLQEQYDKHP 69
            |:||||||||||.|:||||.||..||..|.|||.||:.|||||:|||||||||.||.....:|||
  Fly     6 QRFCLRWNNHQSNLLSVFDQLLHAETFTDVTLAVEGQHLKAHKMVLSACSPYFNTLFVSHPEKHP 70

  Fly    70 IFILKDVKYQELRAMMDYMYRGEVNISQDQLAALLKAAESLQIKGLSD---------------NR 119
            |.|||||.|.::::::|:||||||::.|::|.|.|:.||||:||||::               ..
  Fly    71 IVILKDVPYSDMKSLLDFMYRGEVSVDQERLTAFLRVAESLRIKGLTEVNDDKPSPAAAAAGAGA 135

  Fly   120 TGG---GVAPK---------PESSGHHRGGKLSGAYTLEQTK--------------------RAR 152
            ||.   ...|:         |:.:....||.|:.|.....|.                    |.|
  Fly   136 TGSESTATTPQLQRIQPYLVPQRNRSQAGGLLASAANAGNTPTLPVQPSLLSSALMPKRKRGRPR 200

  Fly   153 LATGGAMDTSGD-------------------------VSGSREGS------------------SS 174
            ..:|.:..|..|                         .||:.:||                  |.
  Fly   201 KLSGSSNGTGNDYDDFDRENMMNDSSDLGNGKMCNESYSGNDDGSDDNQPNAGHTDDLNESRDSL 265

  Fly   175 PSRRRRKVRRRSMENDAHDNSNSSVLQAAASNQSILQQTGAGLAVSALVTTQLSSGPAAGTSSQA 239
            ||:|.:..:...:.:...||| :||....|:.:...:..|:            ||...:.|:...
  Fly   266 PSKRSKNSKDHRVVSHHEDNS-TSVTPTKATPELSQRLFGS------------SSTTISATAPGG 317

  Fly   240 SSTQQQQPLTSTNVTKKTESAKL-----------TSSTAAPA-SGASASAAVQQAHLHQQQAQTT 292
            |||...:.::...::.:.|||.:           ..:|..|| .|:..:....:..:.|......
  Fly   318 SSTGPSETISLLEISDERESAPVHLPTILGLKIRAINTTTPAQQGSPQTPTKSKPKIRQATGSNN 382

  Fly   293 SDAINTENVQAQSQGGAQGVQGDDEDIDEGSAVGG---PNSATGPNPASA-----------SASA 343
            |:::    ::.|.:|||:     |.::...:.:.|   ||:|......|.           :...
  Fly   383 SNSL----LKQQLRGGAK-----DPEVPPATRITGAVTPNAALNAEEQSKEMPKKNQDEVNACIG 438

  Fly   344 VH--AGVVVKQLASVVDKSSSNHK---HKIKDNSV---------------SSVGSEMVIEPKAEY 388
            :|  |....:|.|.|....:.:|:   |...:||:               ||.|..|
  Fly   439 LHSLANAAEQQAAQVASTGNLHHQLLLHMAANNSMLNTTDYYQQQQQESPSSAGQFM-------- 495

  Fly   389 DDDAHDENVEDLTL-------DEEDMTMEEL-DQTAGTSQGGEGSSQTYATWQHDRSQDELGLMA 445
                 |:::|.|:|       ||.|..|..| |:.||. .|.:|:.......|.|....|.....
  Fly   496 -----DDDLELLSLNDQQDKSDEPDHEMVTLADENAGL-PGYQGNEAEATPAQEDSPAAETATAP 554

  Fly   446 QDAQ----------------QRDPQASKQDKGEQ-----------------TEGAQDEFELDDCL 477
            ..|.                :|..|::..|:.|.                 .||.   :...:|.
  Fly   555 PPAPRSGKKGAKRPIQRRRVRRKAQSTLDDQAEHLTEMSVRGLDLFRYASVVEGV---YRCTECA 616

  Fly   478 LESNDIVITQNKDGFVLHVKKLGNITAAKLEENQAVAQQQGQAAVTVTGPAGQPTPTITELLNAA 542
            .|:..... :||..|..|                |....:|:
  Fly   617 KENMQKTF-KNKYSFQRH----------------AFLYHEGK----------------------- 641

  Fly   543 AASHSE--PKPTLTTLTSTPIKLPSSECELINIKKIIPATTTIATHHPHTSSTIIHPHHIIQHVS 605
               |.:  |.|..:...|.|.|:.:      ::|         .||...|....|.....::::.
  Fly   642 ---HRKVFPCPVCSKEFSRPDKMKN------HLK---------MTHENFTPPKDIGAFSPLKYLI 688

  Fly   606 QEPHHQEHHQQHQTIHIEEVPQTSQQHHQQQHHHQLQTVQPTHTQVQSIITAHPGQTINLVGLRN 670
            ......:   .|.||           :.|||.|:..|..:....|..|.
  Fly   689 SAAAAGD---MHATI-----------YQQQQDHYHRQLAEQLEQQNASF---------------- 723

  Fly   671 VQLADSKPIASRIRYSRGKIIGPTVQNLQIVETHEPIQHQHHELSDGTKYEISEIDLNNPNASAA 735
                ||:.         ..:|.|.|: ::..|..:  ..|..|||||      ..|.:||.|:||
  Fly   724 ----DSRD---------SSLILPDVK-MEHAEDQD--AEQEAELSDG------GYDASNPAAAAA 766

  Fly   736 IISDLVKYAEIDDIELPDGTKIGIGFAPS 764
            .:..|.:     |:.:.|  :|.|..:||
  Fly   767 AMLSLQQ-----DVIIKD--EIQISPSPS 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lola	NP_788308.3	BTB	22..117	CDD:279045	57/94 (61%)
		BTB	33..117	CDD:197585	51/83 (61%)
		C2H2 Zn finger	905..925	CDD:275368
		C2H2 Zn finger	935..955	CDD:275368
ttk	NP_001189329.1	BTB	23..119	CDD:279045	57/95 (60%)
		BTB	34..119	CDD:197585	51/84 (61%)
		C2H2 Zn finger	612..638	CDD:275370	7/42 (17%)
		zf-C2H2_4	646..669	CDD:290605	6/37 (16%)
		C2H2 Zn finger	648..669	CDD:275370	5/35 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	63	1.000	Domainoid score	I10232
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.010