DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lola and bab2

DIOPT Version :9

Sequence 1:	NP_788308.3	Gene:	lola / 44548	FlyBaseID:	FBgn0283521	Length:	970	Species:	Drosophila melanogaster
Sequence 2:	NP_523879.2	Gene:	bab2 / 44254	FlyBaseID:	FBgn0025525	Length:	1067	Species:	Drosophila melanogaster

Alignment Length:	885	Identity:	207/885 - (23%)
Similarity:	327/885 - (36%)	Gaps:	291/885 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DDQQFCLRWNNHQSTLISVFDTLLENETLVDCTLAAEGKFLKAHKVVLSACSPYFATLLQEQYDK 67
            :.|||||||||:||.|.:|||.||::|:.||.||:.||..:||||:|||||||||..|..:...:
  Fly   194 EGQQFCLRWNNYQSNLTNVFDELLQSESFVDVTLSCEGHSIKAHKMVLSACSPYFQALFYDNPCQ 258

  Fly    68 HPIFILKDVKYQELRAMMDYMYRGEVNISQDQLAALLKAAESLQIKGLSDNRTG---GGVAPKPE 129
            |||.|::||.:.:|:|::::||:||:|:.|||:..|||.||:|:|:||::...|   ||.:..|.
  Fly   259 HPIIIMRDVSWSDLKALVEFMYKGEINVCQDQINPLLKVAETLKIRGLAEVSAGRGEGGASALPM 323

  Fly   130 SS--GHHRGGKLSGAYTLEQ------------TKRARLATGGAMDTSGDVSGSREGSSSPSRRRR 180
            |:  ......:|:.|..:.|            .||.||...|.:|.              ::|:|
  Fly   324 SAFDDEDEEEELASATAILQQDGDADPDEEMKAKRPRLLPEGVLDL--------------NQRQR 374

  Fly   181 KVRRRSMENDAHDNSNSSVLQAAASNQSILQQTGA----GLAVS---ALVTTQLSSGPAAGTSSQ 238
            |..|        |.|.::...:....:|.:.:.|:    |.:.|   |:.|:.:...|.|..:.|
  Fly   375 KRSR--------DGSYATPSPSLQGGESEISERGSSGTPGQSQSQPLAMTTSTIVRNPFASPNPQ 431

  Fly   239 ----------ASSTQQQQPL-TSTNVTKKTESAKLTSSTAAPASGASASAAV------------Q 280
                      |.:.|::.|. |:|..:.....|.:.|    |..|.:..:|:            .
  Fly   432 TLEGRNSAMNAVANQRKSPAPTATGHSNGNSGAAMHS----PPGGVAVQSALPPHMAAIVPPPPS 492

  Fly   281 QAHLHQQQ--AQ---TTSDAINTENVQAQSQGGAQGVQGDDEDIDEGSAVGGPNSATGPNPASAS 340
            ..|.|.||  ||   ..|.|:.:....|.:..||.|..|...  ..||....|...||...:.|.
  Fly   493 AMHHHAQQLAAQHQLAHSHAMASALAAAAAGAGAAGAGGAGS--GSGSGASAPTGGTGVAGSGAG 555

  Fly   341 ASAVHAGVVVKQLASVVDKSSSNHKHKIKDNSVSSVGSEMVIEPKAEYDDDAHDENVEDLTLDEE 405
            |:.                 .|:|             .:|.|:|:           :.::..:||
  Fly   556 AAV-----------------GSHH-------------DDMEIKPE-----------IAEMIREEE 579

  Fly   406 DMTMEELDQTAGTSQGGEGSSQTYATWQHDRSQDELGLMAQDAQQRDPQASKQDKGEQTEGAQDE 470
            ...|.|.....|. .|...::...|:...|..|.:|..|.|.....:.|...|....:..|....
  Fly   580 RAKMIESGGHGGW-MGAAAAATGAASVAADSYQYQLQSMWQKCWNTNQQNLVQQLRFRERGPLKS 643

  Fly   471 FELDDCLLESNDIVITQNKDG----------------FVLHVKKLGNITAAKLEENQAVAQQQGQ 519
            :. .:.:.|:   :.:..|:|                |||:..::.|:....|:
  Fly   644 WR-PEAMAEA---IFSVLKEGLSLSQAARKFDIPYPTFVLYANRVHNMLGPSLD----------- 693

  Fly   520 AAVTVTGPAGQPTPTITELLNAAAASHSEPKPTLTTLTSTPIKLPSSECELI------NIKKIIP 578
                  |.| .|.|            .:..:|....|...|.:|..|..:.:      .||:.:.
  Fly   694 ------GGA-DPRP------------KARGRPQRILLGMWPEELIRSVIKAVVFRDYREIKEDMS 739

  Fly   579 A----------------TTTIATHH---------------PHTSSTIIHPHHII--QHVSQEPHH 610
            |                |||...|.               |...|.:......:  |.:||:..|
  Fly   740 AHQYANGQGHGTYIGGGTTTNGYHSAAAAKLAAQNAALAPPDAGSPLSSMTETLRRQILSQQQQH 804

  Fly   611 QEHHQQHQTIHIEEVPQTSQQHHQQQHHHQLQTVQPTHTQVQSIITAHPGQTINLVGLRNVQLAD 675
            |:||||             |.||||         ||:|.|.||
  Fly   805 QQHHQQ-------------QAHHQQ---------QPSHHQQQS---------------------- 825

  Fly   676 SKPIASRIRYSRGKIIGPTVQNLQIVETHEPIQHQHHELSDGTKYEISEIDLNNPNASAAIISDL 740
                             |..|::.:.::  |...|..|:.|    ::|        |:||:.:..
  Fly   826 -----------------PHAQSMNMYKS--PAYLQRSEIED----QVS--------AAAAVAAAA 859

  Fly   741 VKYAEID-----DIELPDGTKIGIGFAPSEITEHMQTSGG 775
            .|:.:..     ...|||.:.:|:...|.......:.|||
  Fly   860 AKHQQQQGERRGSENLPDLSALGLMGLPGLNVMPSRGSGG 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lola	NP_788308.3	BTB	22..117	CDD:279045	50/94 (53%)
		BTB	33..117	CDD:197585	44/83 (53%)
		C2H2 Zn finger	905..925	CDD:275368
		C2H2 Zn finger	935..955	CDD:275368
bab2	NP_523879.2	BTB	213..309	CDD:279045	50/95 (53%)
		BTB	224..309	CDD:197585	44/84 (52%)
		HTH_psq	645..690	CDD:283007	7/48 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10615
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.010