DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lola and CG6765

DIOPT Version :9

Sequence 1:	NP_788308.3	Gene:	lola / 44548	FlyBaseID:	FBgn0283521	Length:	970	Species:	Drosophila melanogaster
Sequence 2:	NP_001261582.1	Gene:	CG6765 / 38971	FlyBaseID:	FBgn0035903	Length:	681	Species:	Drosophila melanogaster

Alignment Length:	732	Identity:	149/732 - (20%)
Similarity:	250/732 - (34%)	Gaps:	232/732 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QQFCLRWNNHQSTLISVFDTLLENETLVDCTLAAEGKF-----------LKAHKVVLSACSPYFA 58
            :.:.|:|::|.:.|.|...||.:||...|..|.:....           :.|||.:|||.|.:||
  Fly     4 ENYHLKWDSHLTYLNSSIATLYKNEKFADVVLYSSYNSSGIPSDIPTVGISAHKFILSASSQFFA 68

  Fly    59 TLLQEQYDKHP-----IFILKDVKYQELRAMMDYMYRGEVNISQDQLAALLKAAESLQIKGL--S 116
            |:.:.....:|     :.:..|:.::.::.::.|||.||..:|.|.|..:|:..|.|:|:||  :
  Fly    69 TMFETAPITNPNGVLYVVLPPDLSHRAIQILVQYMYSGEATVSNDILNEVLRGGEILKIRGLCRT 133

  Fly   117 DNRTGGG------VAPKPES-SGHHRGGKLSGAYTLEQTKRA-------RLATGGAMDTSGDVSG 167
            .:..|||      ....|.| :||....:.|..|....|:.|       ..:|..| ...||:..
  Fly   134 SSSNGGGSGSVVTTTHHPHSLAGHLHPREASTMYMSNGTRTALPPPPPPPQSTMSA-QLQGDLYA 197

  Fly   168 SREGSSSPSRRRRKVRRRSMENDAHDNSNSSVLQAAASNQSILQQTGAGLAVSALVTTQLSSGPA 232
            |:.|.|:         |.::::. |.:|:.|.|     |....||...||..|.:.    ...|.
  Fly   198 SKPGGST---------RFALDHH-HLSSHHSHL-----NHHNPQQQFRGLGASVMP----KDSPV 243

  Fly   233 AGTSSQASSTQQQQPLTSTNVTKKTESAKLTSST--------------AAPASGASASAAVQQAH 283
            ...|.:.::        .|.:.....|:||..|.              |||....|.|
  Fly   244 IIKSPKLAA--------HTGLLTVASSSKLGISVNKEVAIDPEDKCCFAAPGQLESQS------- 293

  Fly   284 LHQQQAQTTSDAINTENVQAQSQGGAQGVQGDDEDIDEGSAVGGPNSATGPNPAS------ASAS 342
             |.....||:..:          ||.            |.:||| :.|....|.|      .|:.
  Fly   294 -HPPPPTTTTTTV----------GGG------------GGSVGG-SGAPPSQPISICTEVGCSSC 334

  Fly   343 AVHAGVVVKQLASVVDKSSSNHKHKIKDNSVSSV-----GSEMVIEPKAEYDDDAHDENVED--- 399
            .:.||....|..:.:.::....:...:.|.|..|     ..|...|...:|.:..|.|:|..
  Fly   335 PLTAGPGADQAETTLRRTEYEEQALRERNEVGLVFERRLRRESACERSRDYYEAPHFEHVVSSRL 399

  Fly   400 -------------------------LTLDEEDMTMEELDQTAGTSQGGEGSSQTYATWQHDRSQD 439
                                     ||:.:|..........|.::             .::.:.:
  Fly   400 AATPPPPPQQAPPSHPPTLRHPHNFLTIKQEPTDWSNNPPNASSA-------------SNNNNLE 451

  Fly   440 ELGLMAQDAQQRDPQAS------KQDKGEQTEGAQDEFELDDCLLESNDIVITQNKDGFVLHVKK 498
            ||.| |...|..|.:.|      .:|:|..:|.:::.     .|.:.|:.             |:
  Fly   452 ELPL-ASPKQPLDFKMSAVKLEVNRDRGTPSEESEEH-----TLRDYNNF-------------KQ 497

  Fly   499 L--GNITAAKLEENQAVAQQQGQAAVTVTGPAGQPTPTITELLNAAAASHSEPKPTLTTLTSTPI 561
            |  ..|.....|:.:.:.:..|.       .||.||......|..::||.|      ||..|:.:
  Fly   498 LLVCEICQKSFEDTKMLVRHLGT-------HAGDPTGGTERNLLPSSASGS------TTSASSNL 549

  Fly   562 KLPSSECELINIKKIIPATTTIATHHPHTSSTIIHPHHIIQHVSQEPHHQEHHQQHQTIHIE--- 623
            .|.|       :|..:|...                    :.|||:.::.:|  .|.|:..:
  Fly   550 ALRS-------VKTYVPKKR--------------------RRVSQQENNMDH--DHVTLLCDLCS 585

  Fly   624 ---EVPQTSQQHHQQQH 637
               :.|....:|...||
  Fly   586 TSFDTPAEWVRHMNSQH 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lola	NP_788308.3	BTB	22..117	CDD:279045	32/112 (29%)
		BTB	33..117	CDD:197585	28/101 (28%)
		C2H2 Zn finger	905..925	CDD:275368
		C2H2 Zn finger	935..955	CDD:275368
CG6765	NP_001261582.1	BTB	24..132	CDD:279045	31/107 (29%)
CG6765	NP_001261582.1	BTB	53..130	CDD:197585	24/76 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.010