DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lola and BtbVII

DIOPT Version :9

Sequence 1:	NP_788308.3	Gene:	lola / 44548	FlyBaseID:	FBgn0283521	Length:	970	Species:	Drosophila melanogaster
Sequence 2:	NP_647774.2	Gene:	BtbVII / 38376	FlyBaseID:	FBgn0263108	Length:	907	Species:	Drosophila melanogaster

Alignment Length:	1029	Identity:	234/1029 - (22%)
Similarity:	357/1029 - (34%)	Gaps:	296/1029 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QQFCLRWNNHQSTLISVFDTLLENETLVDCTLAAEGKFLKAHKVVLSACSPYFATLLQEQYDKHP 69
            |||||||||||...|||..:||.|.||||.||||||:.|:|||:||||||.||..|......:||
  Fly     4 QQFCLRWNNHQPNFISVCSSLLHNGTLVDVTLAAEGRQLQAHKIVLSACSSYFQALFTTNPCQHP 68

  Fly    70 IFILKDVKYQELRAMMDYMYRGEVNISQDQLAALLKAAESLQIKGLSDNRTGGGVAPKPESSGHH 134
            |.|||||:|.:|:.|:|:||.||||:||:||..:||.||.|:||||::..|......|.:|....
  Fly    69 IVILKDVQYDDLKTMVDFMYYGEVNVSQEQLPHILKTAEMLKIKGLAEMPTDPANLTKSDSKSST 133

  Fly   135 RGGKLSGAYTLEQTKRARLATGGAMDTSGDV---SGSREG----SSSPSRRRRKVRRRSMENDAH 192
            .|.::.|.        |.:.| ||.:::|.:   |||..|    |||.:::.::.:::..:..|.
  Fly   134 DGTEMVGG--------AGVGT-GAGNSAGSLGAGSGSSVGDSLWSSSEAQQFQQQQQQQAQQQAQ 189

  Fly   193 DNSNSSVLQAAASNQSILQQTGAGLAVSALVTTQLSSGPAAGTSSQASSTQQQQPLTSTNVTKKT 257
            ...:....|     |.:.||                       ..||...||||.....:..::
  Fly   190 QQHHHHQQQ-----QQLQQQ-----------------------QQQAQQQQQQQQHHHHHHQQQ- 225

  Fly   258 ESAKLTSSTAAPASGASASAAVQQAHLHQQQ------AQTTSDAINTENVQAQSQGGAQGVQGD- 315
                           .|..|...|.|.||.:      :..||.|...:.::..|..|:    ||
  Fly   226 ---------------QSGQAQAAQTHHHQMRRTPSPLSAGTSPATRRKRLRKSSNNGS----GDR 271

  Fly   316 -------DEDIDEGSAVGGP-------NSATGPNPASASASAVHAGVVVKQLASVVDKSSSNHKH 366
                   :..:|.||..|..       |..|.......:..::||..::|:.||
  Fly   272 NNAEEQHNSSLDAGSGAGNAGLSLAQMNQMTFGAGGGLAGHSLHAAKLLKESAS----------- 325

  Fly   367 KIKDNSVSSVGSEMVIEPKAEYDDDAHD----ENVEDLTLDEEDMTMEELDQTAGTSQGGEGSSQ 427
                       :|:..:|:....||.|.    :...::.:...:.|| .||.:.||:..
  Fly   326 -----------AELEQQPQDSDLDDGHGHLHMQIKPEVDIGGVNQTM-PLDISGGTTPS------ 372

  Fly   428 TYATWQHD-----RSQDELGLMAQDAQQRDPQASKQDKGEQTEGAQDEFELD---------DCLL 478
                 :||     .|..|    ...|....|..........:.|....||..         :|
  Fly   373 -----EHDAPNSQSSHSE----PSPAHAPHPPHPPLGAASSSSGGSGSFERSFSIGGVGSVEC-- 426

  Fly   479 ESNDIVITQNKDGFVLHVKKLGNITAAKLEENQAVAQQQGQAAVTVTGPAGQPTPTITELLNAAA 543
                     :.||.......:|.      :.|:.:.:|                |.:....::.:
  Fly   427 ---------DPDGTPSSPAVMGT------KRNRVLTRQ----------------PRVKRDSDSIS 460

  Fly   544 ASHS-EPKPTLTTLTSTPIKLPSSECELINIKKIIPAT----TTIATHHPHTSSTIIHPHHIIQH 603
            :::. .|....|||...|          .|......||    :|..:||.|..|.:.|.||::
  Fly   461 STNQISPDTAATTLDFDP----------FNAAGATSATARDYSTTGSHHLHHQSAVHHHHHLL-- 513

  Fly   604 VSQEPHHQEHHQQ------HQTIHIEEVPQTSQQHHQQQHHHQLQTVQPTHTQVQSIITAHPGQT 662
             :..|..:.|..:      ..|.|:..|| :|..:..:||.      .|...:..::..|..|.
  Fly   514 -TVPPRIERHASEPAPSLAPSTPHLLSVP-SSTPYLIKQHS------DPLLPRQSALHMAGSGS- 569

  Fly   663 INLVGLRNVQLADSKPIASRIRYSRGKIIGPTVQNLQIVETHEPIQHQHHELSDGTKYEISEIDL 727
                |..:.....|.|.|...|.....:.|   .|...| |..|:.|.||
  Fly   570 ----GSSSAMATGSNPFAPLHRQYSHPLSG---SNASYV-TPAPLHHPHH--------------- 611

  Fly   728 NNPNASAAIISDLVKYAEIDDIELPDGTKIGIGFAPSEITEHMQTS--------GGETHITTIEH 784
                                 |.||:.........|:..::::..:        ..||..|....
  Fly   612 ---------------------ISLPESIYASGSPPPAGSSQYLVPTRVVACPVVSSETAATPTNA 655

  Fly   785 EPQELQTVHQHEQTQQTHHIHAGQLQTHHIQTVVQSSSGQQQHDQQQHH-----QHHSIELQDDD 844
            .|....||........:.:.......:.|..:...|......|:::..|     :...:|....:
  Fly   656 SPGSSSTVSAAVSVVTSPNAGLQNSASRHPLSPTFSIGSDVAHERRSPHSPSISRSQVVERAGKN 720

  Fly   845 GVE-----------------TITPEEL--GMHDSSKSYTILTTRPMKEE----SEHDPSGMTYEL 886
            ..|                 :||...|  |....|.|:..|.|..:|.|    |...|......:
  Fly   721 PAEAANGGGSRLRTSKSASGSITGTHLHPGQATMSSSFEHLPTLRVKNEELQRSVSSPQTQREII 785

  Fly   887 SLSD--SSLGPCDDPESRYVCRHCGKKYRWKSTLRRHENVECGGKEPCHPCPYC 938
            :|.:  ||..|...|.....|..|     | :|:..|..: ...|...| ||.|
  Fly   786 TLENPRSSHCPVIRPGPALGCNFC-----W-NTIDGHGRI-LRRKTKYH-CPEC 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lola	NP_788308.3	BTB	22..117	CDD:279045	57/94 (61%)
		BTB	33..117	CDD:197585	51/83 (61%)
		C2H2 Zn finger	905..925	CDD:275368	5/19 (26%)
		C2H2 Zn finger	935..955	CDD:275368	3/4 (75%)
BtbVII	NP_647774.2	BTB	24..117	CDD:279045	57/92 (62%)
BtbVII	NP_647774.2	BTB	32..117	CDD:197585	51/84 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10615
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.010