DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lola and bab1

DIOPT Version :9

Sequence 1:	NP_788308.3	Gene:	lola / 44548	FlyBaseID:	FBgn0283521	Length:	970	Species:	Drosophila melanogaster
Sequence 2:	NP_728565.1	Gene:	bab1 / 38116	FlyBaseID:	FBgn0004870	Length:	977	Species:	Drosophila melanogaster

Alignment Length:	1039	Identity:	218/1039 - (20%)
Similarity:	351/1039 - (33%)	Gaps:	372/1039 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QQFCLRWNNHQSTLISVFDTLLENETLVDCTLAAEGKFLKAHKVVLSACSPYFATLLQEQYDKHP 69
            |||||||||:|:.|.::||.||:||..||.|||.:|:.:||||:|||||||||.|||.|...:||
  Fly   100 QQFCLRWNNYQTNLTTIFDQLLQNECFVDVTLACDGRSMKAHKMVLSACSPYFQTLLAETPCQHP 164

  Fly    70 IFILKDVKYQELRAMMDYMYRGEVNISQDQLAALLKAAESLQIKGLSDNRTGGGVAPKPESSGHH 134
            |.|::||.:.:|:|::::|||||:|:||||:..||:.||.|:::||:|
  Fly   165 IVIMRDVNWSDLKAIVEFMYRGEINVSQDQIGPLLRIAEMLKVRGLAD----------------- 212

  Fly   135 RGGKLSGAYTLEQTKRARLATGGAMDTSGD-VSGSREGSSSPSRRRRKVRRRSMENDAHDNSNSS 198
                         ......||..|...|.: :..|.:.|:|.||..            ||.
  Fly   213 -------------VTHMEAATAAAAAASSERMPSSPKESTSTSRTE------------HDR---- 248

  Fly   199 VLQAAASNQSILQQTGAGLAVSALVTTQLSSGPAAGTSSQASSTQQQQPLTSTNVTKKT-ESAKL 262
              :..|.......|....|..|.....:|...|          .::||   ..||.|:. .||..
  Fly   249 --EREAEELLAFMQPEKKLRTSDWDPAELRLSP----------LERQQ---GRNVRKRRWPSADT 298

  Fly   263 TSSTAAPASGASASAAVQQAHLHQQQAQTTSDA--INTENVQAQSQGGAQGVQGDDE------DI 319
            ..:..||.|..|:..|.::..|.|::.:...|.  :........|.|...|.....|      |:
  Fly   299 IFNPPAPPSPLSSLIAAERMELEQKERERQRDCSLMTPPPKPPMSSGSTVGATRRLETAIHALDM 363

  Fly   320 DEGSAVGGP---------------------------------NSATGPNPASASASAVH------ 345
            ...:|..||                                 :::..|:|:..:.||.|
  Fly   364 PSPAATPGPLSRSSRPHSQSPQQQQAQQQGQLPLPLPLHPHHHASPAPHPSQTAGSAHHPASPAG 428

  Fly   346 ----------AGVVVKQLASVVDKSSSN--------HKH----------------KIKDNSVSSV 376
                      |....::|:.:....|:.        |.|                .:.....||:
  Fly   429 DSRFPLGPAAAMAAARELSGLGPGPSAEPRLPPPPPHHHGGGGVGGGGVGGGGAGGVGSGGGSSL 493

  Fly   377 GSEMVIEPKAEYDDDAHDENVEDLTLDEEDMTMEE-----LDQTAGTSQGGEGSSQTYATWQHDR 436
            ..::.|:|           .:.::..:||...|.|     :..|..|........|..:.||...
  Fly   494 ADDLEIKP-----------GIAEMIREEERAKMMENSHAWMGATGSTLAADSYQYQLQSMWQKCW 547

  Fly   437 SQDELGLMAQDAQQRDPQASKQDKGEQTEGAQDEFELDDCLLESNDIVITQNKDG---------- 491
            :.::..:.....::|.|..|.:               .:.:.|:   :.:..|:|
  Fly   548 NTNQNLMHHMRFRERGPLKSWR---------------PETMAEA---IFSVLKEGLSLSQAARKY 594

  Fly   492 ------FVLHVKKLGNITAAKLEENQAVAQQQGQAAVTVTGPAGQPTP----------------- 533
                  |||:..::.|:....::....:.            |.|:..|
  Fly   595 DIPYPTFVLYANRVHNMLGPSIDGGPDLR------------PKGRGRPQRILLGIWPDEHIKGVI 647

  Fly   534 -TIT-----ELLNAAAASHSEP----KPTLTTLTSTPIKLPSSECELINIKKIIPATTTIATHH- 587
             |:.     ::.:.:.|:|..|    .|.. .|...|:..|.:...|..      |.:::|..:
  Fly   648 KTVVFRDTKDIKDESLAAHMPPYGRHSPAF-PLQDLPLSYPGASGALAG------APSSMACPNG 705

  Fly   588 --PHTSSTIIHPHHIIQHVSQEPHHQEHHQQHQTIHIEEVPQTSQQHHQQQHHHQLQTVQPTHTQ 650
              |.|...:...    ||:||                |.....:...|..:...|:..|.|....
  Fly   706 SGPQTGVGVAGE----QHMSQ----------------ETAAAVAAVAHNIRQQMQMAAVPPGLFN 750

  Fly   651 VQSIITAHPGQTINLVGLRNVQLADSKPIASRIRYSRGKIIGPTVQNLQIVETHEPIQHQHHELS 715
                :..|||..   .|:.||      |.|:..|.|    |.|.:.:                 .
  Fly   751 ----LPPHPGVG---GGVGNV------PGAAGGRAS----ISPALSS-----------------G 781

  Fly   716 DGTKYEISEIDLNNPNASAAIISDLVKYAEIDDIELPDGTKIGIGFAPSEITEHMQTSGGETHIT 780
            .|.::..|      |...|.::.:           ||....:.:
  Fly   782 SGPRHAPS------PCGPAGLLPN-----------LPPSMAVAL--------------------- 808

  Fly   781 TIEHEPQELQTVHQHEQ----TQQTHHIHAGQLQTHHIQTVVQSSSGQQQHDQQQHHQ-HHSIEL 840
               |..|:.|..|.|.|    .||..|:|      ||.|        |||..|||||| .|.:..
  Fly   809 ---HHQQQQQAAHHHMQQLHLQQQQAHLH------HHQQ--------QQQQQQQQHHQGGHQVAH 856

  Fly   841 QDDDGV---ETITPEELGMHDSSKSYTILTTRPMKEESE--HDPSG------MTYELSLSDSSL 893
            :...|.   .:.:...:|.|.:.|:    .:.|::.|:.  |.|.|      .:|:...|.|.|
  Fly   857 KSGFGASSSSSASSSSMGQHHAPKA----KSSPLRSETPRLHSPLGDLGLDMASYKREFSPSRL 916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lola	NP_788308.3	BTB	22..117	CDD:279045	54/94 (57%)
		BTB	33..117	CDD:197585	47/83 (57%)
		C2H2 Zn finger	905..925	CDD:275368
		C2H2 Zn finger	935..955	CDD:275368
bab1	NP_728565.1	BTB	117..216	CDD:279045	55/128 (43%)
		BTB	128..213	CDD:197585	48/114 (42%)
		HTH_psq	569..614	CDD:283007	7/62 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10615
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.010