DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lola and chinmo

DIOPT Version :9

Sequence 1:	NP_788308.3	Gene:	lola / 44548	FlyBaseID:	FBgn0283521	Length:	970	Species:	Drosophila melanogaster
Sequence 2:	NP_001188680.1	Gene:	chinmo / 33343	FlyBaseID:	FBgn0086758	Length:	840	Species:	Drosophila melanogaster

Alignment Length:	689	Identity:	159/689 - (23%)
Similarity:	251/689 - (36%)	Gaps:	195/689 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDDDQQFCLRWNNHQSTLISVFDTLLENETLVDCTLAAEGKFLKAHKVVLSACSPYFATLLQEQY 65
            ||..|||||:||:..|.|...|..|.:::.|.|..|:.:|...||||::|:|||..||.|    :
  Fly     1 MDPQQQFCLKWNSFSSNLAITFSNLFKSDLLADVILSCDGVVFKAHKLILAACSKKFADL----F 61

  Fly    66 DKHP-----IFILKDVKYQELRAMMDYMYRGEVNISQDQLAALLKAAESLQIKGLSDNRTGGGVA 125
            :..|     :.||:......:.|::::||:|||::||:.|.:.||:|||||:||||
  Fly    62 ENTPTNGQCVIILEATTPDNMAALLEFMYKGEVHVSQEALNSFLKSAESLQVKGLS--------- 117

  Fly   126 PKPESSGHHRGGKLSGAYTLEQTKRARLATGGAMDTSGDVSGSREGSSSPSRRRRKVRRRSMEND 190
                                  |:..|||...|....||:|    ...||:      .|||:.|.
  Fly   118 ----------------------TETGRLAAQQAQQHMGDLS----PLDSPT------GRRSVRNS 150

  Fly   191 AHDNSNSSV-------LQAAASNQSILQQTGAGLAVSALVTTQLSSGPAAGTSSQASSTQQQQPL 248
            ....|:|.|       |...|:..:.:...|.|..:| |.......|.||..::.|||....  .
  Fly   151 LSGGSSSIVPGGVGIGLGGGATGANSMSGMGIGNGLS-LAGMAAGGGMAAAANAAASSLSTL--A 212

  Fly   249 TSTNVTKKTES--AKLTSSTAAPASGASASAAVQQAHLHQQQAQTTSDAINTENVQAQSQGGAQG 311
            .|.|:..:..|  |.:.|.:||...|:.:..|                            |...|
  Fly   213 ASANIVDRCGSAGANIISGSAAGIGGSHSGGA----------------------------GNGSG 249

  Fly   312 VQGDDEDIDEGSAVGGPNSATGPNPASASASAVH-----AGVVVKQLASVVDKSSSNHKHKIKDN 371
            ..|..     |:.||......||....:.|.|.|     .|::.::..|::....|:....:...
  Fly   250 TVGIG-----GNGVGSGGGNNGPISLGSGAGAAHHLGGSTGILKQECDSLMHPGGSSSSSGMGYT 309

  Fly   372 SVSSVGSEMVIEP-------KAEYDDDAHDENV-EDLTLDEEDMTMEELDQTAGTSQGGEGSSQT 428
            .|..:...:..||       ::.|.:.....:| .|.:...|..:..........|.....::.|
  Fly   310 HVPPIYRPINYEPPRKRAIVRSPYSEQEQRGSVLRDGSKSSECPSPINKPPYHRPSSSASSTAPT 374

  Fly   429 YATWQHDRSQDELGLMAQDAQQRDPQASKQD---------------------KGEQTEGAQDEFE 472
            .|...|             :::..||:|:.:                     |.|:..|:.:|..
  Fly   375 EADTMH-------------SERASPQSSRYENHSPSTTAGNGNATSSLERIVKSERNNGSANEAN 426

  Fly   473 LDDCLL--ESNDIVITQNKDGFVLHVKKLGNI---------------TAAKLEEN-QAVAQQQGQ 519
            .||..|  ||.|   ...:|   |.| ||.|:               |...|.|| :|.......
  Fly   427 DDDRELMDESTD---NGAED---LRV-KLENLKYSPPPPPNSNTSSTTPNTLLENLKADGTLSSN 484

  Fly   520 AAVTVTGPAGQPTPTITELLNAAAASHSEPKPTLTTLTSTPIKLPSSECELINIKKIIPATTTIA 584
            .|.:: .||        ::||...|:....|.::.|....  ||....|:     ::....|.:.
  Fly   485 LAASI-APA--------DMLNVWNATKMNNKNSVNTADGK--KLKCLYCD-----RLYGYETNLR 533

  Fly   585 TH----H-------PHTSSTIIHPHHIIQHVSQEPHHQE 612
            .|    |       |....|....:.:.:|:::| |.||
  Fly   534 AHIRQRHQGIRVPCPFCERTFTRNNTVRRHIARE-HKQE 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lola	NP_788308.3	BTB	22..117	CDD:279045	39/99 (39%)
		BTB	33..117	CDD:197585	36/88 (41%)
		C2H2 Zn finger	905..925	CDD:275368
		C2H2 Zn finger	935..955	CDD:275368
chinmo	NP_001188680.1	BTB	22..116	CDD:279045	37/97 (38%)
		BTB	33..116	CDD:197585	34/86 (40%)
		C2H2 Zn finger	519..540	CDD:275368	3/25 (12%)
		C2H2 Zn finger	547..568	CDD:275368	4/21 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	63	1.000	Domainoid score	I10232
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.010