DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lola and mamo

DIOPT Version :9

Sequence 1:	NP_788308.3	Gene:	lola / 44548	FlyBaseID:	FBgn0283521	Length:	970	Species:	Drosophila melanogaster
Sequence 2:	NP_572932.2	Gene:	mamo / 32353	FlyBaseID:	FBgn0267033	Length:	1553	Species:	Drosophila melanogaster

Alignment Length:	673	Identity:	185/673 - (27%)
Similarity:	269/673 - (39%)	Gaps:	172/673 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QQFCLRWNNHQSTLISVFDTLLENETLVDCTL-AAEGKFLKAHKVVLSACSPYFATLLQEQYDKH 68
            :.:||||||:||.|:.||..||::.:|||.|| .:||..::||||||||||.||.:|..|..:.|
  Fly     4 EHYCLRWNNYQSNLLGVFSQLLQDGSLVDVTLVCSEGTSIRAHKVVLSACSSYFQSLFLEHPEGH 68

  Fly    69 PIFILKDVKYQELRAMMDYMYRGEVNISQDQLAALLKAAESLQIKGLSDNRTGGGVAPKPESSGH 133
            .|.|||||::.||:.::::||:||||:...||:||||.||||::|||::.........:||
  Fly    69 LIVILKDVRFAELQTLVEFMYKGEVNVQYCQLSALLKTAESLKVKGLAEMTNQNTTLREPE---- 129

  Fly   134 HRGGKLSGAYTLEQTKRARLATGGAMDTSGDVSGSREGSSSPSRRRRKVRRRSMENDAHDNSNSS 198
                        .:..|.|...||     |....:.:.:.||                     ::
  Fly   130 ------------REPDRLRPQGGG-----GSGGSAHKAADSP---------------------AA 156

  Fly   199 VLQAAASNQSILQQTGAGLAVSALVT-TQLSSGPAAGTSSQASSTQQQQPLTSTNVTKKTESAKL 262
            .|.|.|:.|:   .|....|.:|..| |..|:..||.|::..::|.     .||..|....|:..
  Fly   157 ALDATAATQA---ATATATATAAAATSTSTSATSAAATAAATAATS-----ASTTATAAAGSSNT 213

  Fly   263 TSSTAAPASGASASAAVQQAHLHQQQAQTTSDAINTENVQAQSQGGAQGVQGDDEDIDEGSAVGG 327
            |::|||..:...|:||...|      |.::|.::.:....|.:...|.||...:|.....|:.||
  Fly   214 TTTTAATTTATCATAATSTA------ATSSSSSVTSAAAAAAAAASASGVAHSEEATSSSSSTGG 272

  Fly   328 ----PNSATGPNPASASASAVHAGVVVKQLASVVDKSSSNHKHKIKDNSVSSVGSEMVI--EPKA 386
                .:..:.|.||..| |.:|.       |..||.:....:   :.|....:.||.::  ..|.
  Fly   273 QKREASDRSSPTPAKRS-SRMHP-------ADKVDVAEDREQ---EQNQADELLSEELLGRNLKD 326

  Fly   387 EYDDDAH--DENVE---------DLTLDEEDMTMEELD-----------QTAGTS--QGG----E 423
            |.|||..  |||.|         |...|||:.|...||           ..|.|:  |||    .
  Fly   327 EEDDDVDELDENEETKLRGRDEDDDDEDEEEDTPMPLDLYQRPNVEPKSAAAATAAQQGGSNSLS 391

  Fly   424 GSSQTYATWQHDRSQDELGLMAQDAQQRDPQASKQDKGEQTEG--AQDEFELDDCLLESNDIVIT 486
            |||....|.....|.:........:...:...|.......:.|  |......|..:...:|   .
  Fly   392 GSSNACHTNSSSNSNNNNNNNNNSSSNNNNNTSSGKTSASSNGGTASSGGTADSVVAVDDD---D 453

  Fly   487 QNKDGFVLHVKKLGNITAAKLEENQAVAQQQGQAAVTVTGPAGQPTPTITELLNAAAASHSEPKP 551
            .:.||...|.::   :...:||  |.|.::.....|.|.|||......|.:.|     :|.
  Fly   454 DDDDGGHHHQRQ---VMDDRLE--QDVDEEDLDDDVVVVGPATAMARGIAQRL-----AHQ---- 504

  Fly   552 TLTTLTSTPIKLPSSECELINIKKIIPATTTIATHHPHTSSTIIHPHHIIQHVSQEPHHQEHHQQ 616
                                |::::         ||.|        ||.....||  ||..|.|.
  Fly   505 --------------------NLQRL---------HHTH--------HHAQHQHSQ--HHHPHSQH 530

  Fly   617 HQTIHIEEVPQTSQQHHQQQHHH 639
            |.|           .||||.|.|
  Fly   531 HHT-----------PHHQQHHTH 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lola	NP_788308.3	BTB	22..117	CDD:279045	52/95 (55%)
		BTB	33..117	CDD:197585	47/84 (56%)
		C2H2 Zn finger	905..925	CDD:275368
		C2H2 Zn finger	935..955	CDD:275368
mamo	NP_572932.2	BTB	21..118	CDD:279045	52/96 (54%)
		BTB	32..118	CDD:197585	47/85 (55%)
		C2H2 Zn finger	1082..1105	CDD:275368
		C2H2 Zn finger	1116..1137	CDD:275368
		C2H2 Zn finger	1149..1169	CDD:275368
		zf-C2H2	1469..1491	CDD:278523
		C2H2 Zn finger	1471..1491	CDD:275368
		zf-H2C2_2	1483..1506	CDD:290200
		C2H2 Zn finger	1499..1519	CDD:275368
		zf-H2C2_2	1511..1536	CDD:290200
		C2H2 Zn finger	1527..1547	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10615
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	4.010