DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lola and CG32121

DIOPT Version :9

Sequence 1:	NP_788308.3	Gene:	lola / 44548	FlyBaseID:	FBgn0283521	Length:	970	Species:	Drosophila melanogaster
Sequence 2:	NP_001097599.1	Gene:	CG32121 / 317867	FlyBaseID:	FBgn0052121	Length:	648	Species:	Drosophila melanogaster

Alignment Length:	754	Identity:	163/754 - (21%)
Similarity:	263/754 - (34%)	Gaps:	240/754 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DDDQQFCLRWNNHQSTLISVFDTLLENETLVDCTLAAEGKFLKAHKVVLSACSPYFATLLQE-QY 65
            |..|||||||:|||::|:|....||:...|.|.|::|||:.|:||:|||||||.:|..:.:. :.
  Fly    25 DSQQQFCLRWHNHQTSLLSTLPILLDQSHLTDVTISAEGRQLRAHRVVLSACSSFFMDIFRALEA 89

  Fly    66 DKHPIFILKDVKYQELRAMMDYMYRGEVNISQDQLAALLKAAESLQIKGLSDNRTGGGVAPKPES 130
            ..||:.|:....:..:.:::.:||.||||:.::|:..||..||:|.||||:|.:...  .||...
  Fly    90 SNHPVIIIPGASFGAIVSLLTFMYSGEVNVYEEQIPMLLNLAETLGIKGLADVQNNN--LPKTAR 152

  Fly   131 SGHHRGGKLSGAYTLEQTKRARLATGGAMDTSGDVSGSREGSSSPSRRRRKVRRRSMENDAHDNS 195
            ||       .|:|               |||:.:.|...|..::||.........|.......:.
  Fly   153 SG-------GGSY---------------MDTTNEKSSEFERPTTPSPTPTPTLTPSHTPTPSHSL 195

  Fly   196 NSSVLQAAASNQSILQQTGAGLAVSALVTTQLSSGPAAGTSSQASSTQQQQPL--TSTNVTKKTE 258
            ....|.:||.|..:|......:..|.:.||.|.:   ...|.|...:...|||  :.|.:.|.||
  Fly   196 PLPQLPSAALNTPLLANKLGSVNSSGMGTTPLEN---LFKSLQFYPSLLPQPLNFSQTALNKTTE 257

  Fly   259 -SAKLTSSTAAPASGASASAAVQQAHLHQQQAQTTSDAINTENVQAQSQGGAQGVQGD------- 315
             .||..                ||..|:|...|  .|.:.|:..      |::.::||
  Fly   258 LLAKYQ----------------QQCQLYQSGMQ--EDQLETDCF------GSKRLKGDSPPKELR 298

  Fly   316 -----------DEDIDEGSAVGGPNSATGPNPASASASAVHAGVVVKQLA---SVVDKSSSNHKH 366
                       .......|:...|...:.|||..|::....|...:...:   .||..||:::.
  Fly   299 RLEKSLLKNPKSSSTTNSSSSKSPQECSNPNPIVATSPVTLAPPTMAHFSPQLPVVKCSSASYP- 362

  Fly   367 KIKDNSVSSVGSEMVIEPKAEYDDDAHDENVEDLTLDEEDMTMEELDQTAGTSQGGEGSSQTYAT 431
                   |::|...:...|                        ..|...|.|....:.::|.:..
  Fly   363 -------SALGQGQLYSSK------------------------PPLYSAAVTPTAAQQAAQMHHH 396

  Fly   432 WQHDRSQDELGLMAQDAQQRDPQASKQDKGEQTEGAQDEFELDDCLLESNDIVITQNKDGFVLHV 496
            .|...|               |..|          |:|..:|.                   ||:
  Fly   397 PQPGPS---------------PYIS----------AEDHAKLQ-------------------LHI 417

  Fly   497 KKLGNITAAKLEENQAVAQQQGQAAVTVTGPAGQPTPTITELLNAAAASHSEPKPTLTTLT---- 557
            :                 |.|.:||......||           ..|...::.:|.|.:|:
  Fly   418 E-----------------QYQREAAAAAAAAAG-----------GMALVSAKSEPNLLSLSADRD 454

  Fly   558 ----STPIKLPSSECELINIKKIIPATTTIATH-----------HPHTSSTIIHPHHIIQHVSQE 607
                :.|||.||:       .|:.  .|....|           |..|...:.:..::..|||:.
  Fly   455 KSLATAPIKPPSN-------SKLY--ATCFICHKQLSNQYNLRVHLETHQNVRYACNVCSHVSRS 510

  Fly   608 PHHQEHHQQHQTIHIEEVPQTSQQHHQQQHHHQL-QTVQPT---------HTQVQSIITAHPGQT 662
               ::..::|.:......|...:...:::...:| .|..||         ||.....:...|..|
  Fly   511 ---KDALRKHVSYRHPGAPSPCENEARRKRVSKLAATTVPTSTPMSMSASHTVTSGDVGPAPATT 572

  Fly   663 INLVG--LRN-----------------VQLADSKPIASR 682
            :...|  .||                 |.:|:|.|.:.:
  Fly   573 LGCSGQEARNPYLFLPNQFQMAAAAAAVAVAESSPASGQ 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lola	NP_788308.3	BTB	22..117	CDD:279045	38/95 (40%)
		BTB	33..117	CDD:197585	35/84 (42%)
		C2H2 Zn finger	905..925	CDD:275368
		C2H2 Zn finger	935..955	CDD:275368
CG32121	NP_001097599.1	BTB	48..142	CDD:279045	38/93 (41%)
		BTB	56..149	CDD:197585	36/94 (38%)
		C2H2 Zn finger	474..494	CDD:275370	2/19 (11%)
		C2H2 Zn finger	501..518	CDD:275370	3/19 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9675
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.010