DRSC/TRiP Functional Genomics Resources

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Protein Alignment lola and Trl

DIOPT Version :10

Sequence 1:NP_788308.3 Gene:lola / 44548 FlyBaseID:FBgn0283521 Length:970 Species:Drosophila melanogaster
Sequence 2:NP_001261846.1 Gene:Trl / 2768981 FlyBaseID:FBgn0013263 Length:623 Species:Drosophila melanogaster


Alignment Length:735 Identity:162/735 - (22%)
Similarity:272/735 - (37%) Gaps:217/735 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 FCLRWNNHQSTLISVFDTLLENETLVDCTLAAEGKFLKAHKVVLSACSPYFATLLQEQYDKHPIF 71
            :.|.|.::.::|:|....|..:..||||||||.|:...|||:||.|.||:...||:....|||:.
  Fly     9 YSLTWGDYGTSLVSAIQLLRCHGDLVDCTLAAGGRSFPAHKIVLCAASPFLLDLLKNTPCKHPVV 73

  Fly    72 ILKDVKYQELRAMMDYMYRGEVNISQDQLAALLKAAESLQIKGLS------DNRTG--------- 121
            :|..|...:|.|:::::|||||::...||.:||:||:.|.|:||:      |:.|.         
  Fly    74 MLAGVNANDLEALLEFVYRGEVSVDHAQLPSLLQAAQCLNIQGLAPQTVTKDDYTTHSIQLQHMI 138

  Fly   122 ----------GGVAPKPESSGH-------HRGGKLSGAYTLEQTKRARLATGGAMDTSGDVSGSR 169
                      ..:|..|:.:.|       |..|::..|.|  ||..|     |...|......::
  Fly   139 PQHHDQDQLIATIATAPQQTVHAQVVEDIHHQGQILQATT--QTNAA-----GQQQTIVTTDAAK 196

  Fly   170 EGSS-----SPSRRRR-KVRRRS---------------MENDAHDNSNSSVLQAAASN------- 206
            ...:     .|:|:|: :|::.|               |......:.:.||.|....|       
  Fly   197 HDQAVIQAFLPARKRKPRVKKMSPTAPKISKVEGMDTIMGTPTSSHGSGSVQQVLGENGAEGQLL 261

  Fly   207 ---------------------QSILQQTGAGLAVSALVTTQLSSGPAAGTSSQASSTQQQQPLTS 250
                                 .:::..|.|..|...:...|.::|.:.|.:|...||.:.:....
  Fly   262 SSTPIIKSEGQKVETIVTMDPNNMIPVTSANAATGEITPAQGATGSSGGNTSGVLSTPKAKRAKH 326

  Fly   251 TNVTKKTESAKLTSSTAAPASGASASAAVQQA-----HLH-----------QQQAQTTSDAINTE 299
            ...|:|..|   .|.:..||:.....|.::|:     ||.           ::::::.:|.....
  Fly   327 PPGTEKPRS---RSQSEQPATCPICYAVIRQSRNLRRHLELRHFAKPGVKKEKKSKSGNDTTLDS 388

  Fly   300 NVQAQSQGGAQGVQGDDEDIDEGSAVGGPNSATGPNPASASASAVHAGVVVKQLASVVDKSSSNH 364
            :::..:........|.|.....||| ||.:|||....:|:.:|...:|.:          |||..
  Fly   389 SMEMNTTAEGDNTVGSDGAGGAGSA-GGQSSATSGKKSSSGSSGSGSGAL----------SSSGS 442

  Fly   365 KHKIKDNSVSSVGSEMVIEPKAEYDDDAHDENVEDLTLDEEDMTMEELDQTAGTSQGGEGSSQTY 429
            ..:::  :|.|:.:...::.|.  |.||..:.      .::....::..|.|.|..|..|     
  Fly   443 VPQVQ--TVQSLHTLQGVQVKK--DPDAQQQQ------QQQQQQQQQQQQQAMTVSGATG----- 492

  Fly   430 ATWQHDRSQDELGLMAQDAQQRDPQASKQDKGEQTEGAQDEFELDDCLLESNDIVITQNKDGFVL 494
                        |.:.|..||...|..:|.:.:|.:..|         |:.:.|:.:.       
  Fly   493 ------------GQVQQQVQQVQQQVQQQQQQQQQQQQQ---------LQHHQIIDSS------- 529

  Fly   495 HVKKLGNITAAKLEENQAVAQQQGQAAVTVTGPAGQPTPTITELLNAAAASHSEPKPTLTTLTST 559
                 ||||.|......|.|.|| ||       |||....:      |.:..||        :..
  Fly   530 -----GNITTATTSAQAAAAAQQ-QA-------AGQQQQLV------AQSDGSE--------SGA 567

  Fly   560 PIKLPSSECELINIKKIIPATTTIATHHPHTSSTIIHPHHIIQHVSQEPHHQEHHQQHQTIHIEE 624
            |:.:                 ..:.|...|.....::..:|.....|:|..|:..||.|      
  Fly   568 PLSI-----------------AQVQTLQGHQIIGNLNQVNITDFQQQQPQQQQQQQQQQ------ 609

  Fly   625 VPQTSQQHHQQQHHHQLQTV 644
                 ||..|||...| ||:
  Fly   610 -----QQQQQQQQQTQ-QTL 623

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
lolaNP_788308.3 BTB_POZ_BAB-like 31..114 CDD:349624 39/82 (48%)
C2H2 Zn finger 905..925 CDD:275368
zf-H2C2_5 935..957 CDD:404746
C2H2 Zn finger 935..955 CDD:275368
TrlNP_001261846.1 BTB_POZ_BAB-like 33..116 CDD:349624 39/82 (48%)
GAGA 319..372 CDD:462719 10/55 (18%)
Blue background indicates that the domain is not in the aligned region.

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