DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lola and ZBTB20

DIOPT Version :9

Sequence 1:	NP_788308.3	Gene:	lola / 44548	FlyBaseID:	FBgn0283521	Length:	970	Species:	Drosophila melanogaster
Sequence 2:	NP_001157814.1	Gene:	ZBTB20 / 26137	HGNCID:	13503	Length:	741	Species:	Homo sapiens

Alignment Length:	857	Identity:	163/857 - (19%)
Similarity:	274/857 - (31%)	Gaps:	282/857 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SVFDTLLENET---LVDCTLAAEGKFLKAHKVVLSACSPYFATLLQEQYDKHPIFILKDVKYQEL 81
            ||.:||.|...   ..|.|:...|..|:||:.||:|.||:|...|...|.  .|.|...|..|.:
Human    89 SVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYS--DIEIPSVVSVQSV 151

  Fly    82 RAMMDYMYRGEVNISQDQLAALLKAAESLQIKGLSDNRTG------GGVAPKPESSGHHRGGKLS 140
            :.::|:||.|.:.:||.:...:|.||..||||.:.|..|.      |.|.|..:.||
Human   152 QKLIDFMYSGVLRVSQSEALQILTAASILQIKTVIDECTRIVSQNVGDVFPGIQDSG-------- 208

  Fly   141 GAYTLEQTKRARLATGGAMDTSGDVSGSREG--SSSPSRRRRKVRRR----SMENDAHDNSNSSV 199
                 :.|.|....:|    |||..|.:..|  .|.|.....::...    ||:|.:.:.|..|
Human   209 -----QDTPRGTPESG----TSGQSSDTESGYLQSHPQHSVDRIYSALYACSMQNGSGERSFYS- 263

  Fly   200 LQAAASNQSILQQTGAGLAVSALVTTQLSSGPAAGTSSQASSTQQQQPLTSTNVTKKTESAKLTS 264
             .|..|:    .:|..||                     ......:.|...|.:.::::..:...
Human   264 -GAVVSH----HETALGL---------------------PRDHHMEDPSWITRIHERSQQMERYL 302

  Fly   265 STAAPASGASASAAVQQAHLHQQQAQTTSDAINTENVQAQSQGGAQGVQGDDEDIDEGSAVGGPN 329
            ||..           :..|..:|
Human   303 STTP-----------ETTHCRKQ------------------------------------------ 314

  Fly   330 SATGPNPASASASAVHAGVVVKQLASVVDKSSSNHKHKIKDNSVSSVGSEMVIEPKAEYDDDAHD 394
                |.|           |.::.|                      ||:   |..|.|.:|| :|
Human   315 ----PRP-----------VRIQTL----------------------VGN---IHIKQEMEDD-YD 338

  Fly   395 ----ENVEDLTLDEEDMTMEELDQTAGTSQ--GGE----GSSQTYATWQHDRSQDELGLMAQDAQ 449
                :.|:.|..:|.:...|:.||..||..  .||    |.|.:..| :.|..:.:.|..|....
Human   339 YYGQQRVQILERNESEECTEDTDQAEGTESEPKGESFDSGVSSSIGT-EPDSVEQQFGPGAARDS 402

  Fly   450 QRDPQASKQ------DKGEQTE----GAQDEFELDDCLLESNDIVITQNKDGFVLHVKKLGNITA 504
            |.:|...:|      :.|.||.    ||......::..::|..|.::.:.|..||....:.....
Human   403 QAEPTQPEQAAEAPAEGGPQTNQLETGASSPERSNEVEMDSTVITVSNSSDKSVLQQPSVNTSIG 467

  Fly   505 AKLEENQAVAQQQG------QAAVTVT------GPAGQPTPTITELLNAAAASHSEPKPTLTTLT 557
            ..|...|...:|..      :..:|:|      |.||.   |....|.....:.|.|||.|.:|
Human   468 QPLPSTQLYLRQTETLTSNLRMPLTLTSNTQVIGTAGN---TYLPALFTTQPAGSGPKPFLFSL- 528

  Fly   558 STPIKLPSSECELINIKK--------IIPATTTIATHHPHTSSTIIHPHHIIQHVSQEPHH---- 610
              |..|...:.:.:.:.:        .:||...:|:...|::::        ....::|:.
Human   529 --PQPLAGQQTQFVTVSQPGLSTFTAQLPAPQPLASSAGHSTAS--------GQGEKKPYECTLC 583

  Fly   611 ------QEHHQQHQTIHIEEVPQTSQQHHQQQHHHQLQTVQPTHTQVQSII---TAHPGQTINLV 666
                  ::::.:|..:|..|.|            ||......:.:....:|   ..|.|......
Human   584 NKTFTAKQNYVKHMFVHTGEKP------------HQCSICWRSFSLKDYLIKHMVTHTGVRAYQC 636

  Fly   667 GLRNVQLADSKPIASRIRYSRGK------IIGPTVQNLQIVETHEPIQHQHHELSDGTKYEISEI 725
            .:.|.:......:...:|..||:      |......:..::|.|..:    |..|:||.
Human   637 SICNKRFTQKSSLNVHMRLHRGEKSYECYICKKKFSHKTLLERHVAL----HSASNGTP------ 691

  Fly   726 DLNNPNASAAIISDLVKYAEIDDIELPDGTKIGIGFAPSEITEHMQTSGGETHITTIEHEPQELQ 790
                                      |.||..|....|..:   :..:.|.|::.::  .|.:..
Human   692 --------------------------PAGTPPGARAGPPGV---VACTEGTTYVCSV--CPAKFD 725

  Fly   791 TVHQHEQTQQTH 802
            .:.|.....:.|
Human   726 QIEQFNDHMRMH 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lola	NP_788308.3	BTB	22..117	CDD:279045	34/97 (35%)
		BTB	33..117	CDD:197585	31/83 (37%)
		C2H2 Zn finger	905..925	CDD:275368
		C2H2 Zn finger	935..955	CDD:275368
ZBTB20	NP_001157814.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32
		BTB_POZ_ZBTB20_DPZF	79..195	CDD:349517	38/107 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	203..235		10/48 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	350..440		22/90 (24%)
		PHA03169	<352..>442	CDD:223003	22/90 (24%)
		Med15	<378..>571	CDD:312941	41/207 (20%)
		zf-C2H2	578..600	CDD:395048	1/21 (5%)
		C2H2 Zn finger	580..600	CDD:275368	1/19 (5%)
		SUF4-like	608..>657	CDD:411020	5/48 (10%)
		C2H2 Zn finger	608..629	CDD:411020	1/20 (5%)
		C2H2 Zn finger	608..628	CDD:275368	1/19 (5%)
		zf-C2H2	634..656	CDD:395048	2/21 (10%)
		C2H2 Zn finger	636..656	CDD:411020	2/19 (11%)
		C2H2 Zn finger	636..656	CDD:275368	2/19 (11%)
		zf-H2C2_2	648..673	CDD:404364	4/24 (17%)
		C2H2 Zn finger	664..684	CDD:275368	3/23 (13%)
		C2H2 Zn finger	717..737	CDD:275368	2/21 (10%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	124	1.000	Inparanoid score	I4726
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960