DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lola and pre-lola-G

DIOPT Version :9

Sequence 1:	NP_788308.3	Gene:	lola / 44548	FlyBaseID:	FBgn0283521	Length:	970	Species:	Drosophila melanogaster
Sequence 2:	NP_001260870.2	Gene:	pre-lola-G / 14462577	FlyBaseID:	FBgn0264817	Length:	436	Species:	Drosophila melanogaster

Alignment Length:	471	Identity:	128/471 - (27%)
Similarity:	163/471 - (34%)	Gaps:	173/471 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   503 TAAKLEENQAVAQQQGQAAVTVTGPAGQPTPTITELLNAAAASHSEPKPTLTTLTSTPIKLPSSE 567
            ||:|......|.:.|...|..|.|.|.          .|||:.|..||.||.|..|:.....:
  Fly   101 TASKNLNADEVMRVQNATATRVVGAAA----------GAAASFHPRPKYTLKTAASSTEHTTA-- 153

  Fly   568 CELINIKKIIPATTTIATHHPHTSSTIIHPHHIIQHVSQEPHHQEHHQQHQTIHIEEVPQTSQQH 632
                     ||.:..:|     .|:..:.|                  :.|...|.|....:..|
  Fly   154 ---------IPTSVLVA-----NSAAALTP------------------KPQAAVIAEALMRNGLH 186

  Fly   633 HQQQHHHQLQTVQPTHTQVQSIITAHPGQTINLVGLRNVQLADSKPIASRIRYSRGKIIGPT--V 695
            :.||   ||:..:....|     |.|          |.::..:...||       |..|.||  :
  Fly   187 NFQQ---QLRAQEILRQQ-----TPH----------RRIKEENDVEIA-------GGDITPTKIL 226

  Fly   696 QNLQIVETHEPIQHQHHELSDGTKYEISEIDLNNPNASAAIISDLVKYAEIDDIELPDGTKIGIG 760
            :||...:....::|...|...|...|..|..               :|...|||.|
  Fly   227 ENLLRKQQERDLRHSECENEPGYSTEDDEEG---------------RYHAFDDIHL--------- 267

  Fly   761 FAPSEITEHMQTSGGETHITTIEHEPQELQTVHQHEQTQQTHHIHAGQLQTHHIQTVVQSSSGQQ 825
                     |:.|||:                                         ..::||..
  Fly   268 ---------MEQSGGK-----------------------------------------FGNNSGMG 282

  Fly   826 QHDQQQHHQHHSIELQDDDGVETI--TPEELGMHDSSKSYTILTTRPMKEESEHDPSGMTYELSL 888
            ..:...|....|..|........:  |..:.|...|:.|.|             .|:|:..
  Fly   283 MFNANAHGGSASSILDAHQAFRNLEFTLSDYGGSSSNGSTT-------------SPNGIGL---- 330

  Fly   889 SDSSLGPCDDPESRYVCRHCGKKYRWKSTLRRHENVECGGKEPCHPCPYCSYKAKQRGNLGVHVR 953
                     |.|..|.|||||||||||||||||||||||||||.|.||||.||:|||||||||||
  Fly   331 ---------DGEPVYECRHCGKKYRWKSTLRRHENVECGGKEPSHQCPYCPYKSKQRGNLGVHVR 386

  Fly   954 KHHPEKPQLESKRGRK 969
            |||.:.|||.|||..|
  Fly   387 KHHTDLPQLPSKRRSK 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lola	NP_788308.3	BTB	22..117	CDD:279045
		BTB	33..117	CDD:197585
		C2H2 Zn finger	905..925	CDD:275368	19/19 (100%)
		C2H2 Zn finger	935..955	CDD:275368	17/19 (89%)
pre-lola-G	NP_001260870.2	C2H2 Zn finger	338..358	CDD:275368	19/19 (100%)
		zf-H2C2_5	366..389	CDD:290620	19/22 (86%)
		C2H2 Zn finger	368..388	CDD:275368	17/19 (89%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451050
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.930