DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hnf4 and RXRG

DIOPT Version :9

Sequence 1:NP_723413.1 Gene:Hnf4 / 44544 FlyBaseID:FBgn0004914 Length:732 Species:Drosophila melanogaster
Sequence 2:NP_008848.1 Gene:RXRG / 6258 HGNCID:10479 Length:463 Species:Homo sapiens


Alignment Length:489 Identity:162/489 - (33%)
Similarity:250/489 - (51%) Gaps:84/489 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    51 SSASRTASSDESESHIMHAD----------ALASAYPAASQPHSPIGLALSPNGGGLGLSNSSNQ 105
            |.::..::....:||..:.|          |:.:...|...|:..|..|:.|..|.|......|.
Human    28 SPSAALSTGKPMDSHPSYTDTPVSAPRTLSAVGTPLNALGSPYRVITSAMGPPSGALAAPPGINL 92

  Fly   106 SSENFALCNGNGNAGSAGGGSASSGSNNNNSMFS-----PNNNLSGSGSGTNSSQQQLQQQQQQQ 165
            .:                  ..||..|..||:.|     |...|.|.|:          ......
Human    93 VA------------------PPSSQLNVVNSVSSSEDIKPLPGLPGIGN----------MNYPST 129

  Fly   166 SP-----TVCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHQYTCRFARNCVVDKDKRNQCRYC 225
            ||     .:|||||||::|||||..||:||||||:|::||:..||||..::|::||.:||:|:||
Human   130 SPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKDCLIDKRQRNRCQYC 194

  Fly   226 RLRKCFKAGMKKEAVQNERDR--------ISCRRTSNDDPDPGNGLSVISLVKAE---NESRQSK 279
            |.:||...|||:||||.||.|        ..|..:.::|      :.|..:::||   ....:|.
Human   195 RYQKCLVMGMKREAVQEERQRSRERAESEAECATSGHED------MPVERILEAELAVEPKTESY 253

  Fly   280 AGAAMEPNINEDLSNKQFASINDVCESMKQQLLTLVEWAKQIPAFNELQLDDQVALLRAHAGEHL 344
            ....||.:.|:.::|        :|.:..:||.|||||||:||.|::|.|:|||.||||...|.|
Human   254 GDMNMENSTNDPVTN--------ICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELL 310

  Fly   345 LLGLSRRSMHLKDVLLLSNNCVITRHCPDPLVSPNLDISRIGARIIDELVTVMKDVGIDDTEFAC 409
            :...|.||:.::|.:||:....:.|..     :.:..:..|..|::.|||:.|||:.:|.:|..|
Human   311 IASFSHRSVSVQDGILLATGLHVHRSS-----AHSAGVGSIFDRVLTELVSKMKDMQMDKSELGC 370

  Fly   410 IKALVFFDPNAKGLNEPHRIKSLRHQILNNLEDYISDRQYESRGRFGEILLILPVLQSITWQMIE 474
            ::|:|.|:|:||||:.|..:::||.::...||.|...:..|..|||.::||.||.|:||..:.:|
Human   371 LRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSIGLKCLE 435

  Fly   475 QIQFAKIFGVAHIDSLLQEMLLGGELADNPLPLS 508
            .:.|.|:.|...||:.|.|||      :.||.::
Human   436 HLFFFKLIGDTPIDTFLMEML------ETPLQIT 463

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hnf4NP_723413.1 NR_DBD_HNF4A 170..245 CDD:143518 46/74 (62%)
NR_LBD_HNF4_like 264..494 CDD:132729 82/232 (35%)
RXRGNP_008848.1 Modulating. /evidence=ECO:0000250 1..138 25/137 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 18..53 4/24 (17%)
Nuc_recep-AF1 25..133 CDD:314658 25/132 (19%)
NR_DBD_RXR 137..213 CDD:143514 45/75 (60%)
Hinge 205..230 9/24 (38%)
NR_LBD_RXR_like 233..441 CDD:132741 78/226 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165144377
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D389616at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.850

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