Protein Alignment Hnf4 and RXRA

DIOPT Version :10

• Sequence 1: NP_723413.1
• Gene: Hnf4 / 44544
• FlyBaseID: FBgn0004914
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_002948.1
• Gene: RXRA / 6256
• HGNCID: 10477
• Length: 462
• Species: Homo sapiens
• Alignment Length: 445
• Identity: 160/445 - (35%)
• Similarity: 244/445 - (54%)
• Gaps: 45/445 - (10%)

  Fly    71 ALASAYPAASQPHSPIGLALSP-NGGGLGLSNSSNQSSENFALCNGNGNAG-SAGGGSASSGSN- 132
            :|.....:..|.||||....|| ||.|...|..|:....:..........| |.|....||..|
Human    36 SLGPGIGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNP 100

  Fly   133 -NNNSMFSPNNNLSG--------SGSGTNSSQQQLQQQQQQQSPTVCAICGDRATGKHYGASSCD 188
             :::....|...|:|        ||:..:.::.            :|||||||::|||||..||:
Human   101 VSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKH------------ICAICGDRSSGKHYGVYSCE 153

  Fly   189 GCKGFFRRSVRKNHQYTCRFARNCVVDKDKRNQCRYCRLRKCFKAGMKKEAVQNERDR------- 246
            ||||||:|:|||:..||||..::|::||.:||:|:|||.:||...|||:||||.||.|
Human   154 GCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNEN 218

  Fly   247 -ISCRRTSNDDPDPGNGLSVISLVKAENESRQSKAGAAMEPNINEDLSNKQFASINDVCESMKQQ 310
             :....::|:|......|.....|:.:.|: ..:|...:.|:...|       .:.::|::..:|
Human   219 EVESTSSANEDMPVERILEAELAVEPKTET-YVEANMGLNPSSPND-------PVTNICQAADKQ 275

  Fly   311 LLTLVEWAKQIPAFNELQLDDQVALLRAHAGEHLLLGLSRRSMHLKDVLLLSNNCVITRHCPDPL 375
            |.|||||||:||.|:||.|||||.||||...|.|:...|.||:.:||.:||:....:.|:.
Human   276 LFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNS---- 336

  Fly   376 VSPNLDISRIGARIIDELVTVMKDVGIDDTEFACIKALVFFDPNAKGLNEPHRIKSLRHQILNNL 440
             :.:..:..|..|::.|||:.|:|:.:|.||..|::|:|.|:|::|||:.|..:::||.::..:|
Human   337 -AHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASL 400

  Fly   441 EDYISDRQYESRGRFGEILLILPVLQSITWQMIEQIQFAKIFGVAHIDSLLQEML 495
            |.|...:..|..|||.::||.||.|:||..:.:|.:.|.|:.|...||:.|.|||
Human   401 EAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEML 455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	47/74 (64%)
		NR_LBD_HNF4_like	264..494	CDD:132729	81/229 (35%)
RXRA	NP_002948.1	Modulating. /evidence=ECO:0000250	1..134		24/109 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..107		19/70 (27%)
		Nuc_recep-AF1	17..127	CDD:463363	24/90 (27%)
		NR_DBD_RXR	133..209	CDD:143514	46/87 (53%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:12145331	160..165		2/4 (50%)
		Hinge	201..224		8/22 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	206..228		4/21 (19%)
		NR_LBD_RXR_like	229..440	CDD:132741	78/223 (35%)
		Required for nuclear export. /evidence=ECO:0000269|PubMed:15509776	348..368		9/19 (47%)