Protein Alignment Hnf4 and rxraa

DIOPT Version :10

• Sequence 1: NP_723413.1
• Gene: Hnf4 / 44544
• FlyBaseID: FBgn0004914
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: XP_005161240.1
• Gene: rxraa / 555578
• ZFINID: ZDB-GENE-070314-2
• Length: 500
• Species: Danio rerio
• Alignment Length: 482
• Identity: 179/482 - (37%)
• Similarity: 264/482 - (54%)
• Gaps: 59/482 - (12%)

  Fly    44 RRRRRRDSSASRTAS--SDESESHIMHADALA--SAYPAASQPHSPIGLALSP-NGGGLGLSNSS 103
            :||...|.:...|:|  |..:....||...|:  |..|:.|. ||||....|| ||.|...|..|
Zfish    41 QRRLSTDCTGQVTSSPLSSPTSHRGMHPSLLSPTSLGPSGSL-HSPISTLSSPMNGLGSPFSVIS 104

  Fly   104 NQSSENFALCNGNGNAGSAGGGSASSGSNNNNSMFSPNNNLSGSGS-----GTNSSQQQLQQQQQ 163
            :..        |..:..|.|.|...|.|...|   ||.|::|.|..     |.|.    :.:...
Zfish   105 SPM--------GPHSMASPGVGYGPSISPQLN---SPMNSVSSSEDIKPPLGLNG----VMKVPA 154

  Fly   164 QQSPT-------VCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHQYTCRFARNCVVDKDKRNQ 221
            |.|.|       :|||||||::|||||..||:||||||:|:|||:..||||..::||:||.:||:
Zfish   155 QPSGTPLSLTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCVIDKRQRNR 219

  Fly   222 CRYCRLRKCFKAGMKKE-----AVQNERDR--------ISCRRTSNDDPDPGNGLSVISLVKAEN 273
            |:|||.:||...|||:|     |||.||.|        :....::|:|      :.|..:::||
Zfish   220 CQYCRYQKCLAMGMKREVLLHTAVQEERQRAKERSENEVESTSSANED------MPVEKILEAE- 277

  Fly   274 ESRQSKAGAAMEPNINEDLSNKQFASINDVCESMKQQLLTLVEWAKQIPAFNELQLDDQVALLRA 338
            .:.:.|....:|.|:... ||.....:.::|::..:||.|||||||:||.|:||.|||||.||||
Zfish   278 LAVEPKTETYIETNVPMP-SNSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRA 341

  Fly   339 HAGEHLLLGLSRRSMHLKDVLLLSNNCVITRHCPDPLVSPNLDISRIGARIIDELVTVMKDVGID 403
            ...|.|:...|.||:.:||.:||:....:.|:.     :.:..:..|..|::.|||:.|:|:.:|
Zfish   342 GWNELLIASFSHRSIAVKDGILLATGLHVHRNS-----AHSAGVGAIFDRVLTELVSKMRDMQMD 401

  Fly   404 DTEFACIKALVFFDPNAKGLNEPHRIKSLRHQILNNLEDYISDRQYESRGRFGEILLILPVLQSI 468
            .||..|::|:|.|:|::|||:.|..:::||.::..:||.|...:..|..|||.::||.||.|:||
Zfish   402 KTELGCLRAIVLFNPDSKGLSNPGEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSI 466

  Fly   469 TWQMIEQIQFAKIFGVAHIDSLLQEML 495
            ..:.:|.:.|.|:.|...||:.|.|||
Zfish   467 GLKCLEHLFFFKLIGDTPIDTFLMEML 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	48/79 (61%)
		NR_LBD_HNF4_like	264..494	CDD:132729	84/229 (37%)
rxraa	XP_005161240.1	Nuc_recep-AF1	63..160	CDD:463363	33/112 (29%)
		NR_DBD_RXR	166..247	CDD:143514	47/80 (59%)
		NR_LBD_RXR_like	267..478	CDD:132741	80/223 (36%)