DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hnf4 and hnf4a

DIOPT Version :9

Sequence 1:	NP_723413.1	Gene:	Hnf4 / 44544	FlyBaseID:	FBgn0004914	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	XP_021325423.1	Gene:	hnf4a / 322358	ZFINID:	ZDB-GENE-030131-1077	Length:	470	Species:	Danio rerio

Alignment Length:	430	Identity:	243/430 - (56%)
Similarity:	306/430 - (71%)	Gaps:	40/430 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 NLSGSGSGTNSSQQQ---LQQQQQQQSPTVCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHQY 204
            |:......|:||.|:   :.......:.|:|||||||||||||||||||||||||||||||||.|
Zfish    32 NMQVLAMSTDSSPQESANMNAANHLGAGTLCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMY 96

  Fly   205 TCRFARNCVVDKDKRNQCRYCRLRKCFKAGMKKE-----AVQNERDRISCRRTSNDDPD-PGNGL 263
            :|||.|.|:||||||||||||||:|||:||||||     ||||||||||.||:|.:|.. |
Zfish    97 SCRFNRQCIVDKDKRNQCRYCRLKKCFRAGMKKEVISSSAVQNERDRISTRRSSYEDSSLP---- 157

  Fly   264 SVISLVKAENESRQ-SKAGAAMEPNINEDLSNKQFASINDVCESMKQQLLTLVEWAKQIPAFNEL 327
            |:.:|::|:..||| |..|    |.:|.|:..|:.|:|.|||||||||||.||||||.||||.:|
Zfish   158 SINALIQADVLSRQISSPG----PILNGDIRTKKVAAIMDVCESMKQQLLVLVEWAKYIPAFCDL 218

  Fly   328 QLDDQVALLRAHAGEHLLLGLSRRSMHLKDVLLLSNNCVITRHCPDPLVSPNLDISRIGARIIDE 392
            .|||||||||||||||||||.::|||..||:|||.|:.:|.|:||:      |::||:..||:||
Zfish   219 PLDDQVALLRAHAGEHLLLGAAKRSMMYKDILLLGNDHIIPRNCPE------LEVSRVAVRILDE 277

  Fly   393 LVTVMKDVGIDDTEFACIKALVFFDPNAKGLNEPHRIKSLRHQILNNLEDYISDRQYESRGRFGE 457
            ||...:|:.|||.|:||:||:|||||:||||::|.:||.:|:|:..:|||||:||||:|||||||
Zfish   278 LVLPFQDLQIDDNEYACLKAIVFFDPDAKGLSDPSKIKRMRYQVQVSLEDYINDRQYDSRGRFGE 342

  Fly   458 ILLILPVLQSITWQMIEQIQFAKIFGVAHIDSLLQEMLLGGELADNPLP-------LSPPNQSN- 514
            :||:||.||||||||||||||.|:||:|.||:|||||||||...:.|..       |...:.||
Zfish   343 LLLLLPTLQSITWQMIEQIQFVKLFGMAKIDNLLQEMLLGGSANEAPHAHHSLHPHLVQEHLSNN 407

  Fly   515 -----DYQSPTHTGNMEGGNQVNSSLDSLATSGGPGSHSL 549
                 :..:|.|.|.|   :...:.:.|..|:.|...:.:
Zfish   408 VIVTANMATPLHNGQM---STPETPIPSPPTASGSDHYKM 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	67/79 (85%)
Hnf4	NP_723413.1	NR_LBD_HNF4_like	264..494	CDD:132729	143/230 (62%)
hnf4a	XP_021325423.1	NR_DBD_HNF4A	62..142	CDD:143518	67/79 (85%)
hnf4a	XP_021325423.1	NR_LBD_HNF4_like	158..379	CDD:132729	143/230 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	259	1.000	Domainoid score	I1950
eggNOG	1	0.900	-	-		E1_KOG4215
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	458	1.000	Inparanoid score	I1549
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003424
OrthoInspector	1	1.000	-	-		otm25745
orthoMCL	1	0.900	-	-		OOG6_105157
Panther	1	1.100	-	-	LDO	PTHR24083
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2679
SonicParanoid	1	1.000	-	-		X1958
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.850