DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hnf4 and HNF4A

DIOPT Version :9

Sequence 1:	NP_723413.1	Gene:	Hnf4 / 44544	FlyBaseID:	FBgn0004914	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	XP_005260464.1	Gene:	HNF4A / 3172	HGNCID:	5024	Length:	513	Species:	Homo sapiens

Alignment Length:	491	Identity:	258/491 - (52%)
Similarity:	317/491 - (64%)	Gaps:	60/491 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 LCNGNGNAGSAGGG------------------SASSGSNNNNSMFSPNNNLSGSGSGTNSSQQQL 158
            |..|||..|....|                  |.|.|.::     ||..:.|.| .|||     |
Human    34 LTMGNGRWGQMCPGILLPLRLARLRHPLRHHWSISGGVDS-----SPQGDTSPS-EGTN-----L 87

  Fly   159 QQQQQQQSPTVCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHQYTCRFARNCVVDKDKRNQCR 223
            ..........:|||||||||||||||||||||||||||||||||.|:|||:|.||||||||||||
Human    88 NAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCR 152

  Fly   224 YCRLRKCFKAGMKKEAVQNERDRISCRRTSNDDPD-PGNGLSVISLVKAENESRQSKAGAAMEPN 287
            ||||:|||:||||||||||||||||.||:|.:|.. |    |:.:|::||..|||..:..:   .
Human   153 YCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLP----SINALLQAEVLSRQITSPVS---G 210

  Fly   288 INEDLSNKQFASINDVCESMKQQLLTLVEWAKQIPAFNELQLDDQVALLRAHAGEHLLLGLSRRS 352
            ||.|:..|:.|||.|||||||:|||.||||||.||||.||.|||||||||||||||||||.::||
Human   211 INGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRS 275

  Fly   353 MHLKDVLLLSNNCVITRHCPDPLVSPNLDISRIGARIIDELVTVMKDVGIDDTEFACIKALVFFD 417
            |..||||||.|:.::.||||:     ..::||:..||:||||...:::.|||.|:|.:||::|||
Human   276 MVFKDVLLLGNDYIVPRHCPE-----LAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFD 335

  Fly   418 PNAKGLNEPHRIKSLRHQILNNLEDYISDRQYESRGRFGEILLILPVLQSITWQMIEQIQFAKIF 482
            |:||||::|.:||.||.|:..:|||||:||||:|||||||:||:||.||||||||||||||.|:|
Human   336 PDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLF 400

  Fly   483 GVAHIDSLLQEMLLGGELADNPLPLSP--PNQSNDYQS---------PTHTGNME-------GGN 529
            |:|.||:|||||||||..:|.|....|  |:...::..         |||..|.:       .|.
Human   401 GMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEWPRPRGQ 465

  Fly   530 QVNSSLDSLATSGGPGSHSLDLEVQHIQALIEANSA 565
            .........:..||.||....|....:..:::..||
Human   466 AATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSA 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	68/74 (92%)
Hnf4	NP_723413.1	NR_LBD_HNF4_like	264..494	CDD:132729	141/229 (62%)
HNF4A	XP_005260464.1	NR_DBD_HNF4A	99..174	CDD:143518	68/74 (92%)
HNF4A	XP_005260464.1	NR_LBD_HNF4_like	190..412	CDD:132729	141/229 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	255	1.000	Domainoid score	I2052
eggNOG	1	0.900	-	-		E1_KOG4215
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	451	1.000	Inparanoid score	I1610
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003424
OrthoInspector	1	1.000	-	-		otm42307
orthoMCL	1	0.900	-	-		OOG6_105157
Panther	1	1.100	-	-	LDO	PTHR24083
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2679
SonicParanoid	1	1.000	-	-		X1958
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.850