DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hnf4 and Hnf4g

DIOPT Version :9

Sequence 1:	NP_723413.1	Gene:	Hnf4 / 44544	FlyBaseID:	FBgn0004914	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	XP_006530135.1	Gene:	Hnf4g / 30942	MGIID:	1353604	Length:	462	Species:	Mus musculus

Alignment Length:	387	Identity:	230/387 - (59%)
Similarity:	289/387 - (74%)	Gaps:	31/387 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 NNNNSMFSPNNNLSGSGSGTNSSQQQLQQQQQQQSPTVCAICGDRATGKHYGASSCDGCKGFFRR 196
            |.|:|......:::.:.||.|               .:|||||||||||||||||||||||||||
Mouse    43 NPNDSSAPETTSMNTTDSGVN---------------CLCAICGDRATGKHYGASSCDGCKGFFRR 92

  Fly   197 SVRKNHQYTCRFARNCVVDKDKRNQCRYCRLRKCFKAGMKKEAVQNERDRISCRRTSNDDPDPGN 261
            |:||:|.|:|||:|.||||||||||||||||||||:||||||||||||||||.||::.:    |:
Mouse    93 SIRKSHVYSCRFSRQCVVDKDKRNQCRYCRLRKCFRAGMKKEAVQNERDRISTRRSTYE----GS 153

  Fly   262 GL-SVISLVKAENESRQSKAGAAMEPNINEDLSNKQFASINDVCESMKQQLLTLVEWAKQIPAFN 325
            .: |:.:|.:||..|.|.   :...|:.:.|::.|:.|||:|||||||||||.||||||.||||.
Mouse   154 NIPSINTLAQAEVRSCQI---SVPSPSSSTDINIKKIASISDVCESMKQQLLVLVEWAKYIPAFC 215

  Fly   326 ELQLDDQVALLRAHAGEHLLLGLSRRSMHLKDVLLLSNNCVITRHCPDPLVSPNLDISRIGARII 390
            ||.|||||||||||||||||||.::|||..||:|||.|:.||.|:      |..:::||:..|::
Mouse   216 ELPLDDQVALLRAHAGEHLLLGATKRSMMYKDILLLGNHYVIHRN------SCEVEVSRVANRVL 274

  Fly   391 DELVTVMKDVGIDDTEFACIKALVFFDPNAKGLNEPHRIKSLRHQILNNLEDYISDRQYESRGRF 455
            ||||...:::.|||.|:||:||:|||||:||||::|.:||::|.|:..:|||||:||||:|||||
Mouse   275 DELVRPFQEIQIDDNEYACLKAIVFFDPDAKGLSDPVKIKNMRFQVQISLEDYINDRQYDSRGRF 339

  Fly   456 GEILLILPVLQSITWQMIEQIQFAKIFGVAHIDSLLQEMLLGGELADNPLPLSP--PNQSND 515
            ||:||:||.||||||||||||||.|:||:..||:|||||||||...|......|  |:.|.|
Mouse   340 GELLLLLPTLQSITWQMIEQIQFVKLFGMVKIDNLLQEMLLGGAANDGSHLHHPMHPHLSQD 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	67/74 (91%)
Hnf4	NP_723413.1	NR_LBD_HNF4_like	264..494	CDD:132729	138/229 (60%)
Hnf4g	XP_006530135.1	NR_DBD_HNF4A	66..141	CDD:143518	67/74 (91%)
Hnf4g	XP_006530135.1	NR_LBD_HNF4_like	157..378	CDD:132729	138/229 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	254	1.000	Domainoid score	I2052
eggNOG	1	0.900	-	-		E1_KOG4215
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	453	1.000	Inparanoid score	I1590
Isobase	1	0.950	-	0	Normalized mean entropy	S3544
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003424
OrthoInspector	1	1.000	-	-		otm44360
orthoMCL	1	0.900	-	-		OOG6_105157
Panther	1	1.100	-	-	LDO	PTHR24083
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2679
SonicParanoid	1	1.000	-	-		X1958
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.800