Protein Alignment Hnf4 and Thra

DIOPT Version :10

• Sequence 1: NP_723413.1
• Gene: Hnf4 / 44544
• FlyBaseID: FBgn0004914
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_001300912.1
• Gene: Thra / 21833
• MGIID: 98742
• Length: 492
• Species: Mus musculus
• Alignment Length: 501
• Identity: 126/501 - (25%)
• Similarity: 206/501 - (41%)
• Gaps: 97/501 - (19%)

  Fly   130 GSN-NNNSMFSPNNN---------LSGSGSGTNSSQQQLQQQQQQQSPTVCAICGDRATGKHYGA 184
            ||: ..||..||:..         |..|.||...|.....:|        |.:|||:|||.||..
Mouse    11 GSDPEENSARSPDGKRKRKNGQCPLKSSMSGYIPSYLDKDEQ--------CVVCGDKATGYHYRC 67

  Fly   185 SSCDGCKGFFRRSVRKN-H-QYTCRFARNCVVDKDKRNQCRYCRLRKCFKAGMKKEAVQNERDRI 247
            .:|:||||||||:::|| | .|:|::...||:||..||||:.||.:||...||..:.|.::..|:
Mouse    68 ITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRV 132

  Fly   248 SCR----------------RTSNDDPDPGNGLSVISLVKAENESRQSKAGAAMEPN---INEDLS 293
            :.|                |:....|:|......:..|..|.....:..|:..:..   :.:|:.
Mouse   133 AKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHVATEAHRSTNAQGSHWKQRRKFLPDDIG 197

  Fly   294 NKQFASIND-----------VCESMKQQLLTLVEWAKQIPAFNELQLDDQVALLRAHAGEHLLLG 347
            .....|:.|           ..:.:...:..:|::||::|.|:||..:||:.||:....|.:.|.
Mouse   198 QSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLR 262

  Fly   348 LSRRSMHLKDVLLLSNNCVITRHCPDPLVSPNLDISRIGARIIDELVTVMKDVGIDDTEFACIKA 412
            .:.|.....|.|.||....:.|   :.|.:..|.:.   :..|.||...:....:||||.|.::|
Mouse   263 AAVRYDPESDTLTLSGEMAVKR---EQLKNGGLGVV---SDAIFELGKSLSAFNLDDTEVALLQA 321

  Fly   413 LVFFDPNAKGLNEPHRIKSLRHQILNNLEDYISDRQYE-------------------------SR 452
            ::....:..||....:|:..:...|...|.|::.|::.                         :.
Mouse   322 VLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKEREVQSSILYKGAAAE 386

  Fly   453 GRFGEILLILPVLQSITWQMIEQIQFAKIFG--VAHIDSLLQEM-LLGGELADNPLPLSPPNQSN 514
            ||.|..|.:.|..|.:....:.|       |  |..::..|.|. .|.|.:..:..|.||..:..
Mouse   387 GRPGGSLGVHPEGQQLLGMHVVQ-------GPQVRQLEQQLGEAGSLRGPVLQHQSPKSPQQRLL 444

  Fly   515 D--YQSPTHTGNMEGGNQVNSSLDSLATSGGPGSHSLDLEVQHIQA 558
            :  ::|.........|...:|...||::|    |.:.|.||...||
Mouse   445 ELLHRSGILHSRAVCGEDDSSEASSLSSS----SDTEDTEVCEDQA 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	38/76 (50%)
		NR_LBD_HNF4_like	264..494	CDD:132729	53/270 (20%)
Thra	NP_001300912.1	Modulating	1..52		11/40 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..33		6/21 (29%)
		NR_DBD_TR	52..138	CDD:143519	41/93 (44%)
		NR_LBD_TR	162..370	CDD:132733	43/213 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	457..492		11/34 (32%)