DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hnf4 and nhr-5

DIOPT Version :9

Sequence 1:	NP_723413.1	Gene:	Hnf4 / 44544	FlyBaseID:	FBgn0004914	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_001263823.2	Gene:	nhr-5 / 191717	WormBaseID:	WBGene00003604	Length:	688	Species:	Caenorhabditis elegans

Alignment Length:	707	Identity:	155/707 - (21%)
Similarity:	259/707 - (36%)	Gaps:	216/707 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 SAGGGSA----SSGSNN----NNSMFSPNNNLSGSGSGTNSSQQQLQQQQQQQSPTVCAICGDRA 177
            |:||.|:    :|||:|    |:|.....::..||.|.||                :|.:||...
Worm     2 SSGGNSSNVNRNSGSSNVITLNDSDEETEDSNLGSSSSTN----------------LCKVCGAEK 50

  Fly   178 TGKHYGASSCDGCKGFFRRSVRKNHQYTCRFARNCVVDKDKRNQCRYCRLRKCFKAGMKKEAVQN 242
            ...||||.||.||||||||::.|..|..|.....|.|...::.|||.||..||.:.||....|:.
Worm    51 AALHYGALSCVGCKGFFRRALLKADQLECAANGECTVSVLQKTQCRSCRFNKCLREGMNPAYVRP 115

  Fly   243 ERDR-----------ISCRRTSNDDPDPGNG-------------------LSVISL----VKAEN 273
            .||.           .:|     |..|.|..                   ::::::    :|.:.
Worm   116 NRDAPPKPRKPTTTVATC-----DQTDRGRTTKSREEWMKKMTVEMRTILMTLLNIETKVMKGDT 175

  Fly   274 ESRQSK----AGAAMEPNINE---DLSNK---------QFASINDVCESMKQQLLTLVEWAKQI- 321
            :...||    .|.....:|.|   .|..|         :.|..:::|....::|:..::|.:.:
Worm   176 QQEASKLYPLKGIDKLSDIIETPIQLKGKRTEMRYEAYRMAGNDELCAIAYRRLIAAIDWVESLS 240

  Fly   322 PAFNELQLDDQVALLRAHAGEHLLLGLSRRSMHL---KDVLLLSNNCVITR----------HCPD 373
            |....|...|::||:::.....::.....|:...   ::||.|.|...:.|          |..:
Worm   241 PLLGHLTPQDKIALVKSSFAPLMVFNFCARTAEACQDENVLCLCNFAYVPRNISKMYEDTYHLGN 305

  Fly   374 PLVSPNLDISRIGARIIDELVTVMKDVGIDDTEFACIKALVFFDPNAKGLNEP--HRIKSLRHQI 436
            .||.          |.::|||.|.::.|:.:.|..|:.|::..:|.||.:::.  .:|..||::|
Worm   306 GLVE----------RALNELVAVYREYGMREEEIVCVNAMICLNPLAKDVSDSLFEKIVELRNRI 360

  Fly   437 LNNLEDYISDRQYESRGR--FGEILLILPVLQSITWQMIEQIQFAK-------------IFGVAH 486
            .:.|...:.:.:......  :|.|||.|..:..:...|.|.:|||:             :||...
Worm   361 ADCLFSIVKEVRLSPTPNVCYGHILLSLATVTELANAMSENLQFAQTFSNQGEIPLLTDLFGCFT 425

  Fly   487 IDSLLQEMLLGGELA-------------------------------------DNPLP-------L 507
            ::...:|:   .|||                                     |:..|       |
Worm   426 VEPFFKEV---DELAAMSLEKAKAEKKKEMSTQTDRLPPPRALLKRQATIDEDSEEPARQNFRLL 487

  Fly   508 SPPN------QSNDYQSPTHTGNMEGGNQVNSSLDSLATSGGPGSH--SLDLEVQHI-QALIEAN 563
            .|||      ..:|.::|:.|  ....:..||::::.|.     :|  ||:.:..:: .|:....
Worm   488 QPPNNFYITEMLDDLRAPSST--QSSSDDPNSAMNNHAE-----NHLISLNFDASNVSNAIASRP 545

  Fly   564 SADD---------------------SFRAYAASTAAAAAAAVSSSSSA-------PASVAP--AS 598
            |.:|                     |......||........||::|:       |....|  |.
Worm   546 SFEDLGTVPSGSTVTRRIGSNIQGPSHLPQCGSTVTQRPTVPSSTTSSTFYNFPPPPGYPPLNAG 610

  Fly   599 ISPPLNSPKSQHQHQQHATHQQQQESSYLDMPVKHYNG--SRSGPLPTQHSPQRMHP 653
            .:|.:|.|....|.|.....||....|.: |..::|..  |.|.|.|........||
Worm   611 YTPNVNYPNLYQQPQYFQNFQQNNYPSQV-MEQQNYGNVESTSYPFPRNDGFVYNHP 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	32/74 (43%)
Hnf4	NP_723413.1	NR_LBD_HNF4_like	264..494	CDD:132729	55/280 (20%)
nhr-5	NP_001263823.2	NR_DBD_HNF4A	43..118	CDD:143518	32/74 (43%)
nhr-5	NP_001263823.2	HOLI	225..394	CDD:214658	38/178 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910