DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hnf4 and nhr-206

DIOPT Version :9

Sequence 1:	NP_723413.1	Gene:	Hnf4 / 44544	FlyBaseID:	FBgn0004914	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_506033.1	Gene:	nhr-206 / 187660	WormBaseID:	WBGene00011097	Length:	410	Species:	Caenorhabditis elegans

Alignment Length:	377	Identity:	88/377 - (23%)
Similarity:	163/377 - (43%)	Gaps:	80/377 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 SGTNSSQQQLQQQQQQQ-SPTVCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHQYTCRFARNC 212
            |.:||.|.::..:..:. .|..|.:||:.|.|.||..::|:|||.||||:|....:..||..:||
Worm    21 STSNSQQSEITNETSRNVLPEKCEVCGNPAVGYHYDVATCNGCKAFFRRTVITGRRVICRRRKNC 85

  Fly   213 VVDKDKRNQ--CRYCRLRKCFKAGMKKEAVQNE--------RDRISCRRTSNDDPDPGNGLSVIS 267
            :|:.:.:|:  |..||..||.:.||...|::.|        :|.:..:|      :|.:.: ::|
Worm    86 LVEMEPKNRRICPGCRFSKCEEVGMNPRAIRAEISSGGKILKDELIAKR------EPRSKI-MLS 143

  Fly   268 LVKAENESRQSKAGAAMEPNINEDLSNK-------QFASINDVCESMKQQL-------------- 311
            ....|||..:..:...:..|..::|.|.       .:.:::::.: ||..|
Worm   144 PKSKENEVSRLISDLNLIENQIDELFNSSLPINYGDWRTLSEIIQ-MKPYLKVSKIPNLKLIRNQ 207

  Fly   312 -------------LTLVEWAKQIPAFNELQLDDQVALLRAHAGEHLL-----LGLSRRSM--HLK 356
                         |.:||:||.:..|.::..:..:.|::     |.|     |..||||:  :..
Worm   208 MNAELAGYAHNGSLAMVEYAKMLDFFPKISKETAIKLVK-----HGLFMCGSLSFSRRSIQKYNS 267

  Fly   357 DVLLLSNNCVITRHCPDPLVSPN---LDISRIGARIIDELVTVMKDVGIDDTEFACIKALVFFDP 418
            |:|..::..|..:    |..:.|   ||..||..:.:..::.|.    :|..|:..:||:...:|
Worm   268 DILRFTDGSVAGK----PKTNWNGVMLDHRRIAQKTLHSILRVK----LDYVEYLFLKAITMCNP 324

  Fly   419 NAKGL--NEPHRIKSLRHQILNNLEDYISDRQYESRG--RFGEILLILPVLQ 466
            .....  .:...|...|.....:|.:|...:..:..|  ||..||.|:.:::
Worm   325 AVSDFPAEDQKIIDKHRFNYAQSLLNYCLKQHGQIHGADRFASILSIMSIME 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	31/84 (37%)
Hnf4	NP_723413.1	NR_LBD_HNF4_like	264..494	CDD:132729	49/251 (20%)
nhr-206	NP_506033.1	ZnF_C4	42..112	CDD:197701	29/69 (42%)
		Glyco_hydro_30	<128..229	CDD:304972	17/108 (16%)
		HOLI	216..376	CDD:214658	39/172 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24083
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010