Protein Alignment Hnf4 and nhr-119

DIOPT Version :10

• Sequence 1: NP_723413.1
• Gene: Hnf4 / 44544
• FlyBaseID: FBgn0004914
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_494368.2
• Gene: nhr-119 / 187340
• WormBaseID: WBGene00003709
• Length: 708
• Species: Caenorhabditis elegans
• Alignment Length: 553
• Identity: 139/553 - (25%)
• Similarity: 234/553 - (42%)
• Gaps: 104/553 - (18%)

  Fly   128 SSGSNNNNSMFSPNNNLSGSGSGTNSSQQQLQQQQQQQSPTVCAICGDRATGKHYGASSCDGCKG 192
            :|...|..:..|..::||...|.:..|.             .|.:|||.....|||..:|.||||
 Worm     6 TSSLENMAASISRKSSLSQIASHSGGSD-------------TCKVCGDGNAKTHYGVVTCFGCKG 57

  Fly   193 FFRRSVRKNHQYTCRFARNCVVDKDKRNQCRYCRLRKCFKAGMKKEAVQNERDRIS------CRR 251
            ||||::::..:||||...:||||:.:||.||:||.:||.:.||..:||:.:||...      .||
 Worm    58 FFRRTLKRPSEYTCRHNGHCVVDRHERNSCRFCRFKKCIEVGMDPKAVRPDRDATGRHYQGRQRR 122

  Fly   252 TSNDDPDPGN------------------GLSVISLVKAENES----------------RQSKAGA 282
            :.....|.|.                  .|..|.|:....:.                ||.....
 Worm   123 SKLSAEDEGEVDAEWMRKLPVDMRTTLMQLLNIDLIVGGGDGHTEPSKIYPLPFATSIRQLLEDP 187

  Fly   283 AMEPNINEDLSNKQFASIND---VCESMKQQLLTLVEWAKQIPAFNEL---QLDDQVALLRAHAG 341
            .:......::..:.|..||.   .|.: .::|:.:::||..:  |:.:   .:||::|:::|..|
 Worm   188 TLLDGKRTEMRYETFREINPDELPCIA-HRRLIAMIDWADHL--FDMMDVNNMDDKIAIVKASYG 249

  Fly   342 EHLLLGL-SRRSMH-LKDVLLLSNNCVITRHCPDPLVSPNLDISRIGARIIDELVTVMKDVGIDD 404
            ..::..| :..|.| :.|::.||....|:|:.|:....|....:::..|.||||:..:|.:.:.:
 Worm   250 PLMIFSLCANTSRHKMSDIVCLSTFGYISRYAPNGWAEPYHFGNQLAERCIDELIDPLKKMNLKE 314

  Fly   405 TEFACIKALVFFDPNAKGLNE--PHRIKSLRHQILNNLEDYISDRQYE--SRGRFGEILLILPVL 465
            .|...|||::..:|..|.|.:  ...|..||.:|...|...:.:...:  :..|||.:||.:|.:
 Worm   315 EEITLIKAIIVLNPYLKTLTQDGSEAIMDLRDRIQETLYHVVRETHPKEVASSRFGNLLLFVPSV 379

  Fly   466 QSITWQMIEQIQFAKIFGVAHIDSLLQEMLLGG---ELADNPLPLSPPNQSNDYQSPT-----HT 522
            ..:...:.|.:.|...||..: |:|:.::|...   |...:|...|||..|....||:     |.
 Worm   380 MMLGRLVTENLSFVDSFGQMN-DALVHDLLQEAPKVEQNRSPTNTSPPTTSGMDTSPSPPIMNHH 443

  Fly   523 GNMEGGNQVNSSLDSLATSGGPGSHSLDLEVQHIQALIEANSADDSFRAYAASTAAAAAAAVS-- 585
            |       |:|..:.|    |...|  ||..:|.:..:..:|:..|..:...|...::....|
 Worm   444 G-------VSSQDEQL----GGAQH--DLGRRHSEPRMVHSSSSSSIESLNGSYQCSSDGGASYQ 495

  Fly   586 ----------SSSSAPASVAPASISPPLNSPKS 608
                      |.:|.||.|....:|  ||...|
 Worm   496 NQIGTLPYNLSCNSLPAQVNDFGVS--LNGASS 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	36/74 (49%)
		NR_LBD_HNF4_like	264..494	CDD:132729	57/257 (22%)
nhr-119	NP_494368.2	NR_DBD_HNF4A	35..110	CDD:143518	36/74 (49%)
		HOLI	214..380	CDD:214658	43/168 (26%)