DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hnf4 and nhr-180

DIOPT Version :9

Sequence 1:	NP_723413.1	Gene:	Hnf4 / 44544	FlyBaseID:	FBgn0004914	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_503286.1	Gene:	nhr-180 / 185170	WormBaseID:	WBGene00017961	Length:	399	Species:	Caenorhabditis elegans

Alignment Length:	373	Identity:	82/373 - (21%)
Similarity:	130/373 - (34%)	Gaps:	123/373 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 SPTVCAICG-DRATGKHYGASSCDGCKGFFRRSVRKNHQYTCRFAR-NC---VVDKDKRNQCRYC 225
            |...|.||. ::..|.|:|..||..|..||||:|..      |::| .|   ..|: |:..|:.|
Worm    12 SHKTCQICKVEKCHGNHFGVDSCRACAAFFRRTVHS------RWSREKCQGGTCDR-KKLLCKPC 69

  Fly   226 RLRKCFKAGMKKEAVQNERDRI-----------SCRRTSN-------DDPDP-----------GN 261
            ||::||:.||..:..|..||.|           |..|...       .|.:|           |.
Worm    70 RLQQCFEGGMVTDKFQYNRDLINPVYLKSSIPSSLERLLGKPHFVLISDKNPKKTTIDVHRLLGE 134

  Fly   262 GLSVISLVKAE----NESRQSKAGAAMEPNINEDLSNKQFASINDVCESMKQQLLTLVEW----- 317
            ...:::|..|.    ..:|..|...|:..|:.       |..::.:..:.|.::||..|:
Worm   135 ATKILNLGHAIPTYCGNNRLKKLSLAVHNNVT-------FEKLDVIKRATKSEILTNWEYYFKRV 192

  Fly   318 ---AKQIPAFNELQLDDQVALLRA--HAGEHLLLGLSRRSMHLKDVLLLSNNCVITRHCPDPLVS 377
               ......|.:|::..|:.||:.  |.... |..::..:.:.|.|
Worm   193 ATCLNHFDEFKKLEIPMQLKLLQTIWHVWGR-LEKITSSARYQKTV------------------- 237

  Fly   378 PNLDISRI---GARIIDELVTVMKDVGIDDTEFACIKALVFFDPNAKGLNEPHRIKSLRHQI--- 436
            .|..:|.:   ...|:|     :|||.||...|:..       ||       .::|:...|.
Worm   238 ENSKLSEVVFQSGWIVD-----VKDVDIDCNWFSNF-------PN-------EQVKNFMLQTSTD 283

  Fly   437 LNNLEDYISDR----------------QYESRGRFGEILLILPVLQSI 468
            |.|:..||.|.                ||......|||..:....|::
Worm   284 LFNVIQYIHDLDPTDVELTYMLAQLCFQYAGNRHRGEIQEVCEQFQNV 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	28/79 (35%)
Hnf4	NP_723413.1	NR_LBD_HNF4_like	264..494	CDD:132729	45/241 (19%)
nhr-180	NP_503286.1	ZnF_C4	15..82	CDD:197701	27/73 (37%)
nhr-180	NP_503286.1	Hormone_recep	167..373	CDD:278530	39/204 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910