DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hnf4 and nhr-264

DIOPT Version :9

Sequence 1:	NP_723413.1	Gene:	Hnf4 / 44544	FlyBaseID:	FBgn0004914	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_501622.3	Gene:	nhr-264 / 184443	WormBaseID:	WBGene00008778	Length:	358	Species:	Caenorhabditis elegans

Alignment Length:	322	Identity:	75/322 - (23%)
Similarity:	134/322 - (41%)	Gaps:	73/322 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 QQQQQQSPTVCAICGDRA-TGKHYGASSCDGCKGFFRRSVRKNHQYTCRFARNCVVDKDKRNQCR 223
            :.::|..|  |.:|.|.| |..|:|.:||..|..||||:..  :|:||....||.|...|:..||
Worm     2 EAERQYEP--CQVCQDSASTRHHFGITSCTACASFFRRTTM--NQFTCNLDNNCSVSYKKKWVCR 62

  Fly   224 YCRLRKCFKAGMKKEAVQNER-DRISCRRT------SNDDPDPGNGLSVIS--LVKAENESRQSK 279
            .||...|.:|||.|:.::... |....|:|      .|......:.|:.||  :...:|.:.:|.
Worm    63 ACRYNNCIRAGMSKDYIRRGNVDETKNRKTFRKRTIRNSIRRNKSSLNRISEPVKMDQNSTSRSS 127

  Fly   280 AGAAMEPNINED--------LSNKQFAS--INDVCESMKQQLLTLVEWAKQIPAFNELQLDDQVA 334
            ..::::.:.:..        |||.:...  :.:|..:|.|:...|.:.|....:.|||.
Worm   128 TSSSIKHSSDTSTEFSKILHLSNDELLQFYLKEVERTMVQKQRGLAKNALLAESMNELM------ 186

  Fly   335 LLRAHAGEHLLLGLSRRSMHLKDVLLLSNNCVITRHCPDPLVSPNLDISRIGARIIDELVTVMK- 398
            ::.|:..     |||..|            |:   |||.           :.:...:::.|::|
Worm   187 IISAYQN-----GLSMES------------CM---HCPG-----------VNSLEKEDVQTLLKY 220

  Fly   399 ----DVGIDDTEFACIKALVFFD--PNAKGLNE-PHRIK----SLRHQILNNLEDYISDRQY 449
                :|.:|......:..:..::  |..|.|:| ..::|    |...|:..||.::.:.:.|
Worm   221 FQFANVWMDSVRAYSMSNVDIYETTPKDKRLSEYIQQVKLTLGSSFSQLKLNLYEFAALKSY 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	30/76 (39%)
Hnf4	NP_723413.1	NR_LBD_HNF4_like	264..494	CDD:132729	38/210 (18%)
nhr-264	NP_501622.3	ZnF_C4	9..77	CDD:197701	30/71 (42%)
nhr-264	NP_501622.3	HOLI	189..343	CDD:214658	23/125 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910