DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hnf4 and nhr-173

DIOPT Version :9

Sequence 1:	NP_723413.1	Gene:	Hnf4 / 44544	FlyBaseID:	FBgn0004914	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_509119.4	Gene:	nhr-173 / 183862	WormBaseID:	WBGene00016975	Length:	508	Species:	Caenorhabditis elegans

Alignment Length:	509	Identity:	120/509 - (23%)
Similarity:	189/509 - (37%)	Gaps:	142/509 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 SNSSNQSSENFALCNGNGNAGS-----AGGGSASSGSNNNNSMFSPNNNLSGSGSGTNSSQQQ-- 157
            |.||::.|:...:.:...:..|     .|.|.......:...:..|..|||     .|..:|:
Worm    29 STSSSEGSDQQQIVSDFVDTASFMISWNGLGEFPDTEEDIKHVIQPTENLS-----LNIEEQKEI 88

  Fly   158 --LQQQQQQQSPTVCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHQYTCRFARNC--VVDKDK 218
              .....:...||:||:|||||||.||...||:|||.||||:|....:|.|.....|  |:.|:|
Worm    89 VAFHHLPRNVCPTICAVCGDRATGYHYEVPSCNGCKTFFRRTVLSQRKYECMRGGKCFNVLPKEK 153

  Fly   219 RNQCRYCRLRKCFKAGMKKEAVQNERDRISC----------RRTSNDDPDPGNGL-----SVISL 268
            |..||.||.:||.:.||...|:|. .|.:|.          |:.|.|:..|....     .|||:
Worm   154 RCSCRSCRFQKCVEVGMNPFAIQT-NDSLSSNAVVTKIVGKRKNSVDNSIPSTSKLTVLPEVISM 217

  Fly   269 ---------------VKAE-----------NESRQSKAGAAMEPNIN-----EDLSNKQFASIND 302
                           :|.:           :|.|..|.....:|.|:     ..:.|.....|:.
Worm   218 DNAIDRLIDGLMYLEIKVDDFRSCAYNPPTHEYRSLKYHLEQQPMISMADKLGPMPNWPLRQISH 282

  Fly   303 VCESMKQ--------------------QLLTLVEWAKQIPAFNELQLDDQVALLRAHAGEHLLLG 347
              |.||:                    .:||.||:||.....:::..:||:.||||     ::|.
Worm   283 --EEMKEYIESGNSEPMTPERKNWFVYDILTSVEYAKTFMFLHQIGKEDQILLLRA-----VVLK 340

  Fly   348 LSRRSMHLKDVLLLSNNCVITRHCPDPLV---------SPNLDISRIGAR------------IID 391
            |    |||........|.......||..|         :||..||::..:            .|.
Worm   341 L----MHLNQAFYSYENKYDMIFHPDGTVPPHSWKKNENPNDSISQMMTKQKMEEMKEEFTLSIR 401

  Fly   392 ELVTVMKDVGIDDTEFACIKALVFFDPNAKGLNEPHRIKSLRHQILNNLEDY--------ISDRQ 448
            :.||..    :|..|:...||:...:....||::     ..|..:....|.|        :::|.
Worm   402 QFVTYQ----LDKREYVLFKAITLCNATISGLSD-----HAREVVTREKEKYSKALMKYCLANRG 457

  Fly   449 YESRGRFGEILLILPVLQSITWQMIEQIQF-------AKIFGVAHIDSLLQEML 495
            .:....:..|:.:...|::   :...|..|       .|.|....:|.:::|:|
Worm   458 MKGPAHYAAIIALSNGLEN---RQKNQKDFHFIMKMMKKGFKFDLVDDVMEEVL 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	38/76 (50%)
Hnf4	NP_723413.1	NR_LBD_HNF4_like	264..494	CDD:132729	59/316 (19%)
nhr-173	NP_509119.4	NR_DBD_HNF4A	103..180	CDD:143518	38/77 (49%)
nhr-173	NP_509119.4	HOLI	307..476	CDD:214658	40/186 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24083
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010