DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hnf4 and nhr-163

DIOPT Version :9

Sequence 1:	NP_723413.1	Gene:	Hnf4 / 44544	FlyBaseID:	FBgn0004914	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_504766.1	Gene:	nhr-163 / 183182	WormBaseID:	WBGene00016368	Length:	358	Species:	Caenorhabditis elegans

Alignment Length:	392	Identity:	90/392 - (22%)
Similarity:	138/392 - (35%)	Gaps:	120/392 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 VCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHQYTCRFARNCVVDKD--KRNQCRYCRLRKCF 231
            :|.:||...:..|||.|.|..|..||||.|....|..     :|..|:.  ..:.|||||:.||.
Worm    13 LCLVCGADGSEPHYGGSCCRACAAFFRRYVHSTKQEI-----SCTCDQRLISSHPCRYCRMLKCM 72

  Fly   232 KAGMKKEAVQNERDRISCRRTSNDDPDPGNGLSVISLVKAENESRQSKAGAAMEPNINEDLSNKQ 296
            |.||.|..||..|::.....|.     ||..:.:            ||            |||
Worm    73 KIGMCKTQVQPPREKNKILNTF-----PGTTIMI------------SK------------LSN-- 106

  Fly   297 FASINDVCESMKQQLLTLVEWAKQIPAFNELQLDD-------QVAL-------LRAHAGEHLLLG 347
             :.|...|.:|.:   .:.:|........||:.||       |:..       |....||.:...
Worm   107 -SIIPKSCNNMYR---AVAKWVDFDQRRKELRGDDYFDYNLTQITKMVNFNTNLLWKLGESIFSD 167

  Fly   348 LSRRSMHLKDVLLLSNNCVITRHCPDPLVSPNLDIS---------------------------RI 385
            :||.|...|:.::  :|..|....   |:.|.:|.|                           :.
Worm   168 VSRLSKEDKNSMI--SNFYIKWQL---LMEPAIDYSAQYEQFKNYIGSNAYYQKCAYFYGSSMQK 227

  Fly   386 GARIID-ELVTVMK---------------DVGIDDTEFACIKALVFFDPNAKGLNEP--HRIKSL 432
            |.:|.| |.|.|..               .:..|..|:..|..|:.||.....:::.  :...::
Worm   228 GNKISDVETVKVFSPFWDYYYADFAEPVYKMNYDKVEYMAIFLLLLFDGAYSDISDDGVNLCTNI 292

  Fly   433 RHQILNNLEDYISDRQYESRGRFGEILLILPVL----QSITWQ--------MIEQIQFAKIF-GV 484
            |..||..|..|.|:... |..|..:|:..|.:|    :.:.:|        ||....:.:|: |:
Worm   293 RKVILRELNSYQSNNNC-SEVRLADIMETLRLLDKHEEKLHYQFWMCGSHKMIMDENYVQIYLGI 356

  Fly   485 AH 486
            .|
Worm   357 KH 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	30/76 (39%)
Hnf4	NP_723413.1	NR_LBD_HNF4_like	264..494	CDD:132729	56/295 (19%)
nhr-163	NP_504766.1	ZnF_C4	13..76	CDD:197701	25/67 (37%)
nhr-163	NP_504766.1	HOLI	165..327	CDD:214658	33/167 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910